DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10359 and angptl6

DIOPT Version :9

Sequence 1:	NP_001137882.1	Gene:	CG10359 / 38434	FlyBaseID:	FBgn0035452	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_001014821.1	Gene:	angptl6 / 561927	ZFINID:	ZDB-GENE-030131-9735	Length:	489	Species:	Danio rerio

Alignment Length:	534	Identity:	151/534 - (28%)
Similarity:	225/534 - (42%)	Gaps:	110/534 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PQLAAIATVMVLAAIC-------GFGTGSVLEVPGVTQAPPLPPRNLRNNQTR-SRIPNNFRSIA 59
            |...|:..::..|.:|       ..|:||              .:....||.| ||.....:|
Zfish     4 PASRALLFLLFCAGLCCVDGRKESVGSGS--------------SKGDDANQKRPSRASETKQS-- 52

  Fly    60 TPPIAPRCDYKELMTNLHDRVGILVTLDEDQR-HRLEV------IDKKLDQLVESSSARM--ESM 115
                  ||.|..::.. ....|.|..:.|..| :|.||      ::::.||| :....|:  |..
Zfish    53 ------RCSYTFIVPQ-QKLTGALCLITESARVNRSEVASLRALLERQQDQL-DQMRGRLEEEGT 109

  Fly   116 KAQQLDFLHR--LDSFEHIQRLSRNTLDELKGETDQVFGPRNVRELKHKLRNRKKMKDISRTVRD 178
            .|.::..|.|  ::....|.:|....|.|:..:.:||...|.:..|  .|....::..:|...||
Zfish   110 LASEMRILRRESVNMNARIAQLYAQLLSEIIQKKEQVEEQRRLEGL--LLNATSQLHQVSSNYRD 172

  Fly   179 VSQEQYPS--------SGIGTFNESNLNLSSRLDAL--ATLLASTALSVR-SVQVEVANLSR--- 229
            : :::|.:        |.|.|..|....|.:....|  ||.|.:...||. ::..|..::.|
Zfish   173 L-EKKYDTLASLVNNQSKIITLLEKQCQLKTSTKELQEATSLPAQQSSVLVNINTEPKDVQRDQS 236

  Fly   230 -----AIRRQSRLIQGKGLRSTPGQQPIFYGPSGLN-GPTATRQLPSSCSYSFLSNHGILK---- 284
                 |..||..|.........|.:.|....||..: ||.      ..|       |.:|:
Zfish   237 APFHQAQARQELLETFDDSPGPPTETPFISFPSTKSPGPW------HDC-------HNVLESGEK 288

  Fly   285 ----VQLTPESESFYVS--CDED-----WTVILSRTSDDVNFERGWLDYRDGFGNLAGDFFIGLN 338
                ..|.|.:.:..:.  ||:.     ||||..|....|||.|.|..|:.|||||.|::::||.
Zfish   289 TSGIYLLRPRNTNRLLQAWCDQSRAQGGWTVIQRRQDGSVNFFRTWDQYKQGFGNLDGEYWLGLE 353

  Fly   339 KLHALTSSALHELRIVMEDFSGNVAYAGYSLFAIGSEKELYPLVLLGKFQDNLTPSAGDSLSYHA 403
            .|:.|||.|.::||:.|||:.|...||.|..|.:..|.:.|.| .||.:|.    :||||||:|.
Zfish   354 HLYWLTSQATYKLRVAMEDWQGRQVYAEYDSFRVEPESDWYRL-RLGSYQG----TAGDSLSWHN 413

  Fly   404 GAKFSTVDQDNDNCLECNCALRHKGAGWFNNCAKSNL------FGEYTTQNQPGETGIWWDTF-S 461
            ...|:|:|:|.| ....|||...||..|::.||.|||      .|.|.::.|   .|::|..| .
Zfish   414 NKAFTTLDRDKD-AYTGNCAHYQKGGWWYHMCAHSNLNGVWYRGGHYRSRYQ---DGVYWAEFHG 474

  Fly   462 GQNSLKRVRWMIRP 475
            |..|||:|..||:|
Zfish   475 GSYSLKKVAMMIKP 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10359	NP_001137882.1	FReD	267..476	CDD:238040	84/231 (36%)
angptl6	NP_001014821.1	DUF1640	<46..150	CDD:285090	25/113 (22%)
		DUF4349	<126..230	CDD:305044	25/106 (24%)
		FReD	274..488	CDD:238040	85/235 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000029
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X25
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810