DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10359 and tnr

DIOPT Version :9

Sequence 1:	NP_001137882.1	Gene:	CG10359 / 38434	FlyBaseID:	FBgn0035452	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_919364.1	Gene:	tnr / 369191	ZFINID:	ZDB-GENE-030804-1	Length:	1350	Species:	Danio rerio

Alignment Length:	290	Identity:	95/290 - (32%)
Similarity:	141/290 - (48%)	Gaps:	42/290 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   215 LSVRSVQVEVANLSRAIRRQSRLIQGKGLRSTPGQQPIFYGPSGLNG----PTATRQLPSSCSYS 275
            |......:.:..|:.......||...:||.::     :....|...|    ||     |.:|:..
Zfish  1080 LDAEDTWIRLEGLAETTEYTVRLQVARGLETS-----VIVSTSFTTGNRLFPT-----PQNCAQH 1134

  Fly   276 FLSNH---GILKVQLTPE-SESFYVSCD-----EDWTVILSRTSDDVNFERGWLDYRDGFGNLAG 331
            .|:..   ||..:.:..: |:...|.||     ..|.|...|.:...:|.|.|.||:.|||:|..
Zfish  1135 LLNGETLGGIYTIYVNRDLSQGVQVYCDMTTDGGGWIVFQRRQNGLTDFSRKWTDYKIGFGSLED 1199

  Fly   332 DFFIGLNKLHALTSSALHELRIVMEDFSGNVAYAGYSLFAIGSEKELYPLVLLGKFQDNLTPSAG 396
            :|::||:.:|.:.:...:||||.|:|...:| ||.|..|:||..|.||.| .:|::    :.:||
Zfish  1200 EFWLGLDNIHKIAAQGRYELRIDMKDGQESV-YANYDRFSIGDSKSLYKL-RIGEY----SGTAG 1258

  Fly   397 DSLSYHAGAKFSTVDQDNDNCLECNCALRHKGAGWFNNCAKSNLFGEYTTQNQPGET----GIWW 457
            ||||||....|||.|:|||..: .||||.:|||.|:.||.::||.|:|      ||:    ||.|
Zfish  1259 DSLSYHQSRPFSTKDKDNDIAV-TNCALSYKGAWWYKNCHRANLNGKY------GESRHSQGINW 1316

  Fly   458 DTFSGQN-SLKRVRWMIRPIS-EGIDDARR 485
            ..:.|.. |:..|...:||.: ..|...||
Zfish  1317 YHWKGHEFSIPFVEMKMRPFNYRSISGKRR 1346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10359	NP_001137882.1	FReD	267..476	CDD:238040	81/222 (36%)
tnr	NP_919364.1	EGF_2	199..225	CDD:285248
		EB	234..283	CDD:279949
		EGF_2	294..318	CDD:285248
		fn3	323..401	CDD:278470
		fn3	411..490	CDD:278470
		fn3	500..579	CDD:278470
		FN3	590..674	CDD:238020
		fn3	682..754	CDD:278470
		fn3	771..849	CDD:278470
		FN3	859..935	CDD:214495
		fn3	949..1019	CDD:278470
		fn3	1035..1103	CDD:278470	3/22 (14%)
		FReD	1126..1336	CDD:238040	83/227 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100073
Panther	1	1.100	-	-	O	PTHR19143
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.810