DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG10359 and TNC

DIOPT Version :9

Sequence 1:NP_001137882.1 Gene:CG10359 / 38434 FlyBaseID:FBgn0035452 Length:485 Species:Drosophila melanogaster
Sequence 2:XP_016870167.1 Gene:TNC / 3371 HGNCID:5318 Length:2384 Species:Homo sapiens


Alignment Length:365 Identity:106/365 - (29%)
Similarity:164/365 - (44%) Gaps:68/365 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   167 KKMKDISRTVRDVSQEQYPSSGIGTFNESNLNL--------SSRLDALAT--LLASTALSVRSVQ 221
            :|:.:|:|||...:.| |..:.:....|..|.:        ||.:.|..|  |.:...|:...||
Human  2019 EKVPEITRTVSGNTVE-YALTDLEPATEYTLRIFAEKGPQKSSTITAKFTTDLDSPRDLTATEVQ 2082

  Fly   222 VEVANLSRAIRRQSRLIQGKGL--RSTPGQ-QPIFYGP--------------------SGLNGPT 263
            .|.|.|:....|.|  :.|..|  .|..|. :.:..||                    ..||||.
Human  2083 SETALLTWRPPRAS--VTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPL 2145

  Fly   264 ATRQL-------------PSSCSYSFL---SNHGILKVQLT-PESESFYVSCD-----EDWTVIL 306
            .:..:             |..||.:.|   :..|:..:.|. .::|:..|.||     ..|.|.|
Human  2146 RSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFL 2210

  Fly   307 SRTSDDVNFERGWLDYRDGFGNLAGDFFIGLNKLHALTSSALHELRIVMEDFSGNVAYAGYSLFA 371
            .|.:...||.:.|..|..|||:...:|::||:.|:.:|:...:|||:.:.| .|..|:|.|..|:
Human  2211 RRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRD-HGETAFAVYDKFS 2274

  Fly   372 IGSEKELYPLVLLGKFQDNLTPSAGDSLSYHAGAKFSTVDQDNDNCLECNCALRHKGAGWFNNCA 436
            :|..|..|.|.:.|     .:.:||||::||.|..|||.|:|.|:.: .||||.:|||.|:.||.
Human  2275 VGDAKTRYKLKVEG-----YSGTAGDSMAYHNGRSFSTFDKDTDSAI-TNCALSYKGAFWYRNCH 2333

  Fly   437 KSNLFGEYTTQNQPGETGIWWDTFSG-QNSLKRVRWMIRP 475
            :.||.|.|...|.  ..|:.|..:.| ::|::.....:||
Human  2334 RVNLMGRYGDNNH--SQGVNWFHWKGHEHSIQFAEMKLRP 2371

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10359NP_001137882.1 FReD 267..476 CDD:238040 74/232 (32%)
TNCXP_016870167.1 EGF_2 377..403 CDD:285248
EGF_2 408..434 CDD:285248
EGF_2 468..496 CDD:285248
EGF_2 504..527 CDD:285248
EGF_2 533..558 CDD:285248
fn3 624..695 CDD:306538
fn3 713..793 CDD:306538
fn3 804..884 CDD:306538
fn3 894..976 CDD:306538
fn3 986..1064 CDD:306538
fn3 1075..1154 CDD:306538
fn3 1169..1241 CDD:306538
fn3 1260..1327 CDD:306538
fn3 1348..1427 CDD:306538
fn3 1439..1508 CDD:306538
fn3 1533..1605 CDD:306538
fn3 1619..1691 CDD:306538
fn3 1716..1788 CDD:306538
fn3 1804..1883 CDD:306538
fn3 1894..1973 CDD:306538
fn3 1985..2055 CDD:306538 9/36 (25%)
fn3 2071..2143 CDD:306538 15/73 (21%)
Fibrinogen_C 2163..2372 CDD:278572 74/218 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2579
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100073
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.710

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