DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10359 and Tnn

DIOPT Version :9

Sequence 1:	NP_001137882.1	Gene:	CG10359 / 38434	FlyBaseID:	FBgn0035452	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_001100659.2	Gene:	Tnn / 304913	RGDID:	1306002	Length:	1562	Species:	Rattus norvegicus

Alignment Length:	490	Identity:	127/490 - (25%)
Similarity:	198/490 - (40%)	Gaps:	125/490 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 TQAPPL--PPRNLRNNQTRSRIPNNFRSIATPPIAPRCD------------YKELMTNLHDRVGI 82
            |:||..  .|:||..|    |:..|..:|:..|:....|            .||:..:......|
  Rat  1141 TKAPTEIDSPKNLVTN----RVTENTATISWDPVRATIDRYMVRYTSADGETKEVPVSKDQSSTI 1201

  Fly    83 LVTLDEDQRHRLEVIDKKLDQLVESSSARMESMKAQQLDFLHRLDSFEHIQRLSRNTLDELKGET 147
            |..|.....:.:.|..:|        .|| ||.||                        :.|..|
  Rat  1202 LTGLKPGMEYTIHVWAQK--------GAR-ESKKA------------------------DTKALT 1233

  Fly   148 DQVFGPRNVRE--LKHKLRNRKKMKDISRTVRDVSQEQYPSSGIGTFNESNLNLSSRLDALAT-- 208
             ::..|:|.|.  :.|                        |||:.|:    :..|:::|....
  Rat  1234 -EIDPPKNFRPFGVTH------------------------SSGVLTW----MPPSAQIDGYILTY 1269

  Fly   209 -----LLASTALSVRSVQVEVANLSRAIRRQSRLIQGKGLRSTPGQQPIFYGPSGLNGPTATRQL 268
                 :|....|.....:.|:.:|.:.:.....|:..||.:.:....      :.|:...|....
  Rat  1270 QLPNGILKEVELQRGQQRFELQDLEQGVTYPVSLVAFKGNQRSRSVS------TTLSTVDARFPH 1328

  Fly   269 PSSCSY----SFLSNHGILKVQLTPE-SESFYVSCDED-----WTVILSRTSDDVNFERGWLDYR 323
            ||.||.    :..:..|:..:.|..: |....|.||.|     |.|...|.:..::|.:.|..|.
  Rat  1329 PSDCSQVQQNTNAAASGLYTIYLNGDASRPMQVYCDMDTDGGGWIVFQRRNTGQLDFFKRWRSYV 1393

  Fly   324 DGFGNLAGDFFIGLNKLHALT--SSALHELRIVMEDFSGNVAYAGYSLFAIGSEKELYPLVLLGK 386
            :|||:...:|::||:|||.||  ::..:|:|..::. :...|||.|..|.:.|.||.|.| .:||
  Rat  1394 EGFGDPMKEFWLGLDKLHNLTTGTTTRYEVRADLQT-ANESAYAVYDFFQVASSKERYKL-SVGK 1456

  Fly   387 FQDNLTPSAGDSLSYHAGAKFSTVDQDNDNCLECNCALRHKGAGWFNNCAKSNLFGEYTTQNQPG 451
            ::.    :|||:|:||.|.||:|.|:|||..|. ||||.|.|..|:.||..:|..|:|      |
  Rat  1457 YRG----TAGDALTYHNGWKFTTFDRDNDIALS-NCALTHHGGWWYKNCHLANPNGKY------G 1510

  Fly   452 ET----GIWWDTFSGQN-SLKRVRWMIRPISEGID 481
            ||    |:.|:.:.|.. |:..|...|||.....|
  Rat  1511 ETKHSEGVNWEPWKGHEFSIPYVELKIRPFGYSRD 1545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10359	NP_001137882.1	FReD	267..476	CDD:238040	79/225 (35%)
Tnn	NP_001100659.2	EGF_2	<142..166	CDD:285248
		EGF_2	169..197	CDD:285248
		EB	181..233	CDD:279949
		EGF_2	233..259	CDD:285248
		fn3	264..332	CDD:278470
		fn3	359..434	CDD:278470
		fn3	444..521	CDD:278470
		FN3	532..608	CDD:214495
		FN3	620..696	CDD:214495
		fn3	708..785	CDD:278470
		fn3	796..875	CDD:278470
		fn3	884..961	CDD:278470
		fn3	972..1049	CDD:278470
		FN3	1060..1136	CDD:214495
		FN3	1148..1224	CDD:214495	18/88 (20%)
		fn3	1236..1313	CDD:278470	17/104 (16%)
		FReD	1327..1540	CDD:238040	79/225 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100073
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.710