DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10359 and Angpt4

DIOPT Version :9

Sequence 1:	NP_001137882.1	Gene:	CG10359 / 38434	FlyBaseID:	FBgn0035452	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_001099996.1	Gene:	Angpt4 / 296269	RGDID:	1307539	Length:	508	Species:	Rattus norvegicus

Alignment Length:	541	Identity:	126/541 - (23%)
Similarity:	202/541 - (37%)	Gaps:	170/541 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 VLEVPGVTQAPPLPPRNLRNNQTRSRIPNNFRSIATPPIAPRCDYKELMTNLHD----------- 78
            ||..|.:.|..|:.|..|..:.:..|.....|...|...|.|....:.::.|..
  Rat    47 VLPEPDICQLAPVAPEGLGGSNSLQRDLPAARHHLTDWRAQRAQRAQRVSQLEKILENNTQWLLK 111

  Fly    79 -RVGILVTLDED-----------------------------QRHRLEVIDKKL--------DQLV 105
             ...|.:.|..|                             |.|:|..::.::        .|::
  Rat   112 LEQSIQMNLRSDLAQAQQHTIQNQTTTMLALGANLMNQTMAQTHKLTAVEAQVLNHTSRVKTQML 176

  Fly   106 ESSSA-----RMESMKAQQLDFLH--------RLDSFEHIQRLSRNTLDELKGETDQVFGPRN-- 155
            |||.:     |...|::::|..|.        ||.:.|...:...|:|.:.:.:...:.|.:.
  Rat   177 ESSLSTNKLERQMLMQSRELQRLQGRNRALETRLQALEAQHQAQLNSLQDKREQLQSLLGHQTGA 241

  Fly   156 VRELKHKLR------------NRKKMKDISRTVRDVSQEQYPSSGIGTFNESNLNLSSRLDALAT 208
            :..|||.||            .::.|:.:.|.||.|:|:|:|.|                  |.|
  Rat   242 LANLKHSLRALSSNSSSLQQQQQQLMELVQRLVRIVAQDQHPVS------------------LKT 288

  Fly   209 LLASTALSVRSVQVEVANLSRAIRRQSRLIQGKGLRSTPGQQPIFYGPSGLNGPTATRQLPSSCS 273
                               .:.:.|....|:..|..::        |...::|...|:.|.
  Rat   289 -------------------PKPLFRDCAEIKRSGANTS--------GVYTIHGANMTKPLK---- 322

  Fly   274 YSFLSNHGILKVQLTPESESFYVSCDED-----WTVILSRTSDDVNFERGWLDYRDGFGNLAGDF 333
                                  |.||.:     ||:|..|....:||:|.|.:|::||||:|.:.
  Rat   323 ----------------------VFCDMETDGGGWTLIQRREDGSLNFQRTWEEYKEGFGNVAREH 365

  Fly   334 FIGLNKLHALTSSALHELRIVMEDFSGNVAYAGYSLFAIGSEKELYPL-----VLLGKFQDNLTP 393
            ::|...:|:|||...:.||:.:.|:.|:.....|..|.:|||::.|.|     .:..:.:::|.|
  Rat   366 WLGNEAVHSLTSRTAYLLRVELHDWEGHQTSIQYENFQLGSERQRYSLSVNDSSISARLKNSLAP 430

  Fly   394 SAGDSLSYHAGAKFSTVDQDNDNCLECNCALRHKGAGWFNNCAKSNLFGEY--TTQNQPGETGIW 456
            .         |.||||.|.|||||: |.||....|..||:.|..|||.|.|  ..|:.....||.
  Rat   431 Q---------GTKFSTKDMDNDNCM-CKCAQMLSGGWWFDACGLSNLNGIYYPVHQHLHKINGIR 485

  Fly   457 WDTFSGQN-SLKRVRWMIRPI 476
            |..|.|.: ||...|.|:||:
  Rat   486 WHYFRGPSYSLHGTRMMLRPM 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10359	NP_001137882.1	FReD	267..476	CDD:238040	70/221 (32%)
Angpt4	NP_001099996.1	FReD	291..506	CDD:238040	76/258 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X25
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900