DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10359 and ANGPTL2

DIOPT Version :9

Sequence 1:	NP_001137882.1	Gene:	CG10359 / 38434	FlyBaseID:	FBgn0035452	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_036230.1	Gene:	ANGPTL2 / 23452	HGNCID:	490	Length:	493	Species:	Homo sapiens

Alignment Length:	435	Identity:	118/435 - (27%)
Similarity:	187/435 - (42%)	Gaps:	95/435 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 QRHRLEVIDKKLD---------QLVESSSARMESMKAQ-QLDFLHRL----DSFEHIQRLSRNTL 140
            |:.::|.:.:.::         :|:...|..|.|...| .:..||.:    |:...:.:|....|
Human    99 QKRQIETLQQLVEVDGGIVSEVKLLRKESRNMNSRVTQLYMQLLHEIIRKRDNALELSQLENRIL 163

  Fly   141 DELKGETDQVFGPRNVRELKHKLRNRKKMKDISRTVRDVSQEQYPSSGIGTFNESNLNLSSRLDA 205
            ::   ..|.:......::|:||.::                       :.|...:...:.::|:.
Human   164 NQ---TADMLQLASKYKDLEHKYQH-----------------------LATLAHNQSEIIAQLEE 202

  Fly   206 LATLLAST--------ALSVRSVQVEVANLSRAIRRQS--RLIQGKGLRSTPGQQPIFYGPSGLN 260
            ....:.|.        |...|..|....|  |.|.:.|  .:...:.|:..|...|..
Human   203 HCQRVPSARPVPQPPPAAPPRVYQPPTYN--RIINQISTNEIQSDQNLKVLPPPLPTM------- 258

  Fly   261 GPTATRQLPSS----------CSYSFLSNHGILKVQLT-PESES--FYVSCDE-----DWTVILS 307
             ||.| .||||          |..:....|....:.|. ||:.:  ..|.||:     .||||..
Human   259 -PTLT-SLPSSTDKPSGPWRDCLQALEDGHDTSSIYLVKPENTNRLMQVWCDQRHDPGGWTVIQR 321

  Fly   308 RTSDDVNFERGWLDYRDGFGNLAGDFFIGLNKLHALTSSALHELRIVMEDFSGNVAYAGYSLFAI 372
            |....|||.|.|..|:.||||:.|::::||..::.||:...::|.:.|||:||...:|.|:.|.:
Human   322 RLDGSVNFFRNWETYKQGFGNIDGEYWLGLENIYWLTNQGNYKLLVTMEDWSGRKVFAEYASFRL 386

  Fly   373 GSEKELYPLVLLGKFQDNLTPSAGDSLSYHAGAKFSTVDQDNDNCLECNCALRHKGAGWFNNCAK 437
            ..|.|.|.| .||::..|    ||||.::|.|.:|:|:|:|:| ....|||...||..|:|.||.
Human   387 EPESEYYKL-RLGRYHGN----AGDSFTWHNGKQFTTLDRDHD-VYTGNCAHYQKGGWWYNACAH 445

  Fly   438 SNL------FGEYTTQNQPGETGIWWDTF-SGQNSLKRVRWMIRP 475
            |||      .|.|.::.|   .|::|..| .|..|||:|..||||
Human   446 SNLNGVWYRGGHYRSRYQ---DGVYWAEFRGGSYSLKKVVMMIRP 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10359	NP_001137882.1	FReD	267..476	CDD:238040	86/234 (37%)
ANGPTL2	NP_036230.1	FReD	273..487	CDD:238040	80/222 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X25
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810