DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10359 and Tnc

DIOPT Version :9

Sequence 1:	NP_001137882.1	Gene:	CG10359 / 38434	FlyBaseID:	FBgn0035452	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_001356140.1	Gene:	Tnc / 21923	MGIID:	101922	Length:	2110	Species:	Mus musculus

Alignment Length:	296	Identity:	93/296 - (31%)
Similarity:	142/296 - (47%)	Gaps:	43/296 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 GTFNESNLNLSSRLDALATLLASTALSVRSVQVEVANLSRAIRRQSRLIQGKGLRSTPGQQPIFY 254
            ||..|..:...:...:||.|..||..|.|     :..||.::|  |:|||            ..:
Mouse  1835 GTVKEVIVGPDTTSYSLADLSPSTHYSAR-----IQALSGSLR--SKLIQ------------TIF 1880

  Fly   255 GPSGLNGPTATRQLPSSCSYSFL---SNHGILKVQLT-PESESFYVSCD-----EDWTVILSRTS 310
            ...||..|     .|..||.:.|   :..|:..:.:. .::::..|.||     ..|.|.|.|.:
Mouse  1881 TTIGLLYP-----FPRDCSQAMLNGDTTSGLYTIYINGDKTQALEVYCDMTSDGGGWIVFLRRKN 1940

  Fly   311 DDVNFERGWLDYRDGFGNLAGDFFIGLNKLHALTSSALHELRIVMEDFSGNVAYAGYSLFAIGSE 375
            ...:|.|.|..|..|||:...:|::||:.|..:|:...:|||:.::| .|..|||.|..|::|..
Mouse  1941 GREDFYRNWKAYAAGFGDRREEFWLGLDNLSKITAQGQYELRVDLQD-HGESAYAVYDRFSVGDA 2004

  Fly   376 KELYPLVLLGKFQDNLTPSAGDSLSYHAGAKFSTVDQDNDNCLECNCALRHKGAGWFNNCAKSNL 440
            |..|.|.:.|     .:.:||||::||.|..|||.|:|.|:.: .||||.:|||.|:.||.:.||
Mouse  2005 KSRYKLKVEG-----YSGTAGDSMNYHNGRSFSTYDKDTDSAI-TNCALSYKGAFWYKNCHRVNL 2063

  Fly   441 FGEYTTQNQPGETGIWWDTFSG-QNSLKRVRWMIRP 475
            .|.|...|.  ..|:.|..:.| :.|::.....:||
Mouse  2064 MGRYGDNNH--SQGVNWFHWKGHEYSIQFAEMKLRP 2097

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10359	NP_001137882.1	FReD	267..476	CDD:238040	73/219 (33%)
Tnc	NP_001356140.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	69..91
		EGF_2	222..247	CDD:285248
		EGF_2	345..372	CDD:285248
		EGF_2	377..403	CDD:285248
		EGF_2	408..434	CDD:285248
		EGF_2	468..496	CDD:285248
		EGF_2	504..527	CDD:285248
		EGF_2	533..558	CDD:285248
		EGF_2	592..620	CDD:285248
		FN3	624..710	CDD:238020
		fn3	713..793	CDD:333790
		FN3	804..891	CDD:238020
		fn3	894..976	CDD:333790
		fn3	986..1064	CDD:333790
		fn3	1075..1147	CDD:333790
		fn3	1169..1246	CDD:333790
		fn3	1257..1336	CDD:333790
		fn3	1348..1417	CDD:333790
		fn3	1442..1519	CDD:333790
		fn3	1530..1610	CDD:333790
		fn3	1620..1699	CDD:333790
		fn3	1711..1785	CDD:333790
		fn3	1797..1869	CDD:333790	11/38 (29%)
		Fibrinogen_C	1889..2098	CDD:278572	73/218 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100073
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.710