DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10359 and Fcna

DIOPT Version :9

Sequence 1:	NP_001137882.1	Gene:	CG10359 / 38434	FlyBaseID:	FBgn0035452	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_032021.1	Gene:	Fcna / 14133	MGIID:	1340905	Length:	334	Species:	Mus musculus

Alignment Length:	274	Identity:	96/274 - (35%)
Similarity:	132/274 - (48%)	Gaps:	51/274 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   241 KGLRSTPGQ--------QPIFYGPSGLN-----------------GPTATRQLPSSCSYSFLSNH 280
            :|.:.:||:        :|...||.|:.                 |.|..::.|.||  ..|...
Mouse    70 RGFQGSPGKMGPAGSKGEPGTMGPPGVKGEKGDTGAAPSLGEKELGDTLCQRGPRSC--KDLLTR 132

  Fly   281 GILKVQLT-------PESESFYVSCDED-----WTVILSRTSDDVNFERGWLDYRDGFGNLAGDF 333
            ||.   ||       |:.....|.||.|     |||...|....::|.|.|..|:.|||||..:|
Mouse   133 GIF---LTGWYTIHLPDCRPLTVLCDMDVDGGGWTVFQRRVDGSIDFFRDWDSYKRGFGNLGTEF 194

  Fly   334 FIGLNKLHALTSSALHELRIVMEDFSGNVAYAGYSLFAIGSEKELYPLVLLGKFQDNLTPSAGDS 398
            ::|.:.||.||::...|||:.::||.|..:||.||.|.:..|:|.|.|. ||:|   |..:||||
Mouse   195 WLGNDYLHLLTANGNQELRVDLQDFQGKGSYAKYSSFQVSEEQEKYKLT-LGQF---LEGTAGDS 255

  Fly   399 LSYHAGAKFSTVDQDND-NCLECNCALRHKGAGWFNNCAKSNLFGEYTT-QNQPGETGIWWDTFS 461
            |:.|....|:|.||||| |.:  |||....||.|::||.:|||.|.|.: .::....||.|.|..
Mouse   256 LTKHNNMSFTTHDQDNDANSM--NCAALFHGAWWYHNCHQSNLNGRYLSGSHESYADGINWGTGQ 318

  Fly   462 GQN-SLKRVRWMIR 474
            |.: |.|.....||
Mouse   319 GHHYSYKVAEMKIR 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10359	NP_001137882.1	FReD	267..476	CDD:238040	87/223 (39%)
Fcna	NP_032021.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	47..117		8/46 (17%)
		Collagen	65..106	CDD:189968	7/35 (20%)
		FReD	123..332	CDD:238040	85/219 (39%)
		A domain, contributes to trimerization. /evidence=ECO:0000250	123..162		13/43 (30%)
		B domain, contributes to trimerization. /evidence=ECO:0000250	163..251		38/91 (42%)
		Carbohydrate-binding. /evidence=ECO:0000250\|UniProtKB:O00602	290..292		1/1 (100%)
		P domain. /evidence=ECO:0000250\|UniProtKB:O00602	325..334		3/8 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000029
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100073
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X25
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.710