DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10359 and Fgb

DIOPT Version :9

Sequence 1:	NP_001137882.1	Gene:	CG10359 / 38434	FlyBaseID:	FBgn0035452	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_862897.1	Gene:	Fgb / 110135	MGIID:	99501	Length:	481	Species:	Mus musculus

Alignment Length:	518	Identity:	112/518 - (21%)
Similarity:	186/518 - (35%)	Gaps:	155/518 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 EVPGVTQAPP---------LPPRNLRNNQTRSRIPNNFRSIATPPIAPRCDYKELMTNLH--DRV 80
            |.|.:..|||         .|.:...|.:...|         .||.|..|        ||  ..:
Mouse    45 EPPSLRPAPPPISGGGYRARPAKATANQKKVER---------RPPDAGGC--------LHADTDM 92

  Fly    81 GIL---------VTLDEDQ--RHRLEVIDKKLDQLVESSSARMESMKAQQLDFLHRLDSFEHIQR 134
            |:|         ..|::::  :..:..::..:..:.::||.                 :|:::..
Mouse    93 GVLCPTGCTLQQTLLNQERPIKSSIAELNNNIQSVSDTSSV-----------------TFQYLTL 140

  Fly   135 LSRNTLDELKGETDQVFGPRNV-RELKHKLRNRKKMKDISRTVRDVSQEQYPSSGIGTFNESNLN 198
            |.    |..|.:..||....|| .|....|.:::..  |..||.|                   |
Mouse   141 LK----DMWKKKQAQVKENENVINEYSSILEDQRLY--IDETVND-------------------N 180

  Fly   199 LSSRLDALATLLASTALSVR------SVQVEVANLSRAIRRQSRLIQGKGLRSTPGQQPIFYGPS 257
            :...|..|.::|......::      |.|:|.......:.....::.||..     ::.|..|
Mouse   181 IPLNLRVLRSILEDLRSKIQKLESDISAQMEYCRTPCTVSCNIPVVSGKEC-----EEIIRKG-- 238

  Fly   258 GLNGPTATRQLPSSCSYSFLSNHGILKVQLTPESESFYVSCD-----EDWTVILSRTSDDVNFER 317
               |.|:...|                :|.....:.:.|.||     ..||||.:|....|:|.|
Mouse   239 ---GETSEMYL----------------IQPDTSIKPYRVYCDMKTENGGWTVIQNRQDGSVDFGR 284

  Fly   318 GWLDYRDGFGNLA------------GDFFIGLNKLHALTSSALHELRIVMEDFSGNVAYAGYSLF 370
            .|..|:.||||:|            |::::|.:|:..||.....||.|.|||:.|:...|.|..|
Mouse   285 KWDPYKKGFGNIATNEDAKKYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGF 349

  Fly   371 AIGSEKELYPLVLLGKFQ--------DNLTPSAGD--SLSYHAGAKFSTVDQDNDNCLECN---- 421
            .:.:|...|. |.:.|::        |..:...|:  :::.|.|..|||.|:|||..:..:
Mouse   350 TVQNEASKYQ-VSVNKYKGTAGNALMDGASQLVGENRTMTIHNGMFFSTYDRDNDGWVTTDPRKQ 413

  Fly   422 CALRHKGAGWFNNCAKSNLFGEY--------TTQNQPGETGIWWDTFSGQ-NSLKRVRWMIRP 475
            |:....|..|:|.|..:|..|.|        .......:.|:.|..:.|. .|::|:...|||
Mouse   414 CSKEDGGGWWYNRCHAANPNGRYYWGGLYSWDMSKHGTDDGVVWMNWKGSWYSMRRMSMKIRP 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10359	NP_001137882.1	FReD	267..476	CDD:238040	66/249 (27%)
Fgb	NP_862897.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..81		9/44 (20%)
		Beta-chain polymerization, binding distal domain of another fibrin. /evidence=ECO:0000250	35..37
		Fib_alpha	82..224	CDD:285864	30/191 (16%)
		FReD	227..476	CDD:294064	70/275 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X25
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900