DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eip63E and CDK15

DIOPT Version :9

Sequence 1:	NP_001261373.1	Gene:	Eip63E / 38433	FlyBaseID:	FBgn0005640	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001353315.1	Gene:	CDK15 / 65061	HGNCID:	14434	Length:	435	Species:	Homo sapiens

Alignment Length:	354	Identity:	213/354 - (60%)
Similarity:	255/354 - (72%)	Gaps:	15/354 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 KPPRPKSEVFLNKQETHPR-----RKRFSAFGGDSPFGKQEAYVKLEPLGEGSYATVYKGFSKLT 227
            |.||..|:.|   ||...|     ||..       |||...:|:.||.||||||||||||.|::.
Human    71 KRPRSNSDCF---QEEDLRQGFQWRKSL-------PFGAASSYLNLEKLGEGSYATVYKGISRIN 125

  Fly   228 YQRVALKEIRLQEEEGAPFTAIREASLLKELKHSNIVTLHDIVHTRETLTFVFEYVNTDLSQYME 292
            .|.||||.|.:..|||.||||||||||||.|||:|||.||||:||:|||||||||::|||:|||.
Human   126 GQLVALKVISMNAEEGVPFTAIREASLLKGLKHANIVLLHDIIHTKETLTFVFEYMHTDLAQYMS 190

  Fly   293 KHPGGLDHRNVRLFLFQLLRGLSYCHKRRVLHRDVKPQNLLISDCGELKLADFGLARAKSVPSHT 357
            :|||||...|||||:|||||||:|.|.:.|||||:||||||||..|||||||||||||||:||.|
Human   191 QHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQT 255

  Fly   358 YSHEVVTLWYRPPDVLLGSTEYSTSLDMWGVGCIFVEMVTGMPTFPGIRDTYDQLDKIFKLLGTP 422
            ||.|||||||||||.|||:||||:.||:||.||||:||..|.|.|||:.:..:||:||:::||.|
Human   256 YSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVP 320

  Fly   423 TEDTWPGVTHFPGYKPHKLGFYRPRKLGHNFPRLYDIIEGETIANGFLQLNPEQRLGADDALQHP 487
            ||||||||:..|.|.|.......||.|...:.||..:.|.|.:|:..|:..|..|:.|.:||.|.
Human   321 TEDTWPGVSKLPNYNPEWFPLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHD 385

  Fly   488 YFAQLPKKLYELPDETSIFTVEGVQLYTE 516
            ||:.||.:||:||||.|:|||.||:|..|
Human   386 YFSALPSQLYQLPDEESLFTVSGVRLKPE 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eip63E	NP_001261373.1	PLN00009	203..492	CDD:177649	184/288 (64%)
Eip63E	NP_001261373.1	STKc_PCTAIRE_like	204..489	CDD:270835	182/284 (64%)
CDK15	NP_001353315.1	STKc_PFTAIRE2	102..387	CDD:270852	182/284 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	406	1.000	Domainoid score	I708
eggNOG	1	0.900	-	-		E1_KOG0594
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S747
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1010560at2759
OrthoFinder	1	1.000	-	-		FOG0003670
OrthoInspector	1	1.000	-	-		otm41673
orthoMCL	1	0.900	-	-		OOG6_107080
Panther	1	1.100	-	-	LDO	PTHR24056
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3201
SonicParanoid	1	1.000	-	-		X2541
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.760