DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eip63E and cdk14

DIOPT Version :9

Sequence 1:	NP_001261373.1	Gene:	Eip63E / 38433	FlyBaseID:	FBgn0005640	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	XP_021322413.1	Gene:	cdk14 / 572146	ZFINID:	ZDB-GENE-080220-44	Length:	466	Species:	Danio rerio

Alignment Length:	506	Identity:	258/506 - (50%)
Similarity:	316/506 - (62%)	Gaps:	72/506 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 KKGGALQKLKKRLSHSFGRLTISREDG--DE------STHHHHHHHHHRGGHGGHHNHGNKVPYN 81
            :|.|.::||::.||.||.|:...:|||  ||      ||         |...|..
Zfish    12 QKIGKMKKLRRTLSESFSRIAFKKEDGGFDEICVTKMST---------RSCQGSD---------- 57

  Fly    82 GYNSEEYLDRLEPNGNIPADKTNCRYGAQESAKNDNNKPQDWRSTDSTDHHDRVQRQLSVSSDSK 146
                    ..::|...||.|| ..|....:|.....:||........::::..:..:.|.|.
Zfish    58 --------SVIKPLDTIPEDK-KVRVQRTQSGFEAFDKPASQVKRVHSENNACINAKSSSSG--- 110

  Fly   147 LLDEDIREEMKYHSHVVMRPKKPPRPKSEVFLNKQETHPRRKRFSAFGGDSPFGKQEAYVKLEPL 211
                  :|..|...|  ..|..|..||                         |||.::|.|||.|
Zfish   111 ------KESPKLRRH--SSPSSPTSPK-------------------------FGKADSYEKLEKL 142

  Fly   212 GEGSYATVYKGFSKLTYQRVALKEIRLQEEEGAPFTAIREASLLKELKHSNIVTLHDIVHTRETL 276
            |||||||||||.||:..:.||||.||||||||.||||||||||||.|||:|||.||||:||:|||
Zfish   143 GEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETL 207

  Fly   277 TFVFEYVNTDLSQYMEKHPGGLDHRNVRLFLFQLLRGLSYCHKRRVLHRDVKPQNLLISDCGELK 341
            |.|||||:|||.|||:||||||...|||||||||||||||.|:|.:||||:|||||||||.||||
Zfish   208 TLVFEYVHTDLCQYMDKHPGGLQPDNVRLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELK 272

  Fly   342 LADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTSLDMWGVGCIFVEMVTGMPTFPGIR 406
            ||||||||||||||||||:|||||||||||||||||:|||.|||||||||||||:.|:..|||::
Zfish   273 LADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTDYSTCLDMWGVGCIFVEMIQGVAAFPGMK 337

  Fly   407 DTYDQLDKIFKLLGTPTEDTWPGVTHFPGYKPHKLGFYRPRKLGHNFPRLYDIIEGETIANGFLQ 471
            |..|||::||.:||||:|:|||||...|.:||.:...|.|:||...:.:|..:...|.:|:.|||
Zfish   338 DIQDQLERIFLVLGTPSEETWPGVHSLPHFKPDRFTVYSPKKLRQAWNKLGYVDHAEELASRFLQ 402

  Fly   472 LNPEQRLGADDALQHPYFAQLPKKLYELPDETSIFTVEGVQLYTEPNRQNK 522
            ..|::||.|..||.|.||:.||.:|:||||.:|||||.||:|.:|....:|
Zfish   403 CFPKKRLSAQAALHHEYFSHLPSRLWELPDMSSIFTVAGVKLQSESGDSSK 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eip63E	NP_001261373.1	PLN00009	203..492	CDD:177649	202/288 (70%)
Eip63E	NP_001261373.1	STKc_PCTAIRE_like	204..489	CDD:270835	200/284 (70%)
cdk14	XP_021322413.1	STKc_PCTAIRE_like	135..420	CDD:270835	200/284 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0594
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7888
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1010560at2759
OrthoFinder	1	1.000	-	-		FOG0003670
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_107080
Panther	1	1.100	-	-	O	PTHR24056
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2541
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.780