DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eip63E and cdk16

DIOPT Version :9

Sequence 1:	NP_001261373.1	Gene:	Eip63E / 38433	FlyBaseID:	FBgn0005640	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	XP_021334043.1	Gene:	cdk16 / 559750	ZFINID:	ZDB-GENE-030131-2939	Length:	537	Species:	Danio rerio

Alignment Length:	540	Identity:	239/540 - (44%)
Similarity:	316/540 - (58%)	Gaps:	68/540 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LQKLKKRLSHSF-----GRLTISREDGDESTHHHHHHH------------HHRGGHGGHHNHGNK 77
            ::|:|::||.:.     |..::|.....:.|..|....            ..||..|....|...
Zfish     4 MRKIKRQLSLTLRGGNSGDKSLSETISSQDTGAHSDSEAMPVGGSGGLRGSVRGSGGSFSMHSLL 68

  Fly    78 VPYN---------GYNSEEYLD---RLEPNGNIPADKTNCRYGAQESAKNDNNKPQDWRSTDSTD 130
            ..|:         |.:...||:   |||.              ..|..|..::...|..|..|:|
Zfish    69 QSYSSALRRPRSLGRSLSSYLNHTTRLEI--------------VHEDVKMGSDGESDQASATSSD 119

  Fly   131 H-HDRVQRQLSVSSDSKLLDEDIREEMKYHSHVVMRPKKPPRP---------KSEVFLNKQETHP 185
            . |..|:.:|..:...|:..|||.:.:...:.:.:       |         .|.:|........
Zfish   120 EVHSPVRVRLRNNPGRKISTEDINKRLSLPADIRL-------PDGYLEKFSLNSPLFDKPLSRRL 177

  Fly   186 RRKRFSAFGGDSPFGKQEAYVKLEPLGEGSYATVYKGFSKLTYQRVALKEIRLQEEEGAPFTAIR 250
            ||...|..|    |||.|.||||:.||||:|||||||.||||...||||||||:.|||||.||||
Zfish   178 RRVSLSEIG----FGKLETYVKLDKLGEGTYATVYKGRSKLTDNLVALKEIRLEHEEGAPCTAIR 238

  Fly   251 EASLLKELKHSNIVTLHDIVHTRETLTFVFEYVNTDLSQYMEKHPGGLDHRNVRLFLFQLLRGLS 315
            |.||||:|||:||||||||:||:::||.||||::.||.||::.....:...||:||||||||||:
Zfish   239 EVSLLKDLKHANIVTLHDIIHTQKSLTLVFEYLDKDLKQYLDDCGNSIHMHNVKLFLFQLLRGLN 303

  Fly   316 YCHKRRVLHRDVKPQNLLISDCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYS 380
            |||:|:|||||:|||||||:|.|||||||||||||||:|:.|||:|||||||||||:|||||:||
Zfish   304 YCHRRKVLHRDLKPQNLLINDRGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYS 368

  Fly   381 TSLDMWGVGCIFVEMVTGMPTFPGIRDTYDQLDKIFKLLGTPTEDTWPGVTHFPGYKPHKLGFYR 445
            |.:|||||||||.||.||.|.||| ....::|..||||||||||:||||:|....:..:....||
Zfish   369 TQIDMWGVGCIFYEMSTGRPLFPG-STVEEELHFIFKLLGTPTEETWPGITSNEEFISYNYPRYR 432

  Fly   446 PRKLGHNFPRLYDIIEGETIANGFLQLNPEQRLGADDALQHPYFAQLPKKLYELPDETSIFTVEG 510
            ...|.::.|||.:  :|..:.:..||...::|:.|::|::||||..|.::|..|||.||||.::.
Zfish   433 ADCLHNHTPRLDN--DGVELLSKLLQFEGKKRIAAEEAMRHPYFHCLGERLLTLPDTTSIFALQE 495

  Fly   511 VQLYTEPN-RQNKXKLKQVL 529
            :||..||. |.|. ...::|
Zfish   496 IQLEKEPGMRTNSLSESELL 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eip63E	NP_001261373.1	PLN00009	203..492	CDD:177649	181/288 (63%)
Eip63E	NP_001261373.1	STKc_PCTAIRE_like	204..489	CDD:270835	178/284 (63%)
cdk16	XP_021334043.1	STKc_PCTAIRE1	190..486	CDD:270854	184/298 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1010560at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3201
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.950