DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eip63E and Cdk1

DIOPT Version :9

Sequence 1:	NP_001261373.1	Gene:	Eip63E / 38433	FlyBaseID:	FBgn0005640	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_062169.1	Gene:	Cdk1 / 54237	RGDID:	2319	Length:	297	Species:	Rattus norvegicus

Alignment Length:	307	Identity:	144/307 - (46%)
Similarity:	197/307 - (64%)	Gaps:	21/307 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   203 EAYVKLEPLGEGSYATVYKGFSKLTYQRVALKEIRLQ-EEEGAPFTAIREASLLKELKHSNIVTL 266
            |.|:|:|.:|||:|..||||..:.|.|.||:|:|||: ||||.|.|||||.||||||:|.|||:|
  Rat     2 EDYIKIEKIGEGTYGVVYKGRHRTTGQIVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSL 66

  Fly   267 HDIVHTRETLTFVFEYVNTDLSQYMEKHPGG--LDHRNVRLFLFQLLRGLSYCHKRRVLHRDVKP 329
            .|::.....|..:||:::.||.:|::..|.|  :|...|:.:|:|:|:|:.:||.|||||||:||
  Rat    67 QDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQFMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKP 131

  Fly   330 QNLLISDCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTSLDMWGVGCIFVE 394
            |||||.|.|.:||||||||||..:|...|:|||||||||.|:|||||..|||.:|:|.:|.||.|
  Rat   132 QNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAE 196

  Fly   395 MVTGMPTFPGIRDTYDQLDKIFKLLGTPTEDTWPGV-------THFPGYKPHKLGFYRPRKLGHN 452
            :.|..|.|.|..: .|||.:||:.||||..:.||.|       ..||.:||..|..: .:.|..|
  Rat   197 LATKKPLFHGDSE-IDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASH-VKNLDEN 259

  Fly   453 FPRLYDIIEGETIANGFLQLNPEQRLGADDALQHPYFAQLPKKLYEL 499
                     |..:.:..|..:|.:|:....||:||||..|..::.::
  Rat   260 ---------GLDLLSKMLVYDPAKRISGKMALKHPYFDDLDNQIKKM 297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eip63E	NP_001261373.1	PLN00009	203..492	CDD:177649	143/298 (48%)
Eip63E	NP_001261373.1	STKc_PCTAIRE_like	204..489	CDD:270835	140/294 (48%)
Cdk1	NP_062169.1	STKc_CDK1_euk	3..287	CDD:270845	140/294 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0594
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1010560at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820