Protein Alignment Eip63E and CDK18

DIOPT Version :10

• Sequence 1: NP_001261373.1
• Gene: Eip63E / 38433
• FlyBaseID: FBgn0005640
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: XP_054192892.1
• Gene: CDK18 / 5129
• HGNCID: 8751
• Length: 574
• Species: Homo sapiens
• Alignment Length: 510
• Identity: 222/510 - (43%)
• Similarity: 290/510 - (56%)
• Gaps: 50/510 - (9%)

  Fly    30 LQKLKKRLSHSFGRLTISREDGDESTHHHHHHHHHRG-----GHGGHHNHGNKVPYNGYNSEEYL 89
            ::..|:|.|.|..|.....|...|.|...:..|:.|.     |..|.........::..:|.|..
Human    74 MKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNENLQLGPLGRDPPQECSTFSPTDSGEEP 138

  Fly    90 DRLEPNGNIPADKTNCRYGAQESAKNDNNKPQDWRSTDSTDHHDR---------VQRQLSVSSDS 145
            .:|.|.......:...|:..:..|  ....|:..........|.|         |.::||
Human   139 GQLSPGVQFQRRQNQRRFSMEVRA--SGALPRQVAGCTHKGVHRRAAALQPDFDVSKRLS----- 196

  Fly   146 KLLDEDIREEMKYHSHVVMRPKKPPRPKSEVFLNKQETHPRRKRFSAFGGDSPFGKQEAYVKLEP 210
              |..|||...::...:.|.....|:|.|.:        .||...|..|    |||.|.||||:.
Human   197 --LPMDIRLPQEFLQKLQMESPDLPKPLSRM--------SRRASLSDIG----FGKLETYVKLDK 247

  Fly   211 LGEGSYATVYKGFSKLTYQRVALKEIRLQEEEGAPFTAIREASLLKELKHSNIVTLHDIVHTRET 275
            ||||:||||:||.||||...||||||||:.|||||.|||||.||||.|||:|||||||::||..:
Human   248 LGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRS 312

  Fly   276 LTFVFEYVNTDLSQYMEKHPGGL-DHRNVRLFLFQLLRGLSYCHKRRVLHRDVKPQNLLISDCGE 339
            ||.||||:::||.||:: |.|.| ...||::|:|||||||:|||.|::||||:|||||||::.||
Human   313 LTLVFEYLDSDLKQYLD-HCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGE 376

  Fly   340 LKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTSLDMWGVGCIFVEMVTGMPTFPG 404
            |||||||||||||||:.|||:|||||||||||||||||||||.:||||||||..||.||.|.|||
Human   377 LKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPG 441

  Fly   405 IRDTYDQLDKIFKLLGTPTEDTWPGVTHFPGYKPHKLGFYRPRKLGHNFPRLYDIIEGETIANGF 469
             ....::|..||:|||||||:||||||.|..::.:....|.|:.|.::.|||  ..:|..:.:..
Human   442 -STVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRL--DTDGIHLLSSL 503

  Fly   470 LQLN-----PEQRLGADDALQHPYFAQLPKKLYELPDETSIFTVEGVQLYTEPNR 519
            |.::     |.:| .....:..|:....|:.|:.:    .:...|...||:.|.|
Human   504 LLVSVLPAGPRER-QPKSQVPVPHAGPTPQLLWLV----CLHVFETSPLYSPPPR 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eip63E	NP_001261373.1	STKc_PCTAIRE_like	204..489	CDD:270835	175/290 (60%)
CDK18	XP_054192892.1	Protein Kinases, catalytic domain	236..498	CDD:473864	175/265 (66%)