Protein Alignment Eip63E and CDK18

DIOPT Version :9

• Sequence 1: NP_001261373.1
• Gene: Eip63E / 38433
• FlyBaseID: FBgn0005640
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: XP_016856912.1
• Gene: CDK18 / 5129
• HGNCID: 8751
• Length: 572
• Species: Homo sapiens
• Alignment Length: 503
• Identity: 228/503 - (45%)
• Similarity: 299/503 - (59%)
• Gaps: 40/503 - (7%)

  Fly    30 LQKLKKRLSHSFGRLTISREDGDESTHHHHHHHHHRG-----GHGGHHNHGNKVPYNGYNSEEYL 89
            ::..|:|.|.|..|.....|...|.|...:..|:.|.     |..|.........::..:|.|..
Human    74 MKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNENLQLGPLGRDPPQECSTFSPTDSGEEP 138

  Fly    90 DRLEPNGNIPADKTNCRYGAQESAKNDNNKPQDWRSTDSTDHHDR---------VQRQLSVSSDS 145
            .:|.|.......:...|:..:..|  ....|:..........|.|         |.::||
Human   139 GQLSPGVQFQRRQNQRRFSMEVRA--SGALPRQVAGCTHKGVHRRAAALQPDFDVSKRLS----- 196

  Fly   146 KLLDEDIREEMKYHSHVVMRPKKPPRPKSEVFLNKQETHPRRKRFSAFGGDSPFGKQEAYVKLEP 210
              |..|||...::...:.|.....|:|.|.:        .||...|..|    |||.|.||||:.
Human   197 --LPMDIRLPQEFLQKLQMESPDLPKPLSRM--------SRRASLSDIG----FGKLETYVKLDK 247

  Fly   211 LGEGSYATVYKGFSKLTYQRVALKEIRLQEEEGAPFTAIREASLLKELKHSNIVTLHDIVHTRET 275
            ||||:||||:||.||||...||||||||:.|||||.|||||.||||.|||:|||||||::||..:
Human   248 LGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRS 312

  Fly   276 LTFVFEYVNTDLSQYMEKHPGGL-DHRNVRLFLFQLLRGLSYCHKRRVLHRDVKPQNLLISDCGE 339
            ||.||||:::||.||:: |.|.| ...||::|:|||||||:|||.|::||||:|||||||::.||
Human   313 LTLVFEYLDSDLKQYLD-HCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGE 376

  Fly   340 LKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTSLDMWGVGCIFVEMVTGMPTFPG 404
            |||||||||||||||:.|||:|||||||||||||||||||||.:||||||||..||.||.|.|||
Human   377 LKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPG 441

  Fly   405 IRDTYDQLDKIFKLLGTPTEDTWPGVTHFPGYKPHKLGFYRPRKLGHNFPRLYDIIEGETIANGF 469
             ....::|..||:|||||||:||||||.|..::.:....|.|:.|.::.|||  ..:|..:.:..
Human   442 -STVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRL--DTDGIHLLSSL 503

  Fly   470 LQLNPEQRLGADDALQHPYFAQLPKKLYELPDETSIFTVEGVQLYTEP 517
            |....:.|:.|:.||.|.||..|.:::::|.|..|||:::.:||..:|
Human   504 LLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEIQLQKDP 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eip63E	NP_001261373.1	PLN00009	203..492	CDD:177649	180/289 (62%)
		STKc_PCTAIRE_like	204..489	CDD:270835	177/285 (62%)
CDK18	XP_016856912.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0594
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1010560at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820