Protein Alignment Eip63E and CDK17

DIOPT Version :10

• Sequence 1: NP_001261373.1
• Gene: Eip63E / 38433
• FlyBaseID: FBgn0005640
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_002586.2
• Gene: CDK17 / 5128
• HGNCID: 8750
• Length: 523
• Species: Homo sapiens
• Alignment Length: 538
• Identity: 236/538 - (43%)
• Similarity: 316/538 - (58%)
• Gaps: 79/538 - (14%)

  Fly    30 LQKLKKRLSHSF-GRLTISR-----------------------EDGDESTHHHHHH--HHHRGGH 68
            ::|.|:|||.:. |..||..                       ::|...|.|..|.  |.:.|..
Human     1 MKKFKRRLSLTLRGSQTIDESLSELAEQMTIEENSSKDNEPIVKNGRPPTSHSMHSFLHQYTGSF 65

  Fly    69 ------------GGHHNHGNKVPYNGYNSEEYLDRLEPNGNIPADKTNCRYGAQESAKNDNNKPQ 121
                        ||.......:|.||    ..||.:..|..:.:|        .||.:.......
Human    66 KKPPLRRPHSVIGGSLGSFMAMPRNG----SRLDIVHENLKMGSD--------GESDQASGTSSD 118

  Fly   122 DWRSTDSTDHHDRVQRQLSVSSDSKLLD--EDIR------EEMKYHSHVVMRPKKPPRPKSEVFL 178
            :.:|.......:|:.|::|:...:|.|.  .|||      |:::.:|        ||      |.
Human   119 EVQSPTGVCLRNRIHRRISMEDLNKRLSLPADIRIPDGYLEKLQINS--------PP------FD 169

  Fly   179 NKQETHPRRKRFSAFGGDSPFGKQEAYVKLEPLGEGSYATVYKGFSKLTYQRVALKEIRLQEEEG 243
            .......||...|..|    |||.|.|:|||.||||:|||||||.||||...||||||||:.|||
Human   170 QPMSRRSRRASLSEIG----FGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEG 230

  Fly   244 APFTAIREASLLKELKHSNIVTLHDIVHTRETLTFVFEYVNTDLSQYMEKHPGGLDHRNVRLFLF 308
            ||.|||||.||||:|||:|||||||||||.::||.||||::.||.|||:.....:...||:|||:
Human   231 APCTAIREVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLY 295

  Fly   309 QLLRGLSYCHKRRVLHRDVKPQNLLISDCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVL 373
            |:||||:|||:|:|||||:|||||||::.|||||||||||||||||:.|||:|||||||||||||
Human   296 QILRGLAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360

  Fly   374 LGSTEYSTSLDMWGVGCIFVEMVTGMPTFPGIRDTYDQLDKIFKLLGTPTEDTWPGVTHFPGYKP 438
            |||:||||.:|||||||||.||.:|.|.||| ....|:|..||:|||||:::||||::....:|.
Human   361 LGSSEYSTQIDMWGVGCIFFEMASGRPLFPG-STVEDELHLIFRLLGTPSQETWPGISSNEEFKN 424

  Fly   439 HKLGFYRPRKLGHNFPRLYDIIEGETIANGFLQLNPEQRLGADDALQHPYFAQLPKKLYELPDET 503
            :....|:|:.|.::.|||..  ||..:...|||...::|:.|::|::|.||..|..:::.||:..
Human   425 YNFPKYKPQPLINHAPRLDS--EGIELITKFLQYESKKRVSAEEAMKHVYFRSLGPRIHALPESV 487

  Fly   504 SIFTVEGVQLYTEPNRQN 521
            |||:::.:||..:|..:|
Human   488 SIFSLKEIQLQKDPGFRN 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eip63E	NP_001261373.1	STKc_PCTAIRE_like	204..489	CDD:270835	177/284 (62%)
CDK17	NP_002586.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	30..55		3/24 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	103..123		3/27 (11%)
		STKc_PCTAIRE2	185..493	CDD:143377	190/314 (61%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	501..523		2/5 (40%)