DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eip63E and cdk18

DIOPT Version :9

Sequence 1:	NP_001261373.1	Gene:	Eip63E / 38433	FlyBaseID:	FBgn0005640	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001006837.1	Gene:	cdk18 / 448581	XenbaseID:	XB-GENE-489094	Length:	462	Species:	Xenopus tropicalis

Alignment Length:	507	Identity:	233/507 - (45%)
Similarity:	302/507 - (59%)	Gaps:	80/507 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LQKLKKRLSHSFGRLTISREDGDESTHHHHHHHHHRGGHGGHHNHGNKVPYNGYNSEEYLDRLEP 94
            ::..|:|.|     |::.|.:    |...::..:.|.|.|..|:|                 |:.
Frog     4 VKNFKRRFS-----LSVPRPE----TIEEYNQLNSRCGEGLGHSH-----------------LQV 42

  Fly    95 NGNIPADKTNCRYGAQESAKNDNNKPQDWRSTDST--DHHDRVQRQLSVSSDSKLLD--EDIR-- 153
                          ||.|..|....|.|......|  .:...|||:||:...||.|.  .|||
Frog    43 --------------AQLSPGNAALSPSDGEGLSPTALSYRKTVQRRLSMEDVSKRLSLPMDIRLP 93

  Fly   154 ----EEMKYHSHVVMRPKKPPRPKSEVFLNKQETHPRRKRFSAFGGDSPFGKQEAYVKLEPLGEG 214
                ::::.:|     |...|:|.|.:.        ||...|..|    |||.|.|:||:.||||
Frog    94 PELLDKLQMNS-----PDDDPKPLSRLL--------RRASLSDIG----FGKLETYIKLDKLGEG 141

  Fly   215 SYATVYKGFSKLTYQRVALKEIRLQEEEGAPFTAIREASLLKELKHSNIVTLHDIVHTRETLTFV 279
            :||||:||.||||...||||||||:.|||||.|||||.||||.||||||||||||:||...||.|
Frog   142 TYATVFKGRSKLTGNLVALKEIRLEHEEGAPCTAIREVSLLKNLKHSNIVTLHDIIHTEYCLTLV 206

  Fly   280 FEYVNTDLSQYMEKHPGGLDHRNVRLFLFQLLRGLSYCHKRRVLHRDVKPQNLLISDCGELKLAD 344
            |||:::||.||::.....:...||::|:|||||||||||:|::||||:|||||||::.|||||||
Frog   207 FEYLDSDLKQYLDNCGNLMCMHNVKIFMFQLLRGLSYCHRRKILHRDLKPQNLLINEKGELKLAD 271

  Fly   345 FGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTSLDMWGVGCIFVEMVTGMPTFPGIRDTY 409
            ||||||||||:.|||:|||||||||||||||||||||.:||||||||..||.||.|.||| ....
Frog   272 FGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCILYEMATGRPMFPG-STVK 335

  Fly   410 DQLDKIFKLLGTPTEDTWPGV---THFPGYKPHKLGF--YRPRKLGHNFPRLYDIIEGETIANGF 469
            ::|..||:|||||||:||||:   ..|.||     ||  ||.:.|.::.|||..  :|..:.:..
Frog   336 EELHLIFRLLGTPTEETWPGICSNKEFKGY-----GFPQYRTQPLKNHTPRLDS--DGIDLLSSL 393

  Fly   470 LQLNPEQRLGADDALQHPYFAQLPKKLYELPDETSIFTVEGVQLYTEPNRQN 521
            |....::|:.||..|:|.||..:..::..|||..||||::.:||..:|..::
Frog   394 LLYEDKKRISADMGLRHAYFKTMGDRVLTLPDNASIFTLKEIQLQKDPGHRS 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eip63E	NP_001261373.1	PLN00009	203..492	CDD:177649	181/293 (62%)
Eip63E	NP_001261373.1	STKc_PCTAIRE_like	204..489	CDD:270835	178/289 (62%)
cdk18	NP_001006837.1	STKc_PCTAIRE3	126..413	CDD:270853	182/294 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1010560at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010