Protein Alignment Eip63E and Cdk12

DIOPT Version :9

• Sequence 1: NP_001261373.1
• Gene: Eip63E / 38433
• FlyBaseID: FBgn0005640
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_001262167.1
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Alignment Length: 599
• Identity: 167/599 - (27%)
• Similarity: 256/599 - (42%)
• Gaps: 150/599 - (25%)

  Fly     9 TTTGATNAKDGVTMREKKGGALQKLKKRL-----SHSFGRLTISREDGDESTHHHHHHHHHRGGH 68
            |:..|...||    |.|:..||:::.:|.     |:|.|.|||
  Fly   552 TSLFAELVKD----RHKRQKALKEIIERQEENSNSNSNGALTI---------------------- 590

  Fly    69 GGHHNHGNKVPYNGYNSEEYLDRLEPNGNIPADKTNCRYGAQE-SAKND---NNKPQDWRSTDS- 128
               :::.:.|..|..|:.:  .|..|....||..:....|.|. .:|.|   ||.|...:..||
  Fly   591 ---NDNSSSVDGNTPNAAD--GRSAPGSGTPAAASTTSNGLQALGSKPDLDLNNIPMPNKQNDSV 650

  Fly   129 -------TDHHDRVQR-----------------------QLSVSSDSKLLD-------------- 149
                   .|..|.|.:                       .|.:.....:||
  Fly   651 VSNPASNADVPDSVAQLKQPLLVPPFSASKNNIKPKSLTSLPLPPGMNVLDLAGARSPSPGQKKE 715

  Fly   150 ---EDIREEMKYHSHVVMRPKKPPRPKSEVFLNKQETHPRRKRFSA--------FGG-------- 195
               :::......:..|:..|..|..|.||......:.....:.|.|        .||
  Fly   716 SDEKNVTSSGSANKSVLNLPMPPVIPGSEELSGDDDVIDSPEDFDAPAVGTVHGHGGGPGTTRQR 780

  Fly   196 -------DS-----PFGKQ--EAYVKLEPLGEGSYATVYKGFSKLTYQRVALKEIRLQ-EEEGAP 245
                   ||     .:|::  :.:..:..:|||:|..|||.....|...||||::||: |:||.|
  Fly   781 PVILNRRDSRNNVRDWGERCVDVFEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFP 845

  Fly   246 FTAIREASLLKELKHSNIVTLHDIVHTRE----------TLTFVFEYVNTDLSQYMEKHPGGLDH 300
            .||:||..:|::|.|.|||.||:||..::          :...||||::.||...:|......:.
  Fly   846 ITAVREIKILRQLNHRNIVNLHEIVTDKQDAVEFRKDKGSFYLVFEYMDHDLMGLLESGMVDFNE 910

  Fly   301 RNVRLFLFQLLRGLSYCHKRRVLHRDVKPQNLLISDCGELKLADFGLARAKSVP--SHTYSHEVV 363
            .|....:.|||.||:||||:..||||:|..|:|:::.|::|||||||||..:..  ...|:::|:
  Fly   911 ENNASIMKQLLDGLNYCHKKNFLHRDIKCSNILMNNRGKVKLADFGLARLYNADDRERPYTNKVI 975

  Fly   364 TLWYRPPDVLLGSTEYSTSLDMWGVGCIFVEMVTGMPTFPGIRDTYDQLDKIFKLLGTPTEDTWP 428
            |||||||::|||...|..|:|:|..|||..|:....|.|....: ..||:.|.|:.|:|....||
  Fly   976 TLWYRPPELLLGEERYGPSIDVWSCGCILGELFVKRPLFQANAE-MAQLETISKICGSPVPAVWP 1039

  Fly   429 GVTHFPGYKPHKLGFYRPRKLGHNF-----PRLYDIIEGETIANGFLQLNPEQRLGADDALQHPY 488
            .|...|.:...|......|:|..:|     |.| |:::      ..|.|:|::|:.|:|||:.|:
  Fly  1040 NVIKLPLFHTLKQKKTHRRRLREDFEFMPAPAL-DLLD------KMLDLDPDKRITAEDALRSPW 1097

  Fly   489 FAQLPKKLYELPDE 502
            ..::.      |||
  Fly  1098 LRKIN------PDE 1105

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eip63E	NP_001261373.1	PLN00009	203..492	CDD:177649	114/306 (37%)
		STKc_PCTAIRE_like	204..489	CDD:270835	114/302 (38%)
Cdk12	NP_001262167.1	STKc_CDK12	796..1098	CDD:270847	115/309 (37%)
		S_TKc	804..1098	CDD:214567	114/301 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442442
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24056
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940