DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eip63E and Cdk14

DIOPT Version :9

Sequence 1:	NP_001261373.1	Gene:	Eip63E / 38433	FlyBaseID:	FBgn0005640	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001382511.1	Gene:	Cdk14 / 362316	RGDID:	1305544	Length:	469	Species:	Rattus norvegicus

Alignment Length:	508	Identity:	248/508 - (48%)
Similarity:	310/508 - (61%)	Gaps:	88/508 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 KKGGALQKLKKRLSHSFGRLTISREDG--DE------STHHHHHHHHHRGGHGGHHNHGNKVPYN 81
            :|.|.::||::.||.||.|:.:.::|.  ||      ||.:                      ..
  Rat    11 EKIGKMKKLRRTLSESFSRIALKKDDTTFDEICVTKMSTRN----------------------CQ 53

  Fly    82 GYNSE-EYLDRLEPNGNIPADKTNCRYGAQESAKN-------DNNKPQDWRSTDSTDHHDRVQRQ 138
            |.:|. ::||.:..:..:...:|...:...|...|       :||...:::|:.:.....:|:|.
  Rat    54 GMDSVIKHLDTIPEDKKVRVQRTQSTFDPFEKPANQVKRVHSENNACINFKSSAAGKESPKVRRH 118

  Fly   139 LSVSSDSKLLDEDIREEMKYHSHVVMRPKKPPRPKSEVFLNKQETHPRRKRFSAFGGDSPFGKQE 203
            .|                         |..|..||                         |||.:
  Rat   119 SS-------------------------PSSPTSPK-------------------------FGKAD 133

  Fly   204 AYVKLEPLGEGSYATVYKGFSKLTYQRVALKEIRLQEEEGAPFTAIREASLLKELKHSNIVTLHD 268
            :|.|||.||||||||||||.||:..:.||||.||||||||.||||||||||||.|||:|||.|||
  Rat   134 SYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHD 198

  Fly   269 IVHTRETLTFVFEYVNTDLSQYMEKHPGGLDHRNVRLFLFQLLRGLSYCHKRRVLHRDVKPQNLL 333
            |:||:||||.|||||:|||.|||:||||||...||:||||||||||||.|:|.:||||:||||||
  Rat   199 IIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLL 263

  Fly   334 ISDCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTSLDMWGVGCIFVEMVTG 398
            |||.||||||||||||||||||||||:|||||||||||||||||||||.|||||||||||||:.|
  Rat   264 ISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQG 328

  Fly   399 MPTFPGIRDTYDQLDKIFKLLGTPTEDTWPGVTHFPGYKPHKLGFYRPRKLGHNFPRLYDIIEGE 463
            :..|||::|..|||::||.:||||.|||||||...|.:||.:...|..:.|...:.:|..:...|
  Rat   329 VAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTVYSSKSLRQAWNKLSYVNHAE 393

  Fly   464 TIANGFLQLNPEQRLGADDALQHPYFAQLPKKLYELPDETSIFTVEGVQLYTE 516
            .:|:..||.:|:.||.|..||.|.||:.||.:|:||.|.:|||||..|:|..|
  Rat   394 DLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPE 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eip63E	NP_001261373.1	PLN00009	203..492	CDD:177649	200/288 (69%)
Eip63E	NP_001261373.1	STKc_PCTAIRE_like	204..489	CDD:270835	198/284 (70%)
Cdk14	NP_001382511.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7888
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1010560at2759
OrthoFinder	1	1.000	-	-		FOG0003670
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_107080
Panther	1	1.100	-	-	O	PTHR24056
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2541
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.920