Protein Alignment Eip63E and cdk-12

DIOPT Version :10

• Sequence 1: NP_001261373.1
• Gene: Eip63E / 38433
• FlyBaseID: FBgn0005640
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_001367220.1
• Gene: cdk-12 / 175559
• WormBaseID: WBGene00007135
• Length: 734
• Species: Caenorhabditis elegans
• Alignment Length: 636
• Identity: 171/636 - (26%)
• Similarity: 248/636 - (38%)
• Gaps: 206/636 - (32%)

  Fly    23 REKKGGALQKLKKRLSHSFGRLTISREDGDESTHHHHHHHHHRGGHGGHHNHGNKVPYNGYNSEE 87
            ::|:|.:.|.::.|          .|:..|..:..:...:..|||.||..:.|.       |...
 Worm    37 KDKRGSSRQGVRPR----------DRDSKDSISPQYKQRNWSRGGGGGGRDRGR-------NDFS 84

  Fly    88 YLDRLEPNGNIPADKTNCRYGAQESAKNDNNKPQDWRSTDSTDHHD---------RVQRQLSVSS 143
            |                     ::..| |.||.:|.||...:.|..         ..:|..|.||
 Worm    85 Y---------------------RKKGK-DYNKRRDKRSRSRSRHRSPKRSGSSKKSKRRNSSGSS 127

  Fly   144 DSKLLDEDIREEMKYHSH----------------------------------------------- 161
            .|.|:|..:..|:|.|..
 Worm   128 SSDLMDTSLMSELKKHGDYGSSSKSKKKSRKRRKHSSSSSSSSGEAMDLPVSSNGMNVTAIPPPP 192

  Fly   162 ---------VVMRPKKPPRPKSEVFLNKQETHPRRKRFSAF------------------------ 193
                     :..:|..||.|.:..|:    |.|.|...:.|
 Worm   193 SFNINPFQPMFSQPPPPPLPPNSQFM----TPPPRPPPAPFSIPPPSVDIHFAATASFSLSSIPP 253

  Fly   194 ------GGDSPFGKQEA----------------------------------------YVKLEPLG 212
                  ||.|...:|:.                                        |..|:.:|
 Worm   254 PPPQTDGGASSSKRQDPLPMPPDSKRIATRPVITTRRGHATNRPSDSDSWYKTNLTHYTMLDQIG 318

  Fly   213 EGSYATVYKGFSKLTYQRVALKEIRLQ-EEEGAPFTAIREASLLKELKHSNIVTLHDIV------ 270
            ||:|..|||..:.||.::||||.:||: |:||.|.|||||..:|::|.|.|||.|.|||
 Worm   319 EGTYGQVYKAVNNLTGEQVALKRVRLENEKEGFPITAIREIKILRQLHHKNIVRLMDIVIDDISM 383

  Fly   271 ----HTRETLTFVFEYVNTDLSQYME-KHPGGLDHRNVRLFLFQLLRGLSYCHKRRVLHRDVKPQ 330
                .||.....|||||:.||...:| |.....:...:.....|||.||:|.|....||||:|..
 Worm   384 DELKRTRANFYLVFEYVDHDLIGLLESKELVDFNKDQICSLFKQLLEGLAYIHNTGFLHRDIKCS 448

  Fly   331 NLLISDCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTSLDMWGVGCIFVEM 395
            |:|:::.||||:||.||||.....|..|::.|:|||||||::|||...|..::|:|..||:..|:
 Worm   449 NILVNNKGELKIADLGLARLWEKESRLYTNRVITLWYRPPELLLGDERYGPAIDVWSTGCMLGEL 513

  Fly   396 VTGMPTFPGIRDTYDQLDKIFKLLGTPTEDTWPGVTHFPGYKPHKLGFYRPRKLGHNF----PRL 456
            .|..|.|.| .:.:.||:.|.|:.|:|..|.||.:|...|:...::.....|::...|    ||
 Worm   514 FTRKPLFNG-NNEFGQLELISKVCGSPNVDNWPELTELVGWNTFRMKRTYQRRIREEFEHIMPR- 576

  Fly   457 YDIIEGETIANGFLQLNPEQRLGADDALQHPYFAQL------PKKLYELPD 501
                |...:.:..|.||||:|:.|.:||.||:...|      |.||.:..|
 Worm   577 ----EAVDLLDKMLTLNPEKRISAKEALNHPWIRSLEHTTVQPLKLPQHQD 623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eip63E	NP_001261373.1	STKc_PCTAIRE_like	204..489	CDD:270835	121/340 (36%)
cdk-12	NP_001367220.1	STKc_CDK12	303..605	CDD:270847	121/307 (39%)