Protein Alignment Eip63E and Cdk12

DIOPT Version :10

• Sequence 1: NP_001261373.1
• Gene: Eip63E / 38433
• FlyBaseID: FBgn0005640
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: XP_061498912.1
• Gene: Cdk12 / 1278447
• VectorBaseID: AGAMI1_003914
• Length: 1490
• Species: Anopheles gambiae
• Alignment Length: 471
• Identity: 152/471 - (32%)
• Similarity: 235/471 - (49%)
• Gaps: 75/471 - (15%)

  Fly    69 GGHHNHGNKVPYNGYN-------------SEEYLDRLEPNGN--IPADK---TNCRYGAQESAKN 115
            |.|......||.:|..             ..|.|...|..|:  :|:::   .|.....|....|
Mosquito   989 GAHATTSTAVPGSGIKKGLLNLPMPPMVPGSEDLSGEEDIGSPLLPSNRDTIQNLTPSGQTGVAN 1053

  Fly   116 DNNKPQDWRSTDSTDHHDRVQ----RQLSVSSDSKLLDEDIREEMKYHSHVVMRPKKPPRPKSEV 176
            :||        ::|..::|.:    ...||:|.::          :........|...||
Mosquito  1054 NNN--------NNTSLNNRYKGVGTATSSVASSAQ----------QSTGGAGKAPVARPR----- 1095

  Fly   177 FLNKQETHPRRKRFSAFGGDSPFGKQ--EAYVKLEPLGEGSYATVYKGFSKLTYQRVALKEIRLQ 239
            .||::.:.......||.|| ..:|::  |.:..||.:|||:|..|||...:.|.:.||||::||:
Mosquito  1096 ILNRRHSRNMTAPMSASGG-KDWGERCVEVFDMLEQIGEGTYGQVYKAKDQQTNELVALKKVRLE 1159

  Fly   240 -EEEGAPFTAIREASLLKELKHSNIVTLHDIV-HTRETLTF---------VFEYVNTDLSQYMEK 293
             |:||.|.||:||..:|::|.|.|||.|.:|| ..::.|.|         ||||::.||...:|.
Mosquito  1160 HEKEGFPITAVREIKILRQLNHQNIVNLREIVTDKQDALEFRKDKGSFYLVFEYMDHDLMGLLES 1224

  Fly   294 HPGGLDHRNVRLFLFQLLRGLSYCHKRRVLHRDVKPQNLLISDCGELKLADFGLARAKSVPS--H 356
            .....:.:|....:.|||.||:||||:..||||:|..|:|:::.||:|||||||||..:..:  .
Mosquito  1225 GMVDFNEQNNASIMRQLLDGLNYCHKKNFLHRDIKCSNILMNNRGEVKLADFGLARLYNADNRER 1289

  Fly   357 TYSHEVVTLWYRPPDVLLGSTEYSTSLDMWGVGCIFVEMVTGMPTFPGIRDTYDQLDKIFKLLGT 421
            .|:::|:|||||||::|||...|..::|:|..|||..|:....|.|...::. .||:.|.:|.||
Mosquito  1290 PYTNKVITLWYRPPELLLGEERYGPAIDVWSCGCILGELFLKKPLFQANQEP-AQLEMISRLCGT 1353

  Fly   422 PTEDTWPGVTHFPGYKPHKLGFYRPRKLGHNF-----PRLYDIIEGETIANGFLQLNPEQRLGAD 481
            ||...||.|...|.:...|......|||..:|     |.| |:::      ..|.|:|::|:.|:
Mosquito  1354 PTPAVWPNVIKLPLFHTLKSKKQYRRKLREDFVFMPMPSL-DLLD------SMLVLDPDRRITAE 1411

  Fly   482 DALQHPYFAQ-LPKKL 496
            |||:..:... :|::|
Mosquito  1412 DALKSNWLKNVIPEQL 1427

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eip63E	NP_001261373.1	STKc_PCTAIRE_like	204..489	CDD:270835	119/302 (39%)
Cdk12	XP_061498912.1	None