Protein Alignment Eip63E and Cdk4

DIOPT Version :10

• Sequence 1: NP_001261373.1
• Gene: Eip63E / 38433
• FlyBaseID: FBgn0005640
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_034000.1
• Gene: Cdk4 / 12567
• MGIID: 88357
• Length: 303
• Species: Mus musculus
• Alignment Length: 313
• Identity: 123/313 - (39%)
• Similarity: 166/313 - (53%)
• Gaps: 48/313 - (15%)

  Fly   204 AYVKLEP---LGEGSYATVYKGFSKLTYQRVALKEIRLQE----EEGAPFTAIREASLLKEL--- 258
            |..:.||   :|.|:|.||||.....:...||||.:|:..    ..|.|.:.:||.:||:.|
Mouse     2 AATRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGAAGGGLPVSTVREVALLRRLEAF 66

  Fly   259 KHSNIVTLHDIVHTRET-----LTFVFEYVNTDLSQYMEK-HPGGLDHRNVRLFLFQLLRGLSYC 317
            :|.|:|.|.|:..|..|     :|.|||:::.||..|::| .|.||....::..:.|.|.||.:.
Mouse    67 EHPNVVRLMDVCATSRTDRDIKVTLVFEHIDQDLRTYLDKAPPPGLPVETIKDLMRQFLSGLDFL 131

  Fly   318 HKRRVLHRDVKPQNLLISDCGELKLADFGLARAKSVPSHTYSHE------VVTLWYRPPDVLLGS 376
            |...::|||:||:|:|::..|.:|||||||||       .||::      |||||||.|:|||.|
Mouse   132 HANCIVHRDLKPENILVTSNGTVKLADFGLAR-------IYSYQMALTPVVVTLWYRAPEVLLQS 189

  Fly   377 TEYSTSLDMWGVGCIFVEMVTGMPTFPGIRDTYDQLDKIFKLLGTPTEDTWPGVTHFPGYKPHKL 441
            | |:|.:|||.|||||.||....|.|.|..:. |||.|||.|:|.|.||.||.....|      .
Mouse   190 T-YATPVDMWSVGCIFAEMFRRKPLFCGNSEA-DQLGKIFDLIGLPPEDDWPREVSLP------R 246

  Fly   442 GFYRPRKLGHNFPRLYDIIEGETIANG------FLQLNPEQRLGADDALQHPY 488
            |.:.||.     ||....:..|...:|      .|..||.:|:.|..||||.|
Mouse   247 GAFAPRG-----PRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSY 294

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eip63E	NP_001261373.1	STKc_PCTAIRE_like	204..489	CDD:270835	123/313 (39%)
Cdk4	NP_034000.1	STKc_CDK4	5..295	CDD:143368	122/310 (39%)
		Required for binding D-type cyclins. /evidence=ECO:0000250	50..56		1/5 (20%)