Protein Alignment Eip63E and CDK6

DIOPT Version :9

• Sequence 1: NP_001261373.1
• Gene: Eip63E / 38433
• FlyBaseID: FBgn0005640
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_001138778.1
• Gene: CDK6 / 1021
• HGNCID: 1777
• Length: 326
• Species: Homo sapiens
• Alignment Length: 310
• Identity: 129/310 - (41%)
• Similarity: 175/310 - (56%)
• Gaps: 33/310 - (10%)

  Fly   203 EAYVKLEPLGEGSYATVYKGFSKLTYQR-VALKEIRLQE-EEGAPFTAIREASLLKEL---KHSN 262
            :.|..:..:|||:|..|:|........| ||||.:|:|. |||.|.:.|||.::|:.|   :|.|
Human    11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPN 75

  Fly   263 IVTLHDIVHT----RET-LTFVFEYVNTDLSQYMEKHP-GGLDHRNVRLFLFQLLRGLSYCHKRR 321
            :|.|.|:...    ||| ||.|||:|:.||:.|::|.| .|:....::..:|||||||.:.|..|
Human    76 VVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHR 140

  Fly   322 VLHRDVKPQNLLISDCGELKLADFGLARAKSVPSHTYSHE------VVTLWYRPPDVLLGSTEYS 380
            |:|||:||||:|::..|::|||||||||       .||.:      |||||||.|:|||.|: |:
Human   141 VVHRDLKPQNILVTSSGQIKLADFGLAR-------IYSFQMALTSVVVTLWYRAPEVLLQSS-YA 197

  Fly   381 TSLDMWGVGCIFVEMVTGMPTFPGIRDTYDQLDKIFKLLGTPTEDTWPGVTHFPGYKPHKLGFYR 445
            |.:|:|.|||||.||....|.|.|..|. |||.||..::|.|.|:.||.....|....|......
Human   198 TPVDLWSVGCIFAEMFRRKPLFRGSSDV-DQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQP 261

  Fly   446 PRKLGHNFPRLYDIIE-GETIANGFLQLNPEQRLGADDALQHPYFAQLPK 494
            ..|.      :.||.| |:.:....|..||.:|:.|..||.||||..|.:
Human   262 IEKF------VTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLER 305

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eip63E	NP_001261373.1	PLN00009	203..492	CDD:177649	128/306 (42%)
		STKc_PCTAIRE_like	204..489	CDD:270835	126/302 (42%)
CDK6	NP_001138778.1	STKc_CDK6	11..300	CDD:270846	126/303 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0594
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810