Protein Alignment Eip63E and CDK4

DIOPT Version :10

• Sequence 1: NP_001261373.1
• Gene: Eip63E / 38433
• FlyBaseID: FBgn0005640
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_000066.1
• Gene: CDK4 / 1019
• HGNCID: 1773
• Length: 303
• Species: Homo sapiens
• Alignment Length: 304
• Identity: 122/304 - (40%)
• Similarity: 166/304 - (54%)
• Gaps: 35/304 - (11%)

  Fly   205 YVKLEPLGEGSYATVYKGFSKLTYQRVALKEIRLQEEEGA----PFTAIREASLLKEL---KHSN 262
            |..:..:|.|:|.||||.....:...||||.:|:....|.    |.:.:||.:||:.|   :|.|
Human     6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70

  Fly   263 IVTLHDIVHTRET-----LTFVFEYVNTDLSQYMEK-HPGGLDHRNVRLFLFQLLRGLSYCHKRR 321
            :|.|.|:..|..|     :|.|||:|:.||..|::| .|.||....::..:.|.||||.:.|...
Human    71 VVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANC 135

  Fly   322 VLHRDVKPQNLLISDCGELKLADFGLARAKSVPSHTYSHE------VVTLWYRPPDVLLGSTEYS 380
            ::|||:||:|:|::..|.:|||||||||       .||::      |||||||.|:|||.|| |:
Human   136 IVHRDLKPENILVTSGGTVKLADFGLAR-------IYSYQMALTPVVVTLWYRAPEVLLQST-YA 192

  Fly   381 TSLDMWGVGCIFVEMVTGMPTFPGIRDTYDQLDKIFKLLGTPTEDTWPGVTHFP-GYKPHKLGFY 444
            |.:|||.|||||.||....|.|.|..:. |||.|||.|:|.|.||.||.....| |..|.:
Human   193 TPVDMWSVGCIFAEMFRRKPLFCGNSEA-DQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPR---- 252

  Fly   445 RPRKLGHNFPRLYDIIEGETIANGFLQLNPEQRLGADDALQHPY 488
            .||.:....|.:.:  .|..:....|..||.:|:.|..||||.|
Human   253 GPRPVQSVVPEMEE--SGAQLLLEMLTFNPHKRISAFRALQHSY 294

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eip63E	NP_001261373.1	STKc_PCTAIRE_like	204..489	CDD:270835	122/304 (40%)
CDK4	NP_000066.1	Protein Kinases, catalytic domain	5..295	CDD:473864	122/304 (40%)
		Required for binding D-type cyclins	50..56		1/5 (20%)