DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eip63E and cdk17

DIOPT Version :9

Sequence 1:	NP_001261373.1	Gene:	Eip63E / 38433	FlyBaseID:	FBgn0005640	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	XP_012813857.1	Gene:	cdk17 / 100101773	XenbaseID:	XB-GENE-920552	Length:	523	Species:	Xenopus tropicalis

Alignment Length:	538	Identity:	237/538 - (44%)
Similarity:	315/538 - (58%)	Gaps:	79/538 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LQKLKKRLSHSF-GRLTISR-----------------------EDGDESTHHHHHH--HHHRGGH 68
            ::|.|:|||.:. |..||..                       ::|...|.|..|.  |.:.|..
Frog     1 MKKFKRRLSLTLRGSQTIDESLSELAEQMTIEENSSKDNEPIVKNGRPPTSHSMHSFLHQYTGSF 65

  Fly    69 ------------GGHHNHGNKVPYNGYNSEEYLDRLEPNGNIPADKTNCRYGAQESAKNDNNKPQ 121
                        ||.......:|.||    ..||.:..|..:.:|        .||.:.......
Frog    66 KKPPLRRPHSVIGGSLGSFMAMPRNG----SRLDIVHENLKMGSD--------GESDQASGTSSD 118

  Fly   122 DWRSTDSTDHHDRVQRQLSVSSDSKLLD--EDIR------EEMKYHSHVVMRPKKPPRPKSEVFL 178
            :.:|.......:|:.|::|:...:|.|.  .|||      |:::.:|        ||      |.
Frog   119 EVQSPTGVCLRNRIHRRISMEDLNKRLSLPADIRIPDGYLEKLQINS--------PP------FD 169

  Fly   179 NKQETHPRRKRFSAFGGDSPFGKQEAYVKLEPLGEGSYATVYKGFSKLTYQRVALKEIRLQEEEG 243
            .......||...|..|    |||.|.|||||.||||:||||:||.||||...||||||||:.|||
Frog   170 QPMSRRSRRASLSEIG----FGKMETYVKLEKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEG 230

  Fly   244 APFTAIREASLLKELKHSNIVTLHDIVHTRETLTFVFEYVNTDLSQYMEKHPGGLDHRNVRLFLF 308
            ||.|||||.||||:|||:|||||||||||.::||.||||::.||.|||:.....:...||::||:
Frog   231 APCTAIREVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSIHNVKIFLY 295

  Fly   309 QLLRGLSYCHKRRVLHRDVKPQNLLISDCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVL 373
            |:||||:|||||:|||||:|||||||::.|||||||||||||||||:.|||:|||||||||||||
Frog   296 QILRGLAYCHKRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360

  Fly   374 LGSTEYSTSLDMWGVGCIFVEMVTGMPTFPGIRDTYDQLDKIFKLLGTPTEDTWPGVTHFPGYKP 438
            |||:||||.:|||||||||.||.:|.|.||| ....|:|..||:|||||.|:||||::....::.
Frog   361 LGSSEYSTQIDMWGVGCIFFEMASGRPLFPG-STVEDELHLIFRLLGTPAEETWPGISSNDEFRN 424

  Fly   439 HKLGFYRPRKLGHNFPRLYDIIEGETIANGFLQLNPEQRLGADDALQHPYFAQLPKKLYELPDET 503
            :....|:|:.:.::.|||..  ||..:...|||...::|:.|:||::|.||..|..|::.||:..
Frog   425 YNFPKYKPQPVINHAPRLDS--EGIELLTRFLQYESKKRISAEDAMKHAYFRSLGTKIHSLPENI 487

  Fly   504 SIFTVEGVQLYTEPNRQN 521
            |||:::.:||..:|..:|
Frog   488 SIFSLKDIQLQKDPGFRN 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eip63E	NP_001261373.1	PLN00009	203..492	CDD:177649	180/288 (63%)
Eip63E	NP_001261373.1	STKc_PCTAIRE_like	204..489	CDD:270835	177/284 (62%)
cdk17	XP_012813857.1	STKc_PCTAIRE2	185..493	CDD:143377	191/314 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1010560at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3201
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.040