DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42324 and TJAP1

DIOPT Version :9

Sequence 1:	NP_647819.3	Gene:	CG42324 / 38430	FlyBaseID:	FBgn0259224	Length:	1037	Species:	Drosophila melanogaster
Sequence 2:	NP_001139488.1	Gene:	TJAP1 / 93643	HGNCID:	17949	Length:	557	Species:	Homo sapiens

Alignment Length:	628	Identity:	129/628 - (20%)
Similarity:	214/628 - (34%)	Gaps:	218/628 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 EIEQLQQALIEKQTQLYALESACLRETE-----RQVEL---EDSVIAWQDKYDRLYESHKRVQKV 105
            |.|:|::.|.....:..|||    ||.|     .::||   .:.:..::||:.||..|:...|:.
Human    48 ENEELRRRLASATRRTEALE----RELEIGQDCLELELGQSREELDKFKDKFRRLQNSYTASQRT 108

  Fly   106 NQSLEDKMLKL----------VDRNAGERAQLTSDVATLSVRLAQANFNIAKLQREIERYKADIS 160
            ||.||||:..|          :.:...:|..|..::..|:.:|..|...|.||:...|||:.|.:
Human   109 NQELEDKLHTLASLSHSWIFAIKKAEMDRKTLDWEIVELTNKLLDAKNTINKLEELNERYRLDCN 173

  Fly   161 LAIQLLQCKPDSFVSQKVSSLPIDIQSKVSAYMRLETNSHSDSECSNSGVGVATTASYKVLPASD 225
            ||:|||:|....|.:.|.:.||.::|..|..::      ||..|.                 ||.
Human   174 LAVQLLKCNKSHFRNHKFADLPCELQDMVRKHL------HSGQEA-----------------ASP 215

  Fly   226 SPPPSACPFPPTAMVYSMRGIGRYAANGNTTTNPQQQSNQPTNNNTSNNKDTLNNNNVNNNSNNN 290
            .|.||   ..|.|:|                         ||
Human   216 GPAPS---LAPGAVV-------------------------PT----------------------- 229

  Fly   291 CNNQTNTSISNNNHATNPDMISPTIMAKFLE--DELKANEVKHCDTCQCSKQDLQVLADVSRSYS 353
                                   :::|:.||  :.|..|..:.....:...:|:.|..|:|....
Human   230 -----------------------SVIARVLEKPESLLLNSAQSGSAGRPLAEDVFVHVDMSEGVP 271

  Fly   354 VSTQTP--------------HQLQLQGSGLNEPLTQLCLRCHSNLNSPSRTNSPYLM----KMVK 400
            ....:|              |.|   |:....|..:|.|.....||.....:.|:.:    ::::
Human   272 GDPASPPAPGSPTPQPNGECHSL---GTARGSPEEELPLPAFEKLNPYPTPSPPHPLYPGRRVIE 333

  Fly   401 SSDSVISETKSSVSDLNDMDKLFIPAKKDDLMVNPILGHHRLCERTAISGQNTEYGNGKLTTSTM 465
            .|:                ||:.||.       |..|.:.....|.|||....|.|:.:...|.:
Human   334 FSE----------------DKVRIPR-------NSPLPNCTYATRQAISLSLVEEGSERARPSPV 375

  Fly   466 MYPTTHLGAYAAEKY------------LLETSNLGQLRNGYQRRFLDG-------------GGTA 505
              |:|...|.|:..:            ....|:...|...:||.|:|.             |..|
Human   376 --PSTPASAQASPHHQPSPAPLTLSAPASSASSEEDLLVSWQRAFVDRTPPPAAVAQRTAFGRDA 438

  Fly   506 LQLLNKYEAGAVGVVHGDLE-DESSKPLLAGVSQPSLLEAEQAPPQQS--VVPAKLEDVC---EP 564
            |..|.::.|      |...: ||             :::|..|.|::|  ::|.:.:...   |.
Human   439 LPELQRHFA------HSPADRDE-------------VVQAPSARPEESELLLPTEPDSGFPREEE 484

  Fly   565 QPSKPVAPVAPPGSTAPAVPSGTQLKSTNSGSVQSLWSNKTSS 607
            :.:.|::|.....|..| :..||:.....|.:....|...:||
Human   485 ELNLPISPEEERQSLLP-INRGTEEGPGTSHTEGRAWPLPSSS 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42324	NP_647819.3	DUF4200	49..156	CDD:290574	35/124 (28%)
TJAP1	NP_001139488.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37
		SMC_N	<17..>163	CDD:330553	33/118 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	266..303		6/39 (15%)
		Pilt	284..556	CDD:317806	57/291 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	309..328		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..409		8/46 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	439..557		22/108 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004208
OrthoInspector	1	1.000	-	-		otm42209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR28664
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5758
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.130