DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42324 and tjap1

DIOPT Version :9

Sequence 1:	NP_647819.3	Gene:	CG42324 / 38430	FlyBaseID:	FBgn0259224	Length:	1037	Species:	Drosophila melanogaster
Sequence 2:	XP_021336605.1	Gene:	tjap1 / 566060	ZFINID:	ZDB-GENE-081107-47	Length:	1099	Species:	Danio rerio

Alignment Length:	766	Identity:	140/766 - (18%)
Similarity:	239/766 - (31%)	Gaps:	291/766 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 AGNPK----AAEISTAKSAISTATAAPAIAATPLATSAPAAAEI-----EQLQQALIEKQTQLYA 66
            :|.||    ...:.:.|:::|..||...::....:.|.....:|     |.|::.|.:...::.|
Zfish   432 SGLPKGEIPTIRVESEKTSLSQVTAFTILSQIKESLSDADRIKILQQQNEDLRRRLSQTTHKMEA 496

  Fly    67 LESACLRETER---QVEL---EDSVIAWQDKYDRLYESHKRVQKVNQSLEDKM------------ 113
            :|:..  ||.|   |.||   .|.:...:||:.||..|:...|:.||.||:|:
Zfish   497 METEF--ETSRHYMQAELGRTRDDLEKMRDKFRRLQNSYTASQRANQDLEEKLHALAAISQTWVY 559

  Fly   114 -LKLVDRNAGERAQLTSDVATLSVRLAQANFNIAKLQREIERYKADISLAIQLLQCKPDSFVSQK 177
             |:.|:|   ::..:..::..|:.:|..|...|.||:...|||:.|.:||:|||:|....|.:.|
Zfish   560 ALRKVER---DKKTMDQEIVELTNKLVDAKNTIDKLEELNERYRQDCNLAVQLLKCNKSHFRNHK 621

  Fly   178 VSSLPIDIQSKVSAYMR----------------------------------------LETNS--- 199
            .:.||.::|..|:.:|:                                        |..||
Zfish   622 FADLPYELQDMVNKHMKSSLPNKTQGAQAQDPDTLSLTPADVVPTSVIARVLEKPEPLVLNSAQS 686

  Fly   200 -----------------------------------------------HSDSECSNSGVGVATTAS 217
                                                           |.:..|.:.|.....|..
Zfish   687 SSSAGRPVAEDVFVHVDMTGPQDDDGGRENGGPVPARPPAVADTDQQHVNGMCRSQGSLDGPTGD 751

  Fly   218 YKVLPASDSPPPSACPFPPTAMVYSMRGIGRYAANGNTTTNPQQQSNQPTNNNTSNNKDTLNNNN 282
            ....|:.:...|...|.||..: |..|.:..::::...    :...|.|..|.|...:..::.:.
Zfish   752 DGAAPSFEKLNPYPTPSPPNPL-YPGRKVIEFSSDDKV----KIPKNSPLPNCTYATRQAISLSL 811

  Fly   283 VNNN----------------SNNNCNNQTNTSISNN--NHATNPDMISPTIMAKFLEDELKANEV 329
            |.|.                |:....:.|::|....  :|...|..:..|
Zfish   812 VQNEEEAAERQRTVPNSPAISDGGWRSGTSSSSGGGIASHQRTPPQMDAT--------------- 861

  Fly   330 KHCDTCQCSKQDLQVLADVSRSYSVSTQTPHQLQLQGSGLNEPLTQLCLRCHSNLNSPSRTNSPY 394
               ||          |:..|..:|...|.|......||...:.|              :.....:
Zfish   862 ---DT----------LSSHSSPFSSPPQPPSAFASSGSSEEDLL--------------ASWQRMF 899

  Fly   395 LMKMVKSSD-SVISETKSSVSDLNDMDKLFIPAKKDDLMVNPILGHHRLCERTAISGQNTEYGNG 458
            :.||..||| |:::.|..|...:.|:.:                .|:   .::.:......|.:|
Zfish   900 VEKMAPSSDGSLVNRTSFSSETVKDLQR----------------SHN---GKSGVGALRGAYSDG 945

  Fly   459 KLTTSTMMYPTTHLGAYAAEKYL-LETSNLGQLRNGYQRRFLDGGGTALQLLNKYEAGAVGVVHG 522
            :..:|...:..:.      |..| .:||::..||                 ..|.:.|      |
Zfish   946 EEGSSAQSWTASR------ESSLDTDTSSMADLR-----------------AKKTQYG------G 981

  Fly   523 DLEDESSKPLLA--------GVSQPSLLEAEQAP-------------------------PQQ--- 551
            |...|..:.||.        |.|..:::..|.:|                         ||.
Zfish   982 DFSHEEGEHLLMALDPLDNDGASGDTMVTIESSPASAKRQEFAEDVGSAGSSAEERDVLPQDFPV 1046

  Fly   552 --SVVPAKLEDVCEPQPSKPVAPVAPPGSTAPAVPSGTQLKSTNSGSVQSL 600
              |.|.:.|||..:..|.        .||:.|       |||.....|..|
Zfish  1047 IGSRVLSSLEDYADKPPR--------TGSSRP-------LKSPKRMGVHHL 1082

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42324	NP_647819.3	DUF4200	49..156	CDD:290574	35/130 (27%)
tjap1	XP_021336605.1	Lebercilin	472..611	CDD:317931	41/143 (29%)
tjap1	XP_021336605.1	Pilt	724..1098	CDD:317806	79/469 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004208
OrthoInspector	1	1.000	-	-		otm25009
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR28664
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5758
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.130