Protein Alignment IPO5 and Apl

DIOPT Version :10

• Sequence 1: XP_005254109.1
• Gene: IPO5 / 3843
• HGNCID: 6402
• Length: 1115
• Species: Homo sapiens
• Sequence 2: NP_730182.1
• Gene: Apl / 59216
• FlyBaseID: FBgn0042178
• Length: 1080
• Species: Drosophila melanogaster
• Alignment Length: 1157
• Identity: 250/1157 - (21%)
• Similarity: 486/1157 - (42%)
• Gaps: 199/1157 - (17%)

Human    49 ETYENIPGQSKITFLLQAIRNTTAAEEARQMAAVLLRRLLSSAFDEVYPALPSDVQTAIKSELLM 113
            :.|||   ...:..|.|.:.:....:| ||:|||||:|.:...  ..:..:|::.|.||||.:|.
  Fly    29 KAYEN---PDSLLVLTQIVMSDRPVQE-RQVAAVLLKRRVKKL--RHWQLVPAEHQAAIKSNMLQ 87

Human   114 IIQMETQSSMRKKVCDIAAELARNLIDEDGNNQWPEG-LKFLFDSVSSQNVGLREAALHIFWNFP 177
            ::....:.:::..|..|...|.|:  :|...|.|.|. |||:::..||.:....|....||.:..
  Fly    88 VLIAVKEKTVKGTVAFIIGSLVRH--EEGEQNSWREEILKFIYERCSSPDPIESERGSSIFSSLM 150

Human   178 GIFGNQQQHYLDVIKRMLVQCMQDQEHPSIRTLSARATAAFILANEHNVALFKHFADLLPGFLQA 242
            ....:|...:.|.:..:|...:          ::|.|.........||:.....|  ||| |:
  Fly   151 DAAPDQFSDHTDTMFPLLAGIL----------VTAEANGNMATPTVHNMLTGSCF--LLP-FV-- 200

Human   243 VNDSCYQNDDS--------VLKSLV---------------EIADTVPKYLRPH-LEATLQLSLKL 283
               |.:.|.:.        :||:|.               :|.|::.::: || |...::|.|:.
  Fly   201 ---SGHSNAEQIVVKAVPLILKALAAFVEKGYSIEFMGAFDIIDSMAEHV-PHLLTGNVKLLLEF 261

Human   284 CGDTSLNNMQRQLALEVIVTLSETAAAMLRKHTNIVAQTIPQMLAMMV------DLEE-DEDWAN 341
            |...: .|.|...::.|.|.....:...|:|...:..:.:...|:::.      |||| |:|:.:
  Fly   262 CLMIA-RNKQFDASIRVQVLTFVGSLVRLKKKIIMKQKLLQPTLSVLFEVICQDDLEEGDDDYFS 325

Human   342 ADELEDDDFDSNAVAGESALDRMACGLGGKLVLPMIKEHIMQMLQNPDWKYRHAGLMALSAIGEG 406
            ::.|..   .|||.|  ..||.||..:.....:|.:.:.:...||:|:...|.:..:.:..|.||
  Fly   326 SESLSS---PSNAAA--QTLDLMALHMVPDKFIPPLLDLLEPALQSPEPVLRRSSFICMGVIAEG 385

Human   407 CHQQM-EGILNEIVNFVLLFLQDPHPRVRYAACNAVGQMA-------TDFAPGFQKKFHEKVIAA 463
            |.:.: :..|..::|.:...:.|....||.||..|:||.:       ..|||.......:.:...
  Fly   386 CSEAIGKKYLEVMLNIIKAGVLDSVMFVRTAAFFALGQFSEFLQPTICKFAPQILPVLFDYLNQL 450

Human   464 LLQTMEDQGNQRVQAHAAAALINFTEDCPKSLLIPYLDNLVKHLHSIMVLKLQELIQKGTKLVLE 528
            :|:....:.:.:.......||..|.|:..:. ::|||..|:..|..:|.       .:.:..:.|
  Fly   451 VLELKVGEPDSKHMDRMFYALETFCENLDED-IVPYLPTLMDRLFGVME-------PQNSNQMRE 507

Human   529 QVVTSIASVADTAEEKFVPYYDLFMPSLKHIVENAVQKELRLLRGKTIECISLIGLAVGKEKFMQ 593
            ..:::||:|:..|:|..:||:...|..|:..:.....||:...|.:.|:.::.:...:||:..:.
  Fly   508 MALSAIAAVSAAAKENLMPYFPRIMTVLQGCLVKDCPKEMYSQRIQAIDTLAALCRELGKDNIIP 572

Human   594 DASDVMQLLLKTQTDFNDMED--DDPQISYMISAWARMCKI-------LGKEFQQYLPVVMGPLM 649
            .|.|.|...|..      :||  |||:  |..|.:..|..:       :...|.:::..:|..::
  Fly   573 LADDTMNFCLMM------LEDGPDDPE--YRRSIYNLMSSLSSVVNESMASVFPKFIDRIMESVI 629

Human   650 KTASIKPEV--------ALLDTQ----DMENMSDDDGWEFVNLGDQQSFGIKTAGLEEKSTACQM 702
            .:..:.|.|        ||:|..    |:|:..|:|        ||.::.::...:.||..|...
  Fly   630 FSEDMVPNVSDNADDDLALVDAPDIEIDLEHTDDED--------DQDAYPVENDYIVEKEEAILS 686

Human   703 LVCYAKELKEGFVEYTEQVVKLMVPLLKFYFHDGVRVAAAESMPLLLECARVRGPEYLTQMWHFM 767
            |..:|......|..|.:...:.:..::.....| ||:|..:|:     |:      ::|.: |.:
  Fly   687 LKEFATHTGAAFAPYLQSAFENVYKMIDHPQGD-VRMACIDSI-----CS------FITAL-HKL 738

Human   768 CDALIKAIGTEPDSDVLSEIMHS------FAKCIEVMGD-----GCLNN-EHFEELGGILKAKLE 820
            .||.......|......:.||.:      ..:.::|:.|     ..:|: ||.|.:.|.::
  Fly   739 DDAAGLKRACEIAIPKFAHIMRTDDQVAVVLRMLDVLYDVFKYVPAINSQEHAELIFGCIR---- 799

Human   821 EHFKNQELRQVKRQDEDYDEQVEESLQDEDDNDVYILTKVSDIL--------HSIFSSYKEKVLP 877
            :.|.|:...|...:....|::..|    |.:||..:....:::.        ..:||.|..::..
  Fly   800 DIFTNKMACQFNEESGGGDDECSE----ESENDEMLFENAANLFPMFGLTLQPELFSLYFGRLYH 860

Human   878 WFEQLLPLIVNLICPHRPWPDRQWGLCIFDDVIEHCSPASFKYAEYF--LRPMLQYVC---DNSP 937
            ::.|.|..:     ..|..|:::  ..|:..:.:.|.......|.||  |||:  ::.   |:..
  Fly   861 FYIQRLAKV-----KERDLPEQR--AYIYGALADCCKALKGCCATYFDALRPI--FIAGSRDSDA 916

Human   938 EVRQAAAYGLGVMAQYGGDNYRPFCTEALPLLVRVIQSADSKTKENVNAT-ENCISAVGKIMKFK 1001
            :.||.:.:.||.:..:..:  :.|  |:.|.:::.:  :::..:|:|.|. :|...||.:::...
  Fly   917 KARQNSYFALGEIVFHSEE--KSF--ESYPTILQAL--SEAIVRESVPAAMDNICGAVARLIVTN 975

Human  1002 PDCVNVEEVLPHWLSWLPLHEDKEEAVQTFNYLCDLIESNHPIV---LGPN-NTNLPKIFSIIAE 1062
            ||.|.:.:|||.||:.|||.:|..|.        |:|:....::   ..|: ..:|.:|.:|..|
  Fly   976 PDSVPLGQVLPVWLNHLPLKDDTVEN--------DVIQKAFRVLYLKARPSIEAHLEQILAITIE 1032

Human  1063 GEMHEAIKHEDPCAKRLANVVRQVQTSGGLWTEC---IAQLSPEQQAAIQEL 1111
            .    :.|.:.|..:...:.|..::.....:.|.   ::.::||....:|.|
  Fly  1033 A----SYKRQMPDVETTESAVALIKEIRANYPELFSKVSNMNPEVFNYVQAL 1080

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IPO5	XP_005254109.1	KAP95	31..>652	CDD:227540	147/651 (23%)
		HEAT repeat	111..133	CDD:293787	3/21 (14%)
		HEAT repeat	150..178	CDD:293787	8/28 (29%)
		HEAT repeat	195..217	CDD:293787	3/21 (14%)
		HEAT repeat	235..263	CDD:293787	10/50 (20%)
		HEAT repeat	275..316	CDD:293787	9/40 (23%)
		Importin_rep_4	286..375	CDD:408579	22/95 (23%)
		HEAT repeat	373..405	CDD:293787	6/31 (19%)
		HEAT repeat	417..447	CDD:293787	9/36 (25%)
		HEAT repeat	459..486	CDD:293787	3/26 (12%)
		HEAT repeat	500..537	CDD:293787	7/36 (19%)
		HEAT repeat	549..582	CDD:293787	6/32 (19%)
		Importin_rep_6	783..892	CDD:465881	22/128 (17%)
		HEAT repeat	883..908	CDD:293787	4/24 (17%)
		HEAT repeat	921..954	CDD:293787	11/37 (30%)
		HEAT_EZ	937..984	CDD:463906	8/46 (17%)
		HEAT repeat	964..1000	CDD:293787	8/36 (22%)
		HEAT repeat	1009..1033	CDD:293787	10/23 (43%)
		Importin_rep_5	1023..1069	CDD:465877	9/49 (18%)
Apl	NP_730182.1	IBN_N	29..90	CDD:197981	21/66 (32%)
		KAP95	<304..703	CDD:227540	97/427 (23%)
		HEAT repeat	356..384	CDD:293787	5/27 (19%)
		HEAT repeat	397..427	CDD:293787	9/29 (31%)
		HEAT repeat	438..473	CDD:293787	3/34 (9%)