Protein Alignment IPO5 and Arts

DIOPT Version :10

• Sequence 1: XP_005254109.1
• Gene: IPO5 / 3843
• HGNCID: 6402
• Length: 1115
• Species: Homo sapiens
• Sequence 2: NP_001261957.1
• Gene: Arts / 59215
• FlyBaseID: FBgn0042177
• Length: 1080
• Species: Drosophila melanogaster
• Alignment Length: 1135
• Identity: 241/1135 - (21%)
• Similarity: 487/1135 - (42%)
• Gaps: 155/1135 - (13%)

Human    49 ETYENIPGQSKITFLLQAIRNTTAAEEARQMAAVLLRRLLSSAFDEVYPALPSDVQTAIKSELLM 113
            :.|||   ...:..|.|.:.:....:| ||:|||||:|.:...  ..:..:|::.|.||||.:|.
  Fly    29 KAYEN---PDSLLVLTQIVMSDRPVQE-RQVAAVLLKRRVKKL--RHWQLVPAEHQAAIKSNMLQ 87

Human   114 IIQMETQSSMRKKVCDIAAELARNLIDEDGNNQWPEG-LKFLFDSVSSQNVGLREAALHIFWNFP 177
            ::....:.:::..|..|...|.|:  :||..|.|.|. |||:::..||.:....|....||.:..
  Fly    88 VLIAVKEKTVKGTVAFIIGSLVRH--EEDKQNSWREEILKFIYERCSSPDPIESERGSSIFSSLM 150

Human   178 GIFGNQQQHYLDVIKRMLVQCMQDQE------HPSIRTLSARATAAFILANEHNVALFKHFADLL 236
            ....:|..::.|.|..:|...:...|      .|::..:.|.........:.|:.| .:.....:
  Fly   151 DAAPDQFSNHTDTIFPLLAGILVTAEANGNMATPTVHNMLAGTCVLLPFISGHSDA-EQIMVKAV 214

Human   237 PGFLQAVNDSCYQNDDSVLKSLVEIADTVPKYLRPH-LEATLQLSLKLCGDTSLNNMQRQLALEV 300
            |..|:|:.....:.:.:......:|.|::.:|: || |...::|.|:.|...: .|.|...::.|
  Fly   215 PLILKALAAFAEKGNSNEFMGAFDIIDSMAEYV-PHLLTGNVKLLLEFCLMIA-RNKQFDASIRV 277

Human   301 IVTLSETAAAMLRKHTNIVAQTIPQMLAMMV------DLEE-DEDWANADELEDDDFDSNAVAGE 358
            .|.....:...|:|...:..:.:...|:::.      ||:| |:|:.:::.|..   .|||.|
  Fly   278 QVLTFVGSLVRLKKKIIMKQKLLQPTLSVLFEVICQDDLKEGDDDYFSSESLNS---PSNAAA-- 337

Human   359 SALDRMACGLGGKLVLPMIKEHIMQMLQNPDWKYRHAGLMALSAIGEGCHQQM-EGILNEIVNFV 422
            ..||.||..:.....:|.:.:.:...||:|:...|.:..:.:..|.|||.:.: :..|..::|.:
  Fly   338 QTLDLMALHMVPDKFIPPLLDLLEPALQSPEPVLRRSSFICMGVIAEGCSEAIGKKYLEVMLNII 402

Human   423 LLFLQDPHPRVRYAACNAVGQMA-------TDFAPGFQKKFHEKVIAALLQTMEDQGNQRVQAHA 480
            ...:.|....||.||..|:||.:       ..|||.......:.:...:|:....:.:.:.....
  Fly   403 KAGVLDSVMFVRTAAFFALGQFSEFLQPTICKFAPQILPVLFDYLNQLVLELKVGEPDSKHMDRM 467

Human   481 AAALINFTEDCPKSLLIPYLDNLVKHLHSIMVLKLQELIQKGTKLVLEQVVTSIASVADTAEEKF 545
            ..||..|.|:..:. ::|||..|:..|..:|.       .:.:..:.|..:::||:|:..|:|..
  Fly   468 FYALETFCENLDED-IVPYLPTLMDRLFGVME-------PQNSNQMREMALSAIAAVSAAAKENL 524

Human   546 VPYYDLFMPSLKHIVENAVQKELRLLRGKTIECISLIGLAVGKEKFMQDASDVMQLLLKTQTDFN 610
            :||:...|..|:..:.....||:...|.:.|:.::.:...:||:..:..|.:.|...|..
  Fly   525 MPYFPRIMTVLQGCLVKDCPKEMYSQRIQAIDTLAALCRELGKDNIIPLADETMNFCLMM----- 584

Human   611 DMED--DDPQI-----SYMISAWARMCKILGKEFQQYLPVVMGPLMKTASIKPEV--------AL 660
             :||  |||:.     :.|.|..:.:.:.:...|.:::..:|..::.:..:.|.|        ||
  Fly   585 -LEDGPDDPEFRRSIYNLMSSLSSVVNESMASVFPKFIDRIMESVISSEDMVPNVSDNAEDDLAL 648

Human   661 LDTQ----DMENMSDDDGWEFVNLGDQQSFGIKTAGLEEKSTACQMLVCYAKELKEGFVEYTEQV 721
            :|..    |:|:..|:|        ||.::..:...:.||..|...|..:|......|..|.:..
  Fly   649 VDAPDIEIDLEHTDDED--------DQDAYLGENDYIVEKEEAILSLKEFATHTGAAFAPYLQSA 705

Human   722 VKLMVPLLKFYFHDGVRVAAAESMPLLLECARVRGPEYLTQMWHFMCDALIKAIGTEPDSDVLSE 786
            .:.:..::.....| ||:|..:|:     |:      ::|.: |.:.||.......|......:.
  Fly   706 FENVYKMIDHPQGD-VRMACIDSI-----CS------FITAL-HKLDDAAGLKRACEIAIPKFAH 757

Human   787 IMHS------FAKCIEVMGD-----GCLNN-EHFEELGGILKAKLEEHFKNQELRQVKRQDEDYD 839
            ||.:      ..:.::|:.|     ..:|: ||.|.:.|.::    :.|.|:...|...:....|
  Fly   758 IMRTDDQVAVVLRMLDVLYDVFKYVPAINSQEHAELIFGCIR----DIFTNKMACQFNEESGGGD 818

Human   840 EQVEESLQDEDDNDVYILTKVSDIL--------HSIFSSYKEKVLPWFEQLLPLIVNLICPHRPW 896
            ::..|    |.:||..:....:::.        ..:||.|..::..::.|.|..:     ..|..
  Fly   819 DECSE----ESENDEMLFENAANLFPMFGLTLQPELFSLYFGRLYHFYIQRLAKV-----KERDL 874

Human   897 PDRQWGLCIFDDVIEHCSPASFKYAEYF--LRPMLQYVC---DNSPEVRQAAAYGLGVMAQYGGD 956
            |:::  ..|:..:.:.|.......|.||  |||:  ::.   |:..:.||.:.:.||.:..:..:
  Fly   875 PEQR--AYIYGALADCCKALKGCCATYFDALRPI--FIAGSRDSDAKARQNSYFALGEIVFHSEE 935

Human   957 NYRPFCTEALPLLVRVIQSADSKTKENVNAT-ENCISAVGKIMKFKPDCVNVEEVLPHWLSWLPL 1020
              :.|  |:.|.:::.:  :::..:|:|.|. :|...||.:::...||.|.:.:|||.||:.|||
  Fly   936 --KSF--ESYPTILQAL--SEAIVRESVPAAMDNICGAVARLIVTNPDSVPLGQVLPVWLNHLPL 994

Human  1021 HEDKEEAVQTFNYLCDLIESNHPIV---LGPN-NTNLPKIFSIIAEGEMHEAIKHEDPCAKRLAN 1081
            .:|..|.        |:|:....::   ..|: ..:|.:|.:|..|....:.:...:.....:|
  Fly   995 KDDTVEN--------DVIQKAFRVLYLKARPSIEAHLEQILAITIEASYKKQMPDVETTESAVA- 1050

Human  1082 VVRQVQTSGGLWTECIAQLSPEQQAAIQEL 1111
            ::::::.:.......::.::||....:|.|
  Fly  1051 LIKEIRANYPELFSKVSNMNPEVFNYVQAL 1080

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IPO5	XP_005254109.1	KAP95	31..>652	CDD:227540	141/632 (22%)
		HEAT repeat	111..133	CDD:293787	3/21 (14%)
		HEAT repeat	150..178	CDD:293787	8/28 (29%)
		HEAT repeat	195..217	CDD:293787	4/27 (15%)
		HEAT repeat	235..263	CDD:293787	4/27 (15%)
		HEAT repeat	275..316	CDD:293787	9/40 (23%)
		Importin_rep_4	286..375	CDD:408579	21/95 (22%)
		HEAT repeat	373..405	CDD:293787	6/31 (19%)
		HEAT repeat	417..447	CDD:293787	9/36 (25%)
		HEAT repeat	459..486	CDD:293787	3/26 (12%)
		HEAT repeat	500..537	CDD:293787	7/36 (19%)
		HEAT repeat	549..582	CDD:293787	6/32 (19%)
		Importin_rep_6	783..892	CDD:465881	22/128 (17%)
		HEAT repeat	883..908	CDD:293787	4/24 (17%)
		HEAT repeat	921..954	CDD:293787	11/37 (30%)
		HEAT_EZ	937..984	CDD:463906	8/46 (17%)
		HEAT repeat	964..1000	CDD:293787	8/36 (22%)
		HEAT repeat	1009..1033	CDD:293787	10/23 (43%)
		Importin_rep_5	1023..1069	CDD:465877	9/49 (18%)
Arts	NP_001261957.1	IBN_N	29..90	CDD:197981	21/66 (32%)
		KAP95	<304..703	CDD:227540	94/425 (22%)
		HEAT repeat	356..384	CDD:293787	5/27 (19%)
		HEAT repeat	397..427	CDD:293787	9/29 (31%)
		HEAT repeat	438..473	CDD:293787	3/34 (9%)