DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment IPO5 and Karybeta3

DIOPT Version :10

Sequence 1:XP_005254109.1 Gene:IPO5 / 3843 HGNCID:6402 Length:1115 Species:Homo sapiens
Sequence 2:NP_524226.1 Gene:Karybeta3 / 40581 FlyBaseID:FBgn0087013 Length:1105 Species:Drosophila melanogaster


Alignment Length:1103 Identity:578/1103 - (52%)
Similarity:793/1103 - (71%) Gaps:11/1103 - (0%)


- Green bases have known domain annotations that are detailed below.


Human    23 AAEQQQFYLLLGNLLSPDNVVRKQAEETYENIPGQSKITFLLQAIRNTTAAEEARQMAAVLLRRL 87
            ||:|..|..||.:|||.||.||:||||.|.|:..:.|:|.||..|:|...:||||||||||||||
  Fly     2 AADQAHFQQLLASLLSTDNDVRQQAEEAYNNLSRELKVTHLLGNIQNGQQSEEARQMAAVLLRRL 66

Human    88 LSSAFDEVYPALPSDVQTAIKSELLMIIQMETQSSMRKKVCDIAAELARNLIDEDGNNQWPEGLK 152
            .::.|.:.|..||::.|..:..::|:.:|.|....:|:|:|::.||:||||||||.|||||:.|:
  Fly    67 FTTEFFDFYKGLPAESQNQLLQQILLAVQQEVTPQLRRKICEVVAEVARNLIDEDCNNQWPDILQ 131

Human   153 FLFDSVSSQNVGLREAALHIFWNFPGIFGNQQQHYLDVIKRMLVQCMQDQEHPSIRTLSARATAA 217
            |||...:|....|:|:||.||.:.|.|||||:..|:|:||:||.:.|.....|.:|..:.||..|
  Fly   132 FLFQCANSPTPQLQESALRIFSSVPSIFGNQEAQYIDLIKQMLAKSMDAGSDPEVRVQAVRAVGA 196

Human   218 FILAN--EHNVALFKHFADLLPGFLQAVNDSC-YQNDDSVLKSLVEIADTVPKYLRPHLEATLQL 279
            |||.:  |:..|:.|||||:||..:....::. .|:|.|:||.|:|:.:..||:|||.||...::
  Fly   197 FILYHDKENETAIHKHFADMLPRMIHITGETIEAQDDQSLLKLLIEMTENCPKFLRPQLEFIFEV 261

Human   280 SLKLCGDTSLNNMQRQLALEVIVTLSETAAAMLRKHTN--IVAQTIPQMLAMMVDLEEDEDWANA 342
            .:|:.......:..|.|.|||:|:|:|.|.:|:||..:  ||| .||.:|.||.||::||:|:.|
  Fly   262 CMKVFSSQDFEDSWRHLVLEVMVSLAENAPSMIRKRADKYIVA-LIPLILHMMTDLDDDENWSTA 325

Human   343 DELEDDDFDSNAVAGESALDRMACGLGGKLVLPMIKEHIMQMLQNPDWKYRHAGLMALSAIGEGC 407
            |.::|||...|.|..||:|||:|||||||:|||::...:..||.:.|||:|.|.|||:|||||||
  Fly   326 DVVDDDDHSDNNVIAESSLDRLACGLGGKIVLPLVMNALPVMLGHADWKHRFAALMAISAIGEGC 390

Human   408 HQQMEGILNEIVNFVLLFLQDPHPRVRYAACNAVGQMATDFAPGFQKKFHEKVIAALLQTMEDQG 472
            |:|||.||:|:::.||.||.|||||||||||||:|||:||||..|:||||.:||..||..::|..
  Fly   391 HKQMEAILDEVMSGVLNFLSDPHPRVRYAACNAIGQMSTDFAQTFEKKFHSQVIPGLLSLLDDVE 455

Human   473 NQRVQAHAAAALINFTEDCPKSLLIPYLDNLVKHLHSIMVLKLQELIQKGTKLVLEQVVTSIASV 537
            |.||||||.|||:||:|||||::|..|||.::..|.:|:..|.:||::||.|||||||||:||||
  Fly   456 NPRVQAHAGAALVNFSEDCPKNILTRYLDGIMAKLETILNSKFKELVEKGNKLVLEQVVTTIASV 520

Human   538 ADTAEEKFVPYYDLFMPSLKHIVENAVQKELRLLRGKTIECISLIGLAVGKEKFMQDASDVMQLL 602
            |||.|.:||.|||..||.||.|::||...:||:||||||||:||||||||:|||:.||.:||.:|
  Fly   521 ADTCESEFVAYYDRLMPCLKFIIQNANSDDLRMLRGKTIECVSLIGLAVGREKFIGDAGEVMDML 585

Human   603 LKTQTDFNDMEDDDPQISYMISAWARMCKILGKEFQQYLPVVMGPLMKTASIKPEVALLDTQDME 667
            |...|:..::.|||||.||:|:|||||||||||:|:||||:||||:|:||::|||||:||..::|
  Fly   586 LVNHTEGGELADDDPQTSYLITAWARMCKILGKQFEQYLPLVMGPVMRTATMKPEVAMLDNDEVE 650

Human   668 NMSDDDGWEFVNLGDQQSFGIKTAGLEEKSTACQMLVCYAKELKEGFVEYTEQVVKLMVPLLKFY 732
            ::..|..|.|:|||:||:|.|:|||:::|::||:||||||:||||||.||.|.||:.|:|:||||
  Fly   651 DIDGDVDWSFINLGEQQNFAIRTAGMDDKASACEMLVCYARELKEGFAEYAEDVVRQMLPMLKFY 715

Human   733 FHDGVRVAAAESMPLLLECARVRGPEYLTQMWHFMCDALIKAIGTEPDSDVLSEIMHSFAKCIEV 797
            ||||||.|||||:|.||:||:::||:||..||.|:|..|:|.|.|||:.||.||:::|.|||||.
  Fly   716 FHDGVRTAAAESLPYLLDCAKIKGPQYLEGMWMFICPELLKVIVTEPEPDVQSELLNSLAKCIET 780

Human   798 MGDGCLNNEHFEELGGILKAKLEEHFKNQELRQVKRQDEDYDEQVEESLQDEDDNDVYILTKVSD 862
            :|..|||.:..:::..|:...:.|||:..:.|...|.:||||:.|||.|.::||.|||||:|:.|
  Fly   781 LGPNCLNEDAMKQVLEIINKYVLEHFERADKRLAARNEEDYDDGVEEELAEQDDTDVYILSKIVD 845

Human   863 ILHSIFSSYKEKVLPWFEQLLPLIVNLICPHRPWPDRQWGLCIFDDVIEHCSPASFKYAEYFLRP 927
            |.|::|.:.|.:.||.|||:.|..|.|:.|.||..|||||||:|||:||.|.||...|.:.|...
  Fly   846 ITHALFQTNKAQFLPAFEQVAPHFVKLLEPSRPVADRQWGLCVFDDLIEFCGPACAPYQQIFTPA 910

Human   928 MLQYVCDNSPEVRQAAAYGLGVMAQYGGDNYRPFCTEALPLLVRVIQSADSKTKENVNATENCIS 992
            ::|||||.:||||||||||.||:.|:.|:.:...|.:.:||||:||....::..||::.|||.||
  Fly   911 LVQYVCDKAPEVRQAAAYGCGVLGQFAGEQFAHTCAQIIPLLVQVINDPKAREIENISPTENAIS 975

Human   993 AVGKIMKFKPDCV-NVEEVLPHWLSWLPLHEDKEEAVQTFNYLCDLIESNHPIVLGPNNTNLPKI 1056
            |..||:|:....: ||:|::..|.||||:.||.|||...:.|||||||.|||::||.||.|||:|
  Fly   976 AFAKILKYNNSALSNVDELIGVWFSWLPVSEDSEEAAHIYGYLCDLIEGNHPVILGANNGNLPRI 1040

Human  1057 FSIIAEGEMHEAIKHEDPCAKRLANVVRQVQTSGGLWTECIAQLSPEQQAAIQ----ELLNSA 1115
            .|||||....:.::.:.....|:..:|:||:::..:...|.:.||||||.|:|    ||.|.|
  Fly  1041 VSIIAESFCTKVVEAQSATGTRMLTIVKQVESNPEVMAACASTLSPEQQQALQDAYRELANVA 1103

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IPO5XP_005254109.1 KAP95 31..>652 CDD:227540 336/625 (54%)
HEAT repeat 111..133 CDD:293787 6/21 (29%)
HEAT repeat 150..178 CDD:293787 11/27 (41%)
HEAT repeat 195..217 CDD:293787 6/21 (29%)
HEAT repeat 235..263 CDD:293787 9/28 (32%)
HEAT repeat 275..316 CDD:293787 13/40 (33%)
Importin_rep_4 286..375 CDD:408579 45/90 (50%)
HEAT repeat 373..405 CDD:293787 16/31 (52%)
HEAT repeat 417..447 CDD:293787 21/29 (72%)
HEAT repeat 459..486 CDD:293787 15/26 (58%)
HEAT repeat 500..537 CDD:293787 20/36 (56%)
HEAT repeat 549..582 CDD:293787 20/32 (63%)
Importin_rep_6 783..892 CDD:465881 48/108 (44%)
HEAT repeat 883..908 CDD:293787 14/24 (58%)
HEAT repeat 921..954 CDD:293787 19/32 (59%)
HEAT_EZ 937..984 CDD:463906 22/46 (48%)
HEAT repeat 964..1000 CDD:293787 16/35 (46%)
HEAT repeat 1009..1033 CDD:293787 11/23 (48%)
Importin_rep_5 1023..1069 CDD:465877 27/45 (60%)
Karybeta3NP_524226.1 KAP95 6..>625 CDD:227540 330/619 (53%)
HEAT repeat 129..157 CDD:293787 11/27 (41%)
HEAT repeat 165..216 CDD:293787 21/50 (42%)
HEAT repeat 235..261 CDD:293787 12/25 (48%)
Importin_rep_4 268..358 CDD:408579 45/90 (50%)
HEAT repeat 272..305 CDD:293787 15/33 (45%)
HEAT repeat 357..385 CDD:293787 12/27 (44%)
HEAT repeat 401..429 CDD:293787 20/27 (74%)
HEAT repeat 442..473 CDD:293787 17/30 (57%)
HEAT repeat 485..519 CDD:293787 17/33 (52%)
HEAT repeat 532..565 CDD:293787 20/32 (63%)
Importin_rep_6 766..875 CDD:465881 48/108 (44%)
HEAT repeat 867..894 CDD:293787 16/26 (62%)
HEAT repeat 906..936 CDD:293787 18/29 (62%)
HEAT repeat 947..979 CDD:293787 14/31 (45%)
Importin_rep_5 1007..1059 CDD:465877 27/51 (53%)

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