DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycJ and CCNE2

DIOPT Version :9

Sequence 1:	NP_523903.1	Gene:	CycJ / 38428	FlyBaseID:	FBgn0010317	Length:	386	Species:	Drosophila melanogaster
Sequence 2:	NP_477097.1	Gene:	CCNE2 / 9134	HGNCID:	1590	Length:	404	Species:	Homo sapiens

Alignment Length:	323	Identity:	75/323 - (23%)
Similarity:	134/323 - (41%)	Gaps:	83/323 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 ARDIFLTMREQELSRRPLFY------------LSPQLNERRRMLQLLKLATSAHKLSRCALHLAV 92
            :::::|.|.::| ||    |            |.||:  |..:|..|......:.|.|...:||.
Human   110 SKEVWLNMLKKE-SR----YVHDKHFEVLHSDLEPQM--RSILLDWLLEVCEVYTLHRETFYLAQ 167

  Fly    93 YYMDRFVDYYK-IRPDKLLLVAITCLHIAAQIENTDAFIPRYSEMNRLVKNAYTAFEYKAVERKI 156
            .:.|||:...| |..:.|.|:.||.|.||:::|  :.:.|:..|...:...|.:..:...:|..|
Human   168 DFFDRFMLTQKDINKNMLQLIGITSLFIASKLE--EIYAPKLQEFAYVTDGACSEEDILRMELII 230

  Fly   157 LCFLNFELIRPTTASFVELFACSFLTRSDFKNYIE-MLDEYERNHHTQPYQRYISFEEMLSILAQ 220
            |..|.:||...|..|::.|    ||.....|:..: :|.:|.:       :.:|...::|. |..
Human   231 LKALKWELCPVTIISWLNL----FLQVDALKDAPKVLLPQYSQ-------ETFIQIAQLLD-LCI 283

  Fly   221 LLLRMADYTLYISRFANDLPSLLAAA-C----IAAVRQVSGVRRWS------EYLVGLTSYTEAN 274
            |.:...::...|         |.||| |    |..|::.||: .|.      :::|
Human   284 LAIDSLEFQYRI---------LTAAALCHFTSIEVVKKASGL-EWDSISECVDWMV--------- 329

  Fly   275 VEPYMNVLTDYYYYHVIQTDYGSP-SVQTNQSLASPDSGFEESFTENTN-LVVSDEVVTVETY 335
              |::||:..           .|| .::|.:.:...|   ..:...:|| |.:.:||..:.|:
Human   330 --PFVNVVKS-----------TSPVKLKTFKKIPMED---RHNIQTHTNYLAMLEEVNYINTF 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycJ	NP_523903.1	Cyclin_N	42..164	CDD:278560	36/134 (27%)
CycJ	NP_523903.1	Cyclin_C	<225..>286	CDD:281044	15/71 (21%)
CCNE2	NP_477097.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44
		Cyclin_N	112..239	CDD:278560	37/135 (27%)
		Cyclin_C	241..361	CDD:281044	31/166 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D993640at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820