DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CycJ and CCNF

DIOPT Version :9

Sequence 1:	NP_523903.1	Gene:	CycJ / 38428	FlyBaseID:	FBgn0010317	Length:	386	Species:	Drosophila melanogaster
Sequence 2:	NP_001752.2	Gene:	CCNF / 899	HGNCID:	1591	Length:	786	Species:	Homo sapiens

Alignment Length:	362	Identity:	83/362 - (22%)
Similarity:	139/362 - (38%)	Gaps:	77/362 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 RKLK----KTCPQADVERLAKTHWLTDYARDIFLTMR------------EQELSRRPLFYLSPQL 64
            |||:    |.|.:|.:. |||.   ...|..:.|.:|            .|.:|::.:|.:...|
Human   245 RKLRDYAAKGCWEAQLS-LAKA---CANANQLGLEVRASSEIVCQLFQASQAVSKQQVFSVQKGL 305

  Fly    65 NERRRML---QLLKLATSAHKLSRCALHLAVYYMDRFVDYYKIRPDKLLLVAITCLHIAAQIENT 126
            |:..|.:   .|:::||.....|.| |||.|..:||::....:...:|.|:.|.|:.|..:..:.
Human   306 NDTMRYILIDWLVEVATMKDFTSLC-LHLTVECVDRYLRRRLVPRYRLQLLGIACMVICTRFISK 369

  Fly   127 DAFIPRYSEMNRLVKNAYTAFEYKAVERKILCFLNFELIRPTTASFVELFACSFLTRSDFKNYIE 191
            :....|  |...|..|.|...:...:..:|:..|..::..||..              |:|..:.
Human   370 EILTIR--EAVWLTDNTYKYEDLVRMMGEIVSALEGKIRVPTVV--------------DYKEVLL 418

  Fly   192 MLDEYE-RNHHTQPYQRYISFEEMLSILAQLLLRMADYTLYISRFANDLPSLLAAACIAAVRQVS 255
            .|...| |..|            :.|.|.:|.|.....:.|       .|:.||||.:...|...
Human   419 TLVPVELRTQH------------LCSFLCELSLLHTSLSAY-------APARLAAAALLLARLTH 464

  Fly   256 G-VRRWSEYLVGLTSYTEANVEPYMNVLTDYYYYHVIQTDYGSPSVQTNQSLASPDSGFEESFTE 319
            | .:.|:..|..||.::..::.|.:..|....::.....||...|:          :..::.|.:
Human   465 GQTQPWTTQLWDLTGFSYEDLIPCVLSLHKKCFHDDAPKDYRQVSL----------TAVKQRFED 519

  Fly   320 NTNLVVSDEVVTVETYNIITVQL---QDPSPHSSTFL 353
            .....:|.|.|.  :|:.:...|   || ||...|||
Human   520 KRYGEISQEEVL--SYSQLCAALGVTQD-SPDPPTFL 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycJ	NP_523903.1	Cyclin_N	42..164	CDD:278560	31/136 (23%)
CycJ	NP_523903.1	Cyclin_C	<225..>286	CDD:281044	14/61 (23%)
CCNF	NP_001752.2	Nuclear localization signal 1. /evidence=ECO:0000269\|PubMed:10716937	20..28
		F-box domain	29..76
		FBOX	35..73	CDD:197608
		TPR	<88..>146	CDD:223861
		SLR repeat	88..112	CDD:276807
		Cyclin_N	281..406	CDD:278560	29/127 (23%)
		Cyclin_C	421..531	CDD:281044	27/138 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	564..593
		Nuclear localization signal 2. /evidence=ECO:0000269\|PubMed:10716937	568..574
		PEST	582..766
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	675..738
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900