DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycJ and CCNA1

DIOPT Version :9

Sequence 1:	NP_523903.1	Gene:	CycJ / 38428	FlyBaseID:	FBgn0010317	Length:	386	Species:	Drosophila melanogaster
Sequence 2:	NP_003905.1	Gene:	CCNA1 / 8900	HGNCID:	1577	Length:	465	Species:	Homo sapiens

Alignment Length:	256	Identity:	68/256 - (26%)
Similarity:	107/256 - (41%)	Gaps:	38/256 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LTDYARDIFLTMREQELSRRP-LFYL--SPQLNERRR--MLQLLKLATSAHKLSRCALHLAVYYM 95
            :|:||.:|:..:||.|:..|| ..|:  .|.:.|..|  ::..|......:||....|:|||.::
Human   208 VTEYAEEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFL 272

  Fly    96 DRFVDYYKIRPDKLLLVAITCLHIAAQIENTDAFIPRYSEMNRLVKNAYTAFEYKAVERKILCFL 160
            |||:....:...||.||....:.:|::.|  :.:.|...|...:..:.||..:...:|..:|..|
Human   273 DRFLSCMSVLRGKLQLVGTAAMLLASKYE--EIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVL 335

  Fly   161 NFELIRPTTASFVELFACSFLTRSDFKNYIEMLDEYERNHHTQPYQRYISFEEMLSILAQLLLRM 225
            .|:|..|||..|:    ..:|.|.......|.|.:|                     :|:|.|..
Human   336 AFDLTVPTTNQFL----LQYLRRQGVCVRTENLAKY---------------------VAELSLLE 375

  Fly   226 ADYTLYISRFANDLPSLLAAACIAAVRQVSGVRRWSEYLVGLTSYTEANVEPYMNVLTDYY 286
            ||      .|...||||:|||.............|.|.|...|.|:.:.:.|.::.|...|
Human   376 AD------PFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGYSLSEIVPCLSELHKAY 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycJ	NP_523903.1	Cyclin_N	42..164	CDD:278560	34/126 (27%)
CycJ	NP_523903.1	Cyclin_C	<225..>286	CDD:281044	17/60 (28%)
CCNA1	NP_003905.1	Cyclin_N2	71..>145	CDD:293109
		Cyclin_N	214..340	CDD:278560	34/127 (27%)
		Cyclin_C	342..459	CDD:281044	30/120 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D993640at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820