DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment armi and Znfx1

DIOPT Version :9

Sequence 1:	NP_001014556.1	Gene:	armi / 38427	FlyBaseID:	FBgn0041164	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	NP_001028368.2	Gene:	Znfx1 / 98999	MGIID:	2138982	Length:	1909	Species:	Mus musculus

Alignment Length:	1221	Identity:	229/1221 - (18%)
Similarity:	415/1221 - (33%)	Gaps:	414/1221 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 EEKMDQQLKANPNEINGVLSNKIAEL-TH--------------GLSEMDVSKESSCTARK----- 80
            |..:|::....||.|:|...:....| ||              |:.::..|.|..|..::
Mouse   337 EVHLDEKPFLRPNIISGKYESTAVYLDTHFRLLREDFVRPLREGILKLLQSFEDQCLRKRKFDDI 401

  Fly    81 ------GVITSLDGDRGVIDKDVLFETKVAEDIILDLHVGCVVEYLTFTTGEAMRVVKVKSILEH 139
                  .:||.:....|::.| |.|:||                        .:::|:
Mouse   402 RIYFDARIITPMCSASGIVYK-VQFDTK------------------------PLKLVR------- 434

  Fly   140 SWEDTSQKEIEKAVDNLKNEKPTFFNTETRSVLGLISQRLASSIDVETEYGQLTVELDNIEMNFI 204
             |:::.:......|...|:...||       :...:|.|         |:..|...:  :::.|
Mouse   435 -WQNSKRLLYGSLVCMSKDNFETF-------LFATVSNR---------EHEDLCQGI--VQLCF- 479

  Fly   205 PTNGDRVRLECNIQLDDGFVDKQGEILEVTKLFPTRIQEGEKCIVERVYVHMVVLGPETYILKTD 269
              |....:|..::|..|.|:     ::|.|..|             ..|.|  ||.....:.:.|
Mouse   480 --NEQSQQLLADVQPSDSFL-----MVETTAYF-------------EAYRH--VLEGLQEVQEED 522

  Fly   270 LPTGTDLHLGDIVLADLIEC-QYSKFTRRAI-----KITPLEKNFGATKLTQQSSMGSSGSG-KA 327
            :|          ...::::| .|.:..|..:     ..|||.:|        .|:|..|..| :|
Mouse   523 VP----------FQRNIVQCDSYVRNPRYLLMGGRYDFTPLMEN--------PSAMRKSLRGAEA 569

  Fly   328 VTVTGVNRFITAELWQKESVSLKLTNNLNRTLRLESITVCNDSESQLSVV-SPLESKEISSGSEI 391
            :....:|.|...:...||  :|||.::....|:. ::|      .:|::: .|..:.:...|.:|
Mouse   570 LRHPRINVFDFGQWPSKE--ALKLDDSQMEALQF-ALT------KELAIIQGPPGTGKTYVGLKI 625

  Fly   392 T-------VTFEIHTQFLGEAIEKYVLNFDLLKVRRVFTVIVCKTK-------EEVAEAEKRMIA 442
            .       ..::|:||           .|.:|        :||.|.       |.:...:|..|
Mouse   626 VQALLTNKSVWQINTQ-----------TFPIL--------VVCYTNHALDQFLEGIYGCQKTSI- 670

  Fly   443 AEALMAPGRNSQERSRFYANQVWCNKVDVIPGQQIVTKRRF-----VALRLGCFEVPKELRQICL 502
               :...||::.|..:.:..            :::..||.|     :.||.....:..|:::
Mouse   671 ---VRVGGRSNSEILKQFTL------------RELRNKREFRRTLPMHLRRAYMSIVTEMKE--- 717

  Fly   503 TSERRQEMIKAIEQHYSFLTEPLSIKTYMHRFRLLLHLEEIECFVNFRNYDRDRAHFLRDGEFLT 567
            :.::.||..:.:|             ..||.   :|..:.:|.:::.::::...:..::|.:::.
Mouse   718 SEQKLQEGAQTLE-------------CTMHG---VLREQHLEKYISAQHWESLMSGPVQDADWVC 766

  Fly   568 LQIENLAERRPS----------LVIGDTLRVINPWSDPDSQTTKSYEGIIHKVLFDRILLKFHSS 622
            :|        ||          |.:|...:..:| :.|::  |...||
Mouse   767 VQ--------PSKHSMILEWLGLGVGSFTQSASP-AGPEN--TAQAEG----------------- 803

  Fly   623 FQEKYNGEDYRLEFYFSRYSFRKQHHAISKIVGVMGEDFLFPSKVTKREN------------PQL 675
             :|:..||:..     |.....::...|.....:..|:.:.|.:..|.||            .:|
Mouse   804 -EEEEEGEEEG-----SLIEIAEEADLIQADRVIEEEEVVRPRRRKKEENGTDQELAKMLLAMRL 862

  Fly   676 DVYMKDDDMYLYDSKLEWYNQSLN--------SIQKRAVFNILRGEAENIPYVLFGPPGSGKTMT 732
            |..:.........:..||..|...        .::.|.:..:.:.||..|..|  ..........
Mouse   863 DQEVPGTTAGPEQATEEWETQRGQKKKMKRRVKVELRKLNTMTKAEANGIQDV--WQLDLSSRWQ 925

  Fly   733 LIETLLQLVRNLPGARILVGTPSNSSADLVTKRLIDSKALLQGDFIRLVSYN------------- 784
            |....||:.:                ||  |:|             |::||.
Mouse   926 LYRLWLQMYQ----------------AD--TRR-------------RILSYERQYRTWAERMAEL 959

  Fly   785 QVEKDLIPPEIMSYCATSDVGAVGSCEDKMMVTESGLKLRCQAKFIGTHRITISTCTTLGNFLQL 849
            ::::||   .|:     .|...||      |.|....|.|                    ..||.
Mouse   960 RLQEDL---HIL-----KDAEVVG------MTTTGAAKYR--------------------QILQQ 990

  Fly   850 GFPAGHFTHVLFDEAGQCTEPETMVPIVMLTKKRSQVVLSGDPRQLQ-SIVTSRIASKMGFSISF 913
            ..|    ..|:.:||.:..|..|   |..|:|....::|.||.:||: |.....:|......:|.
Mouse   991 VEP----RIVIVEEAAEVLEAHT---IATLSKACQHLILIGDHQQLRPSANVYDLAKNFNLEVSL 1048

  Fly   914 LERLLERSPYRKDLQRFPESSGYNPLVLTKLLYNYRALPSIMSIYSRLFYDDELIPVLSEKDSRE 978
            .|||::.:                 :...:|.|.:|..|.|..:.:...|.|
Mouse  1049 FERLVKVN-----------------IPFVRLNYQHRMRPEIARLLTPHIYQD------------- 1083

  Fly   979 SRLLSKLRCVFESEKDIPQAHGTFFYGIIGENRQNNDSPSWFNPQEVREVFLMTIALYRANVTAD 1043
               |.....|.:.|:....:...||.......::..:..|..|..|...|..:...|........
Mouse  1084 ---LENHPSVLKYEQIKGVSSNLFFVEHNFPEQEIQEGKSHQNQHEAHFVVELCQYLLCQEYLPS 1145

  Fly  1044 QIGIITPYQKQVKMLRSMFIGTDVVMP-------KIGSVEEFQGQERDIILISTVRSSEEILRMD 1101
            ||.|:|.|..|:..||.:       ||       |:..|:::||:|.||||:|.|||::|
Mouse  1146 QITILTTYTGQLFCLRKL-------MPVKTFAGIKVHVVDKYQGEENDIILLSLVRSNQE----- 1198

  Fly  1102 ARFSLGFVRCSKRLNVAVSRARAMMIIFGNPHLLAVDECWRQLILFCVKNN 1152
              ..:||::...|:.||:|||:..|...||..:||....|.::|....:||
Mouse  1199 --GKVGFLQIPNRICVALSRAKKGMYCIGNMQMLAKVPLWSRIIHTLRENN 1247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
armi	NP_001014556.1	AAA_11	698..902	CDD:289831	42/225 (19%)
		AAA_19	720..768	CDD:289986	8/47 (17%)
		DNA2	<840..1155	CDD:224037	80/321 (25%)
		UvrD_C_2	909..1132	CDD:304668	55/229 (24%)
Znfx1	NP_001028368.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..133
		EEXXEc_NFX1	591..>674	CDD:350694	18/112 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	787..813		8/46 (17%)
		AAA_11	<897..1031	CDD:404072	41/207 (20%)
		EEXXEc_NFX1	<971..1066	CDD:350694	30/144 (21%)
		SF1_C_Upf1	1068..1244	CDD:350195	53/205 (26%)
		NF-X1-zinc-finger	1365..1410	CDD:100116
		Keratin_B2	1425..1563	CDD:366678
		NF-X1-zinc-finger	1453..1497	CDD:100116
		PRK03918	<1597..>1808	CDD:235175
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900