DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment armi and HCS1

DIOPT Version :9

Sequence 1:	NP_001014556.1	Gene:	armi / 38427	FlyBaseID:	FBgn0041164	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	NP_012908.1	Gene:	HCS1 / 853852	SGDID:	S000001500	Length:	683	Species:	Saccharomyces cerevisiae

Alignment Length:	766	Identity:	191/766 - (24%)
Similarity:	315/766 - (41%)	Gaps:	206/766 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   495 KELRQICLTS---ERRQEMIKAIEQHYSFLTEPLSIKTYMHRFRLL--LHLEEIECFVNFRNYDR 554
            |||....|:|   ||.|::     |..|.|...|||:..:.....:  :|||.|
Yeast     3 KELASKFLSSIKHEREQDI-----QTTSRLLTTLSIQQLVQNGLAINNIHLENI----------- 51

  Fly   555 DRAHFLRDGEFLTLQIE---NLAE----RRPSLVIGDTLRV------INPWSDP-------DSQT 599
                  |.|....|.:|   |||.    :|..:.:||.:.|      :|..:.|       ||..
Yeast    52 ------RSGLIGKLYMELGPNLAVNDKIQRGDIKVGDIVLVRPAKTKVNTKTKPKVKKVSEDSNG 110

  Fly   600 TKS-YEGIIHKVLFDRILLKFHSSFQEKYNGEDYRLEFYFSRYSFRKQHHAISKIVGVMGEDFLF 663
            .:: ..|:::|:...:|.:....|       :|.....:   ||:.|.:  |.|...|:..:.:.
Yeast   111 EQAECSGVVYKMSDTQITIALEES-------QDVIATTF---YSYSKLY--ILKTTNVVTYNRME 163

  Fly   664 PS--KVTKRENPQLD---VYMKDDDMYL-----YDSKLEWYNQSLNSIQKRAV-FNILRGEAENI 717
            .:  |:::..:|..|   .|:.::..::     :.:...:.|.:||..||.|: |.|     .|.
Yeast   164 STMRKLSEISSPIQDKIIQYLVNERPFIPNTNSFQNIKSFLNPNLNDSQKTAINFAI-----NND 223

  Fly   718 PYVLFGPPGSGKTMTLIETLLQLVRNLPGARILVGTPSNSSADLVTKR---LIDSKALLQ-GDFI 778
            ..::.||||:|||.||||.:.||:...|..|||:..|||.|.|.:.:|   |:.:..||: |...
Yeast   224 LTIIHGPPGTGKTFTLIELIQQLLIKNPEERILICGPSNISVDTILERLTPLVPNNLLLRIGHPA 288

  Fly   779 RLVSYNQ------------VEKDLIPPEIMSYCATSDVGAVGSCEDKMMVTESGLKLRCQAK--- 828
            ||:..|:            :.|| |..||                ||::.....||...|.|
Yeast   289 RLLDSNKRHSLDILSKKNTIVKD-ISQEI----------------DKLIQENKKLKNYKQRKENW 336

  Fly   829 --------------------FIGTHRITIST---------CTTL---GNFLQLGFPAGHFTHVLF 861
                                .|...||.::|         |:..   .|| ||      |..::.
Yeast   337 NEIKLLRKDLKKREFKTIKDLIIQSRIVVTTLHGSSSRELCSLYRDDPNF-QL------FDTLII 394

  Fly   862 DEAGQCTEPETMVPIVMLTKKRSQVVLSGDPRQLQSIVTSRIASKM--GFSISFLERLLERSPYR 924
            ||..|..||:..:|::....:..::||:||.:||...:.:.....:  ....:..:|:::..| :
Yeast   395 DEVSQAMEPQCWIPLIAHQNQFHKLVLAGDNKQLPPTIKTEDDKNVIHNLETTLFDRIIKIFP-K 458

  Fly   925 KDLQRFPESSGYNPLVLTKLLYNYRALPSIMSIYSRLFYDDELIPVLSEKDSR-ESRLLSKLRCV 988
            :|:.:|             |...||....||...|...|:.:|:     .|:. .:|||..|..|
Yeast   459 RDMVKF-------------LNVQYRMNQKIMEFPSHSMYNGKLL-----ADATVANRLLIDLPTV 505

  Fly   989 --FESEKDIPQAHGTFFYGIIGENRQNNDSP-----SWFNPQEVREVFLMTIALYRANVTADQIG 1046
              ..||.|........:|...|:..|.....     |.:|..|:..|......|...||..:.||
Yeast   506 DATPSEDDDDTKIPLIWYDTQGDEFQETADEATILGSKYNEGEIAIVKEHIENLRSFNVPENSIG 570

  Fly  1047 IITPYQKQVKMLRSMFIG----TDVVMPKIGSVEEFQGQERDIILISTVRSSEEILRMDARFSLG 1107
            :|:||..||..|:.:...    ||:   :|.:|:.|||:|:|:|::|.|||:|       :|.:|
Yeast   571 VISPYNAQVSHLKKLIHDELKLTDI---EISTVDGFQGREKDVIILSLVRSNE-------KFEVG 625

  Fly  1108 FVRCSKRLNVAVSRARAMMIIFGNPHLLAVDEC-------WRQLILFCVKN 1151
            |::..:|||||::|.|..:::.||..:|  ..|       |.:   :|.:|
Yeast   626 FLKEERRLNVAMTRPRRQLVVVGNIEVL--QRCGNKYLKSWSE---WCEEN 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
armi	NP_001014556.1	AAA_11	698..902	CDD:289831	71/255 (28%)
		AAA_19	720..768	CDD:289986	24/50 (48%)
		DNA2	<840..1155	CDD:224037	89/336 (26%)
		UvrD_C_2	909..1132	CDD:304668	65/234 (28%)
HCS1	NP_012908.1	TIGR00376	15..679	CDD:273041	186/754 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810