Protein Alignment armi and UPF1

DIOPT Version :10

• Sequence 1: NP_647816.2
• Gene: armi / 38427
• FlyBaseID: FBgn0041164
• Length: 1188
• Species: Drosophila melanogaster
• Sequence 2: XP_016882594.1
• Gene: UPF1 / 5976
• HGNCID: 9962
• Length: 1137
• Species: Homo sapiens
• Alignment Length: 610
• Identity: 163/610 - (26%)
• Similarity: 256/610 - (41%)
• Gaps: 135/610 - (22%)

  Fly   582 IGDTLRVINPWSDPDSQTTKSYEGIIHKVLFDRILLKFHSS----FQEKYNGEDYRLEFYFSRYS 642
            ||..::|      ||:.....     |....|.|.::..||    .:..:|   ::::|.:...|
Human   388 IGHVIKV------PDNANLTQ-----HTDYGDEIAIELRSSVGAPVEVTHN---FQVDFVWKSTS 438

  Fly   643 FRKQHHAIS---------------KIVGVMGEDFLFPSKVTKRENPQLDVYMKDDDMYLYDSKLE 692
            |.:...|:.               |::|...||.:...::.||...|          .|.|
Human   439 FDRMQSALKTFAVDETSVSGYIYHKLLGHEVEDVIIKCQLPKRFTAQ----------GLPD---- 489

  Fly   693 WYNQSLNSIQKRAVFNILRGEAENIPYVLFGPPGSGKTMTLIETLLQLVRNLPGARILVGTPSNS 757
                 ||..|..||..:|:....    ::.||||:|||:|....:..|.|...|. :||..|||.
Human   490 -----LNHSQVYAVKTVLQRPLS----LIQGPPGTGKTVTSATIVYHLARQGNGP-VLVCAPSNI 544

  Fly   758 SADLVTKRL-----------IDSKALLQGDFIRLVSYNQVEKDLIPPEIMSYCATSD-VGAVGSC 810
            :.|.:|:::           ..|:..:......|..:||:......||:.......| .|.:.|.
Human   545 AVDQLTEKIHQTGLKVVRLCAKSREAIDSPVSFLALHNQIRNMDSMPELQKLQQLKDETGELSSA 609

  Fly   811 EDKMMVTESGLKLRCQAKFIGTHRITISTCTTLGNFLQLGFP---AGHFTHVLFDEAGQCTEPET 872
            ::|..   ..||...:.:.:....:...||...|:      |   ...|..:|.||:.|.||||.
Human   610 DEKRY---RALKRTAERELLMNADVICCTCVGAGD------PRLAKMQFRSILIDESTQATEPEC 665

  Fly   873 MVPIVMLTKKRSQVVLSGDPRQLQSIVTSRIASKMGFSISFLERLLERSPYRKDLQRFPESSGYN 937
            |||:|:..|   |::|.||..||..:|..:.|:|.|.|.|..|||:              ..|..
Human   666 MVPVVLGAK---QLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLV--------------VLGIR 713

  Fly   938 PLVLTKLLYNYRALPSIMSIYSRLFYDDELIPVLSEKDSRESRLLSKLRCVFE---SEKDIPQAH 999
            |:   :|...||..|::.:..|.:||:..|...::..|        :::..|:   .:.|.|.
Human   714 PI---RLQVQYRMHPALSAFPSNIFYEGSLQNGVTAAD--------RVKKGFDFQWPQPDKPM-- 765

  Fly  1000 GTFFYGIIGENRQNNDSPSWFNPQEVREVFLMTIALYRANVTADQIGIITPYQKQVKML--RSMF 1062
              |||...|:....:...|:.|..|...|..:|..|.:|....|||||||||:.|...|  ...|
Human   766 --FFYVTQGQEEIASSGTSYLNRTEAANVEKITTKLLKAGAKPDQIGIITPYEGQRSYLVQYMQF 828

  Fly  1063 IGT-------DVVMPKIGSVEEFQGQERDIILISTVRSSEEILRMDARFSLGFVRCSKRLNVAVS 1120
            .|:       :|   :|.||:.|||:|:|.|::|.||::|       ...:||:...:|||||::
Human   829 SGSLHTKLYQEV---EIASVDAFQGREKDFIILSCVRANE-------HQGIGFLNDPRRLNVALT 883

  Fly  1121 RARAMMIIFGNPHLLAVDECWRQLI 1145
            |||..:||.|||..|:....|..|:
Human   884 RARYGVIIVGNPKALSKQPLWNHLL 908

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
armi	NP_647816.2	DEXXQc_Mov10L1	697..949	CDD:350836	72/266 (27%)
		DNA2	<829..1148	CDD:440729	103/332 (31%)
UPF1	XP_016882594.1	UPF1_Zn_bind	121..272	CDD:401391
		TIGR00376	370..919	CDD:273041	163/610 (27%)
		DEXXQc_UPF1	489..722	CDD:350797	73/275 (27%)