DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment armi and ZNFX1

DIOPT Version :9

Sequence 1:	NP_001014556.1	Gene:	armi / 38427	FlyBaseID:	FBgn0041164	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	NP_066363.1	Gene:	ZNFX1 / 57169	HGNCID:	29271	Length:	1918	Species:	Homo sapiens

Alignment Length:	1215	Identity:	234/1215 - (19%)
Similarity:	409/1215 - (33%)	Gaps:	397/1215 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FTYVSKFFTNPDRNREDILESLDRENSFLDQKLMEEKMDQQLKANPNEINGVLSNKIAELTHGLS 66
            |..:.:.|..|  .||.|||.|   .||.||.|.:.|.|        :|......:|
Human   373 FRLLREDFVRP--LREGILELL---QSFEDQGLRKRKFD--------DIRIYFDTRI-------- 416

  Fly    67 EMDVSKESSCTARKGVITSLDGDRGVIDKDVLFETKVAEDIILDLHVGCVVEYLTFTTGEAMRVV 131
                            ||.:....|::.| |.|:||.                |.|...:..:.:
Human   417 ----------------ITPMCSSSGIVYK-VQFDTKP----------------LKFVRWQNSKRL 448

  Fly   132 KVKSILEHSWEDTSQKEIEKAVDNLKNEK------PTFFNTETRSVLGLISQRLASSIDVET--- 187
            ...|::..| :|..:..:...|.|.:.|.      ...||.:::.:|..: |...|.:.|||
Human   449 LYGSLVCMS-KDNFETFLFATVSNREQEDLCRGIVQLCFNEQSQQLLAEV-QPSDSFLMVETTAY 511

  Fly   188 --EYGQLTVELDNIEMNFIPTNGDRVRLECNIQLDDGFVDKQGEILEVTKLFPTRIQEGEKCIVE 250
              .|..:...|..::...:|.  .|..:|||..:.:......|...:.|.|.......||  .:.
Human   512 FEAYRHVLEGLQEVQEEDVPF--QRNIVECNSHVKEPRYLLMGGRYDFTPLIENPSATGE--FLR 572

  Fly   251 RV----YVHMVVLGPETYILKTDLPTGTDLHLGDIVLADLIECQYSKFTRRAIKITPLEKNFGAT 311
            .|    :..:.||.|..:      |:...|.|.|..:..|   |::
Human   573 NVEGLRHPRINVLDPGQW------PSKEALKLDDSQMEAL---QFA------------------- 609

  Fly   312 KLTQQSSM--GSSGSGKAVTVTGVNRFITAELWQKESVSLKLTNNLNRTLRLESITVCNDSESQL 374
             ||::.::  |..|:||..                  |.||:...|          :.|:|..|:
Human   610 -LTRELAIIQGPPGTGKTY------------------VGLKIVQAL----------LTNESVWQI 645

  Fly   375 SVVSPLESKEISSGSEITVTFEIHTQFLGEAIEKYVLNFDLLKVRRVFTVIVCKTK-------EE 432
            |                              ::|:.:            ::||.|.       |.
Human   646 S------------------------------LQKFPI------------LVVCYTNHALDQFLEG 668

  Fly   433 VAEAEKRMIAAEALMAPGRNSQERSRFYANQVWCNKVDVIPGQQIVTKRRFVALRLGCFEVPKEL 497
            :...:|..|    :...||::.|..:.:..:...||.:......:..:|.::::.....|..:||
Human   669 IYNCQKTSI----VRVGGRSNSEILKQFTLRELRNKREFRRNLPMHLRRAYMSIMTQMKESEQEL 729

  Fly   498 RQICLTSE-------RRQEMIKAIE-QHY-SFLTEPLSIKTYMHRFRLLLHLEEIECFVNFRNYD 553
            .:...|.|       |.|.:.|.|. ||: |.:..|:....::             ||.::::
Human   730 HEGAKTLECTMRGVLREQYLQKYISPQHWESLMNGPVQDSEWI-------------CFQHWKH-- 779

  Fly   554 RDRAHFLRDGEFLTLQIENLAERRPSLVIGDTLRVINPWSDPDSQTTKSYEGIIHKVLFDRILLK 618
                         ::.:|.|     .|.:|...:.::| :.|::  |...||
Human   780 -------------SMMLEWL-----GLGVGSFTQSVSP-AGPEN--TAQAEG------------- 810

  Fly   619 FHSSFQEKYNGEDYRLEFYFSRYSFRKQHHAISKIVGVMGEDFLFPSKVTKRENPQLDVYMKDDD 683
                 .|:..||:..     |.....::...|.....:..|:.:.|.:..|.|:.      .|.:
Human   811 -----DEEEEGEEES-----SLIEIAEEADLIQADRVIEEEEVVRPQRRKKEESG------ADQE 859

  Fly   684 M--YLYDSKL----------------EWYNQSLNSIQKRAVFNILRGEAENIPYVLFGPPGSGKT 730
            :  .|...:|                ||..|   ..||:.:...::.|...:           .|
Human   860 LAKMLLAMRLDHCGTGTAAGQEQATGEWQTQ---RNQKKKMKKRVKDELRKL-----------NT 910

  Fly   731 MTLIETLLQLVRNLPGARILVGTPSNSSADLVTKRLIDSKALLQGDFIRLVSYNQVEKDLIPPEI 795
            ||..|                   :|...| |.:..:.|:..|...:::|...:...|      |
Human   911 MTAAE-------------------ANEIED-VWQLDLSSRWQLYRLWLQLYQADTRRK------I 949

  Fly   796 MSYCATSDVGAVGSCEDKMMVTESGLKLRCQAKFIGTHRITISTCTTLGNFLQLGFPAGHFTHVL 860
            :||.......|....|.::   :..|.:...|:.:|   :|.:........||...|    ..|:
Human   950 LSYERQYRTSAERMAELRL---QEDLHILKDAQVVG---MTTTGAAKYRQILQKVEP----RIVI 1004

  Fly   861 FDEAGQCTEPETMVPIVMLTKKRSQVVLSGDPRQLQ-SIVTSRIASKMGFSISFLERLLERSPYR 924
            .:||.:..|..|   |..|:|....::|.||.:||: |.....:|......:|..|||::.:
Human  1005 VEEAAEVLEAHT---IATLSKACQHLILIGDHQQLRPSANVYDLAKNFNLEVSLFERLVKVN--- 1063

  Fly   925 KDLQRFPESSGYNPLVLTKLLYNYRALPSIMSIYSRLFYDDELIPVLSEKDSRESRLLSKLRCVF 989
                          :...:|.|.:|..|.|..:.:...|.|                |.....|.
Human  1064 --------------IPFVRLNYQHRMCPEIARLLTPHIYQD----------------LENHPSVL 1098

  Fly   990 ESEKDIPQAHGTFFYGIIGENRQNNDSPSWFNPQEVRE----------VFLMTIALY--RANVTA 1042
            :.||....:...||.       ::|     |..||::|          .|::.:..|  ......
Human  1099 KYEKIKGVSSNLFFV-------EHN-----FPEQEIQEGKSHQNQHEAHFVVELCKYFLCQEYLP 1151

  Fly  1043 DQIGIITPYQKQVKMLRSMFIGTDVVMPKIGSVEEFQGQERDIILISTVRSSEEILRMDARFSLG 1107
            .||.|:|.|..|:..||.:.........::..|:::||:|.||||:|.|||::|       ..:|
Human  1152 SQITILTTYTGQLFCLRKLMPAKTFAGVRVHVVDKYQGEENDIILLSLVRSNQE-------GKVG 1209

  Fly  1108 FVRCSKRLNVAVSRARAMMIIFGNPHLLAVDECWRQLILFCVKNN 1152
            |::.|.|:.||:|||:..|...||..:||....|.::|....:||
Human  1210 FLQISNRICVALSRAKKGMYCIGNMQMLAKVPLWSKIIHTLRENN 1254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
armi	NP_001014556.1	AAA_11	698..902	CDD:289831	40/204 (20%)
		AAA_19	720..768	CDD:289986	7/47 (15%)
		DNA2	<840..1155	CDD:224037	81/326 (25%)
		UvrD_C_2	909..1132	CDD:304668	56/234 (24%)
ZNFX1	NP_066363.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..140
		AAA_11	597..1038	CDD:289831	109/655 (17%)
		AAA_19	604..>667	CDD:289986	20/155 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	796..819		8/43 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	876..896		5/22 (23%)
		DNA2	<903..1254	CDD:224037	100/452 (22%)
		AAA_12	1051..1234	CDD:289832	56/234 (24%)
		NF-X1-zinc-finger	1372..1417	CDD:100116
		NF-X1-zinc-finger	1461..1505	CDD:100116
		LELP1	<1498..1562	CDD:291701
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810