DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment armi and helz2b

DIOPT Version :9

Sequence 1:	NP_001014556.1	Gene:	armi / 38427	FlyBaseID:	FBgn0041164	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	XP_699251.2	Gene:	helz2b / 570654	ZFINID:	ZDB-GENE-070912-617	Length:	2781	Species:	Danio rerio

Alignment Length:	957	Identity:	214/957 - (22%)
Similarity:	375/957 - (39%)	Gaps:	252/957 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   341 LWQKESVSLKLTNNLNRT------LRLESITVCNDSESQLSVVSPL------ESKEISSGSEITV 393
            |.:...:..|.|....|:      |::|:..|.:.|:|..:.:.|:      |.:...|..:::|
Zfish   185 LQEDNEIRWKFTITTERSLAHVALLKVENGAVFSLSDSLRNTIPPITHIAGHELRSSQSTYQLSV 249

  Fly   394 TF-----EIHTQFLGEAIEKYVLNFDL-------LKVR--RVFTVIVCKTKEEVAEAEKRMIAAE 444
            :|     .::.|:|       |.:||:       ||||  :.|.|    ..||..|:|    .||
Zfish   250 SFLSFHPGVYEQWL-------VFDFDMRPVLLRKLKVRVGQQFLV----QPEEAEESE----CAE 299

  Fly   445 ALMAPGRNSQERSRFYANQVWCNKVDVIPGQQIVTKRRFVALRLGCFEVPKELRQICLTSERRQE 509
            .|              :|:.| |:     |.:::..          |...||..:..|:..:..:
Zfish   300 IL--------------SNERW-NR-----GNRVIVP----------FFARKEEDEQLLSKYKPPQ 334

  Fly   510 MIKAIEQHYSFLTEPLSIKTYMHRFRLLLHLEEIE----------C-FVNFRNY--DRDRAHFLR 561
            :......|... :.||..:.|..|....|..|||.          | .|:..|:  |.....:..
Zfish   335 LNLQFNPHADH-SLPLHRENYRERAHHFLFREEIAEEELISRLNVCGTVSLSNHLSDAMSLFYAA 398

  Fly   562 DGE-FLTLQIE-NLAERRPSLVI---GDTLRVINPWSDPDSQTTKS----YEGIIHKVLFDRILL 617
            .|: |..|::. :|....|..|:   |..:.::|..|...|.:.:.    ||..:.|.......|
Zfish   399 PGKLFANLKVSCSLTPDSPEGVVLKRGVQMALVNCKSTKASMSAEHRNHVYEAFVMKETVGEGHL 463

  Fly   618 KFHSSFQ-------EKYNGEDYRLEFYFSRYSFRKQHHAISKIVGVMG--EDF---LFPSKVTKR 670
            ....|.|       .|....:..::|..:|.||.:.|.||.::..:..  .||   ..|..:||:
Zfish   464 SLELSTQCVSELELRKETTCEMEVQFQLNRLSFCQIHQAIDRLPDLHNVLPDFSNCCVPVNLTKQ 528

  Fly   671 ENPQLDVYMKDDDMYLYDSKLEWYNQSLNSIQKRAVFNILRGEAEN----IPYVLFGPPGSGKTM 731
                                     ..||:.|:.|: |.:.|:.|:    .|.:::||.|:|||:
Zfish   529 -------------------------SQLNNKQQIAL-NFILGKCEDDKVAAPLLIYGPFGTGKTL 567

  Fly   732 TLIETLLQLVRNLPGARILVGTPSNSSADLV--------------TKRLIDSKALLQGDFIRLVS 782
            .|.....:|...... ::|:.|.:||||||.              |.:|:..||...|..|  ::
Zfish   568 CLASAAKELAHRSQN-KVLICTYTNSSADLYVREHFHPYIINGHPTLKLLRIKANKGGSAI--IA 629

  Fly   783 YNQVEKDLIPPEIMSYCATSDVGAVGSCEDKMMVTESGLKLRCQAKFIGTHRITISTCTTLGNFL 847
            .:.:.:        .||..|..|     :..::...|.|:         :|||.|:|.:...:..
Zfish   630 TDDITR--------KYCLCSRDG-----QSFILPARSDLE---------SHRIIITTTSIARHLH 672

  Fly   848 QLGFPAGHFTHVLFDEAGQCTEPETMVPIVMLTKKRSQVVLSGDPRQLQSIVTSRIASKMGFSIS 912
            :|..|.|.|||:|.|||.|..|.|.::.: .|..|.::|||:||..|:        |.|: ||::
Zfish   673 ELKLPKGFFTHILIDEASQMLEGEALMAL-GLADKHTRVVLAGDHMQM--------APKL-FSVT 727

  Fly   913 FLER----LLERSPYRKDLQRFPESSGYNPLVLTKLLY--NYRALPSIMSIYSRLFYDDELIPVL 971
            ..:|    ||.|      |..:.:....|....:::::  |||:...|:...|..||..:.|
Zfish   728 DDKRSEHTLLNR------LFHYYQDQSINIAKKSRIIFNENYRSTTEIVDFVSTYFYVSDGI--- 783

  Fly   972 SEKDSRESRLLSKLRCVFESEKDI---PQAHGTFFYGIIGENRQNN--DSPSWFNPQEVREVFLM 1031
                              ::..|:   |:.....|:.:.||...::  .|.||.|..||..|..|
Zfish   784 ------------------KARGDVHPHPRLKPLIFHHVRGECHLSSTITSTSWLNYAEVNSVVNM 830

  Fly  1032 TIALYR------ANVTADQIGIITPYQK----QVKMLRSMFIGTDVVMPKIGSVEEFQGQERDII 1086
            ...|..      .:....||.:::..|:    ::.:.|..|.|..|     .::...||::..:|
Zfish   831 VQVLLTDWPMEWGDKDPKQICVLSEGQQVAAIRIHLRRKGFYGVSV-----QNLANIQGKQFRVI 890

  Fly  1087 LISTVRSSEEILRMDARFSLGFVRCSKRLNVAVSRARAMMIIFGNPHLLA----VDECWRQLILF 1147
            :|:||.:.:::|::|:... .|....:.||.|::||::::::.|:...|.    ..:.||..|..
Zfish   891 IITTVHTRDKLLQLDSSCP-EFFDDIRALNTALTRAQSLVVVIGDAGALCCFGKCSKVWRAYIEH 954

  Fly  1148 CVKNNA----YFGCDLPQMVI-----NQKDEVPVCLETFVPSLNTTD 1185
            |:...:    :|..|:.|..:     .||.|....:||.|.....||
Zfish   955 CISKGSIKPDHFTRDVLQREVLEISKFQKTENVEKIETVVNLQAETD 1001

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
armi	NP_001014556.1	AAA_11	698..902	CDD:289831	62/221 (28%)
		AAA_19	720..768	CDD:289986	18/61 (30%)
		DNA2	<840..1155	CDD:224037	80/343 (23%)
		UvrD_C_2	909..1132	CDD:304668	52/243 (21%)
helz2b	XP_699251.2	AAA_11	530..725	CDD:289831	64/230 (28%)
		AAA	553..688	CDD:99707	41/159 (26%)
		DNA2	<647..959	CDD:224037	87/363 (24%)
		P-loop_NTPase	<662..>721	CDD:304359	23/67 (34%)
		UvrD_C_2	735..935	CDD:304668	49/232 (21%)
		RNB	1255..1482	CDD:279157
		RNB	1544..1845	CDD:214935
		AAA_11	2289..2532	CDD:289831
		AAA_19	2297..>2368	CDD:289986
		AAA_12	2543..2746	CDD:289832
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910