DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment armi and setx

DIOPT Version :9

Sequence 1:	NP_001014556.1	Gene:	armi / 38427	FlyBaseID:	FBgn0041164	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	XP_005161583.1	Gene:	setx / 562474	ZFINID:	ZDB-GENE-070402-1	Length:	2368	Species:	Danio rerio

Alignment Length:	798	Identity:	178/798 - (22%)
Similarity:	301/798 - (37%)	Gaps:	236/798 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   524 PLSIKTYMHRFRLLLHLEEIECFVNFRNYDRDRAHFLRDGEF-LTLQIENL----AERRPSLVIG 583
            |::..:|:..|..|..|..|..|....|      .:|::|.. |.|:::.:    .....|.:.|
Zfish  1524 PVNFSSYLEYFNTLYPLLLINAFEEMAN------EWLKEGRVKLYLKVQGIEYSNRTASASFIAG 1582

  Fly   584 DT----LRVINPWSD-------PDSQTTKSYEGIIHKVLFDRILLKFHSSFQEKYNGEDYRLEF- 636
            .:    ::.|.|..|       ||:  |.:|.                   |::.|..|....|
Zfish  1583 LSQECDVKQIYPKEDDLVLLWLPDN--TGAYA-------------------QDEPNFHDLHPHFG 1626

  Fly   637 YFSR-----------------------YSFRKQHHAISKIVGVMGEDFL-FPSKVTKRENPQLDV 677
            |.||                       .|.......:.::||.:...|. |.:....|..|.|
Zfish  1627 YVSRSNVLNRTPGSRSTLNLTIQTRGNVSSVNSQPVLCEVVGSLISIFREFRALCLLRNGPML-- 1689

  Fly   678 YMKDDDMYLYDSKLEWYNQSL-----------NSIQKRAV---FNILRGEAENIPYVLF-GPPGS 727
                  ..|....:.::..||           |..|.||:   ..::..:.:...::|. ||||:
Zfish  1690 ------RPLLAPHVSFFTHSLDGPSDLDAPEFNRDQARAIACGIAMIHRKQKTPKFLLIHGPPGT 1748

  Fly   728 GKTMTLIETLLQL----------VRNLPG----ARILVGTPSNSSADLVTKRLIDSKALL----- 773
            ||:.|:...|.:|          |.||..    .|:|:..|||::.|.:.|::|    |:
Zfish  1749 GKSKTIGGLLYKLLSSATNSSATVGNLHSKSRRTRVLLCAPSNAAIDSLMKKVI----LIFKEKC 1809

  Fly   774 ------QG-----DFIRLVSYNQVEKDLIP---------------------------------PE 794
                  ||     :.:||.:...:.|.|.|                                 ..
Zfish  1810 RNINAPQGNCGDINLVRLGNERTISKSLKPFSLDHQTKARAQRAQQTVESDVHRRKEQLDQMIEN 1874

  Fly   795 IMSYCATSDVGAVGSCEDKMMVTES------------------GLKLRCQAKFIGTHRITISTCT 841
            :...||.:.   ..|.|.|.::.:.                  |.:...||..:....:...|.:
Zfish  1875 LSHQCAKTQ---KNSTEFKNLLEQKKQFLKEREGLSRQIKECRGRRQESQALVLQNAHVICCTLS 1936

  Fly   842 TLGNF-LQLGF-PAGH--FTHVLFDEAGQCTEPETMVPIVMLTKKRSQVVLSGDPRQLQSIVTSR 902
            |.|:. |:..| ..||  |:.|:.|||.|..|.||::|::.   :...|:|.|||.||...|.|:
Zfish  1937 TSGSIVLENAFRRLGHEPFSCVIIDEASQAKETETLIPMLY---RCPSVILVGDPNQLPPTVVSQ 1998

  Fly   903 IASKMGFSISFLERLLERSPYRKDLQRFPESSGYNPLVLTKLLYNYRALPSIMSIYSRLFYDDEL 967
            .|.:.||..|.:.||.      |.|.  |.:|...|::|  |...||..|.|....|:..|:..|
Zfish  1999 KAKEFGFDQSLMARLC------KSLH--PSNSKLPPILL--LSMQYRMHPDICEFPSKYIYNSAL 2053

  Fly   968 IPVLSEKDSRESRLLSKLRCVFESEKDIPQAHGTFFYGIIGENRQNNDSPSWFNPQEVREVFLMT 1032
                 :.|...::....|...|:..|...          :.:.|:..:..|:.|.:||..|.|:.
Zfish  2054 -----KNDCETAQKRCSLSWPFKPYKVFD----------VMDGRETKERDSFINHKEVSLVGLLL 2103

  Fly  1033 IALYRANVTADQIGIITPYQKQ----VKMLRSMFIGTDVVMPKIGSVEEFQGQERDIILISTVRS 1093
            ..|.:..  |.::|:||||..|    :..:::..|...:.: ::.:|:.|||:|.|.|::|.||:
Zfish  2104 KLLCKEQ--AVRVGVITPYNAQKHRILDAIKTSGINKQLQV-EVDTVDGFQGREMDCIIVSCVRA 2165

  Fly  1094 SEEILRMDARFSLGFVRCSKRLNVAVSRARAMMIIFGNPHLLAVDECW---------RQLILFCV 1149
            |.|:      .|:|||...:|:||.::||:..:.|.|:...|.....|         |:.|:..:
Zfish  2166 SSEM------GSIGFVGNRQRMNVTITRAKFSLFILGHLRTLREQSDWGALIEDAGRRECIINTM 2224

  Fly  1150 KNNAYFGCDLPQMVINQK 1167
            :.|  |..|: :.::.||
Zfish  2225 QKN--FESDV-KKIVKQK 2239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
armi	NP_001014556.1	AAA_11	698..902	CDD:289831	67/303 (22%)
		AAA_19	720..768	CDD:289986	20/62 (32%)
		DNA2	<840..1155	CDD:224037	93/331 (28%)
		UvrD_C_2	909..1132	CDD:304668	61/226 (27%)
setx	XP_005161583.1	SEN1_N	37..>322	CDD:289496
		AAA_11	1714..1998	CDD:289831	66/293 (23%)
		AAA_12	2005..2197	CDD:289832	60/225 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574392
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148890at33208
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.840