DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment armi and mov10b.2

DIOPT Version :9

Sequence 1:	NP_001014556.1	Gene:	armi / 38427	FlyBaseID:	FBgn0041164	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	NP_001037805.1	Gene:	mov10b.2 / 555950	ZFINID:	ZDB-GENE-060526-371	Length:	1015	Species:	Danio rerio

Alignment Length:	1146	Identity:	316/1146 - (27%)
Similarity:	523/1146 - (45%)	Gaps:	236/1146 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 YLTFTTGEAMRVVKVKSILEHSWEDTSQKEIEKAVDNLKNEKPTFFNTETRSVLGLISQRLASSI 183
            ||:..   |:|.:.:..|  ...|:|:::.|..     :|.....:|||.|...|.:.
Zfish     9 YLSIA---AVRTIGLDFI--EMLEETNRRSISD-----RNTLTDIYNTEFRDRDGGVK------- 56

  Fly   184 DVETEYGQLTVELDNIEMNFIPTNGDRVRLECNIQL---DDGFVDKQ----------GEILEVTK 235
              :..:.::...|.|.....:...| ||....|::.   |..|..::          |.:..||
Zfish    57 --DPNFSRVLYALRNANKARLSRTG-RVYFNTNVRTGLHDQWFRPRRRQQNQANATPGNVSSVT- 117

  Fly   236 LFPTRIQEGEKCIVERVYVHMVVLGPET----------YILK----TD----------LPTGTDL 276
              |:. .:|..|             ||:          |||:    ||          :...::|
Zfish   118 --PSS-DQGPSC-------------PESGVRARRKLVKYILQRLNTTDRSHFIADKWGVRVSSEL 166

  Fly   277 HLGDIVLADLIECQYSKFTRRAIKITPLEKNFGATKLTQQSSMGSSGSGKAVTVTGVNRFITAEL 341
            ::.|                ..|:|:..|......||..:::     ..:||..|    :.||..
Zfish   167 YIED----------------GKIRISVDEAEVYELKLFVENT-----GQEAVYFT----YYTALC 206

  Fly   342 WQKESV---SLKLTNNLNRTLRLESITVCNDSESQLSVVSPLESKEISSGSEITVTFEIHTQFLG 403
            |.:...   |.|:|.  |..||||                |.|.            :|:..:|..
Zfish   207 WLQYFTLEDSRKVTR--NNPLRLE----------------PREK------------YEVIVRFKS 241

  Fly   404 EAIEKY--VLNFDLLK----VRRVFTVIVCKTKEEVAEAEKRMIAAEALMAPGRNSQERSRFYAN 462
            ..:..|  .|.|:..|    ..|.|.::      ...|||.|...| ||:.|....:......:.
Zfish   242 SHVGVYSATLAFEFKKNTQPTTRSFHIV------RFIEAEYRSKLA-ALLGPTEPYKPLRLNISE 299

  Fly   463 QVWCNKVDVIPGQQIVTKRRFVALRLGCFEVPKE-------LRQICLTSERRQEMIKAIEQHYSF 520
            ...|...:..|....:.......|.||.:..|.:       |::.| :|...:..:|.::   |.
Zfish   300 PENCIIDEGFPPDGYLQNFLVNVLPLGKYIPPPDTTILAELLKEDC-SSRIFRGKLKDLQ---SL 360

  Fly   521 LTEPLSIKTYMHRFRLLLHLEEIECFVNFRNYDRDRA--HFLRDGEFLTLQIENLAERRPSLVIG 583
            |..||:...|..||.|||:|||.:..|:.:.|::|..  |..||...:.|.:..::|.|||::.|
Zfish   361 LQSPLTFDNYAERFDLLLYLEECQMHVDIKRYNKDSVTLHRDRDKRLMGLNLPGVSENRPSVLRG 425

  Fly   584 DTLRVINPWSDPDSQTTKSYEGIIHKVLFDRILLKFHSSF-QEKY-NGEDYRLEFYFSRYSFRKQ 646
            |.|.:........|..|| |:|.:|:|..|::.|.....| ::.| :...:|:||..:|...|.|
Zfish   426 DHLLLTKSEEVTFSNVTK-YKGYVHRVELDQVKLGLSKRFLKDVYIDKMKFRVEFTVNRIPVRLQ 489

  Fly   647 HHAISKIVGVMGEDFLFPSKVTKRENPQLDVYMKDDDMYLYDSKLEWYNQSLNSIQKRAVFNILR 711
            |.|:...|....:|.||| ..::..||     :....:.|:|.|||:     |..|..||.||:.
Zfish   490 HRAVHMAVQHNLKDVLFP-MASRSLNP-----VSPPALRLFDRKLEY-----NFQQYSAVCNIVA 543

  Fly   712 GEAENIPYVLFGPPGSGKTMTLIETLLQLVRNLPGARILVGTPSNSSADLVTKRLIDSKALLQGD 776
            |.::..||::|||||:|||:|::|.:.|:.:|:|.|.||...||||:||.:.::||.|:.:....
Zfish   544 GTSKPAPYLVFGPPGTGKTVTIVEAIKQVEKNIPDAYILACAPSNSAADQLCEKLITSEHVDAHK 608

  Fly   777 FIRLVSYNQVEKDLIPPEIMSYCATSDVGAVGSCEDKMMVTESGLKLRCQAKFIGTHRITISTCT 841
            ..||.:.::.:||:  |:|:              :|...|.|..:...|:...: :::|.|.|..
Zfish   609 IYRLYASSRNQKDI--PKIL--------------KDNCNVDEEMIDFPCKEDLM-SYKILICTLV 656

  Fly   842 TLGNFLQLGFPAGHFTHVLFDEAGQCTEPETMVPIV-MLTKKRSQVVLSGDPRQLQSIVTSRIAS 905
            |.|..:..||...||||...||||...|.||::.:. :|..::.|:||:|||:||..|:.|.:|.
Zfish   657 TAGRLVTGGFSEDHFTHNFVDEAGHAVESETIISVAGLLNAEKGQLVLAGDPKQLGPILRSPLAI 721

  Fly   906 KMGFSISFLERLLERSPY--RKDLQRFPESSGYNPLVLTKLLYNYRALPSIMSIYSRLFYDDELI 968
            ..|..:|.||||:.::..  |.|::       ::...::||:.|||:.|.|:.:.:|||||.||.
Zfish   722 NHGLDVSLLERLMTQNDLYKRGDVE-------FDNRYVSKLIMNYRSHPYILEVPNRLFYDGELK 779

  Fly   969 PVLSEKDSRESRLLSKLRCVFE--SEKDIPQAHGTFFYGIIGENRQNNDSPSWFNPQEVREV--F 1029
            ....|..|.:       .|::|  ..|..|    ..|:|:.|::.:.::|||:||..|:..:  :
Zfish   780 ACADEISSNQ-------YCMWEHLPSKGFP----VIFHGVPGKDERESNSPSFFNIYEINILVDY 833

  Fly  1030 LMTIALYR-----ANVTADQIGIITPYQKQVKMLRSM---------FIGTDVVMPKIGSVEEFQG 1080
            |..:.|.:     :.:....||||.||:|||:.::..         ::|.|.:  |:||||||||
Zfish   834 LKKLLLTQPKKGISRIFPKDIGIIAPYRKQVEKIKRAIDADKDFQDYMGIDNL--KVGSVEEFQG 896

  Fly  1081 QERDIILISTVRSSEEILRMDARFSLGFVRCSKRLNVAVSRARAMMIIFGNPHLLAVDECWRQLI 1145
            |||.:|::||||||.:.:.:|..|::||::..||.||||:||::::|:.|||.:|..||.|.:.|
Zfish   897 QERKVIMVSTVRSSVKYISLDETFNIGFLKNEKRFNVAVTRAKSLLIMVGNPMILRTDESWGRFI 961

  Fly  1146 LFCVKNNAYFGCDLPQMVINQKDEVPVCLETFVPSLNTTDD 1186
            .||::...|.|..:..  :.:.|:|    |:.:.:||..|:
Zfish   962 DFCLERGGYTGISITS--VERIDDV----ESRLLALNIQDE 996

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
armi	NP_001014556.1	AAA_11	698..902	CDD:289831	72/204 (35%)
		AAA_19	720..768	CDD:289986	23/47 (49%)
		DNA2	<840..1155	CDD:224037	119/335 (36%)
		UvrD_C_2	909..1132	CDD:304668	82/242 (34%)
mov10b.2	NP_001037805.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	94..130		9/52 (17%)
		MYCBPAP	<189..>262	CDD:291319	22/111 (20%)
		AAA_11	552..718	CDD:289831	63/182 (35%)
		P-loop_NTPase	552..>714	CDD:304359	62/178 (35%)
		DNA2	<642..983	CDD:224037	124/363 (34%)
		DEAG box	677..680		2/2 (100%)
		AAA_12	725..948	CDD:289832	82/242 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I4307
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	370	1.000	Inparanoid score	I2086
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148890at33208
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	1	1.000	-	-		otm25596
orthoMCL	1	0.900	-	-		OOG6_101029
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1732
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.770