DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment armi and MOV10

DIOPT Version :9

Sequence 1:	NP_001014556.1	Gene:	armi / 38427	FlyBaseID:	FBgn0041164	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	NP_001123551.1	Gene:	MOV10 / 4343	HGNCID:	7200	Length:	1003	Species:	Homo sapiens

Alignment Length:	930	Identity:	289/930 - (31%)
Similarity:	442/930 - (47%)	Gaps:	196/930 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   325 GKAVTVTGVNR------FITAELWQKESVSLKLTNNLNRTLRLESI-TVC--------NDSESQL 374
            |..|.|.|.:.      .|..:|.:||.::|:|.|...:::.|..: .:|        |:.:...
Human   123 GVDVEVQGPHEARDGQLLIRLDLNRKEVLTLRLRNGGTQSVTLTHLFPLCRTPQFAFYNEDQELP 187

  Fly   375 SVVSPLESKEI------------------------SSGSEITVTFEIHTQFLGEAIEKYVLNFDL 415
            ..:.|.|..|:                        .||||...||.| .:||
Human   188 CPLGPGECYELHVHCKTSFVGYFPATVLWELLGPGESGSEGAGTFYI-ARFL------------- 238

  Fly   416 LKVRRVFTVIVCKTKEEVAEAEKRMIAAEALMAPGRNSQERSRFYANQVWCNKVDVIPGQQIVTK 480
                             .|.|...:.|....|.|.:    |:|...|.|..|:::  .|::....
Human   239 -----------------AAVAHSPLAAQLKPMTPFK----RTRITGNPVVTNRIE--EGERPDRA 280

  Fly   481 RRF---VALRLGCFEVPKELRQICLTSERRQEMIKAIEQHYSFLTEPLSI-------------KT 529
            :.:   :::.||.:..|..|||          ::..:.|..|..|.|..|             :.
Human   281 KGYDLELSMALGTYYPPPRLRQ----------LLPMLLQGTSIFTAPKEIAEIKAQLETALKWRN 335

  Fly   530 YMHRFRLLLHLEEIECFVNFRNYDRDRAHFLRD-----GEFLTLQIENLAERRPSLVIGDTLRVI 589
            |..:.||||||||::...:.|:||.:......|     ...|||::..:.|.|||::.||.|..:
Human   336 YEVKLRLLLHLEELQMEHDIRHYDLESVPMTWDPVDQNPRLLTLEVPGVTESRPSVLRGDHLFAL 400

  Fly   590 NPWSDPDSQTTKSYEGIIHKVLFDRILLKFHSSFQEKY-NGEDYRLEFYFSRYSFRKQHHAISKI 653
            .. |:...:...:|:|.:|||..||:.|.|..|...:: :|..:::.|.|:|...|.||.|:.
Human   401 LS-SETHQEDPITYKGFVHKVELDRVKLSFSMSLLSRFVDGLTFKVNFTFNRQPLRVQHRALE-- 462

  Fly   654 VGVMGEDFLFPS--KVTKRENPQL--DVYMKDDDMYLYDSKLEWYNQSLNSIQKRAVFNILRGEA 714
              :.|...|:|.  .|..|:.|.|  ||.:|     |||..||     .|..|.:|:.:|:.|..
Human   463 --LTGRWLLWPMLFPVAPRDVPLLPSDVKLK-----LYDRSLE-----SNPEQLQAMRHIVTGTT 515

  Fly   715 ENIPYVLFGPPGSGKTMTLIETLLQLVRNLPGARILVGTPSNSSADLVTKRLIDSKALLQGDFIR 779
            ...||::|||||:|||:||:|.:.|:|::||.|.||...||||.|||:.:||   :..|.....|
Human   516 RPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACAPSNSGADLLCQRL---RVHLPSSIYR 577

  Fly   780 LVSYNQVEKDL-IPPEIMSYCATSDVGAVGSCEDKMMVTESGLKLRCQAKFIGTHRITISTCTTL 843
            |::   ..:|: :.||.:..|...|             .:.|..:....|.:..:|:.|:|..|.
Human   578 LLA---PSRDIRMVPEDIKPCCNWD-------------AKKGEYVFPAKKKLQEYRVLITTLITA 626

  Fly   844 GNFLQLGFPAGHFTHVLFDEAGQCTEPETMVPIVMLTKKR------SQVVLSGDPRQLQSIVTSR 902
            |..:...||..||||:..||||.|.|||::|.|..|.:.:      .|:||:||||||..::.|.
Human   627 GRLVSAQFPIDHFTHIFIDEAGHCMEPESLVAIAGLMEVKETGDPGGQLVLAGDPRQLGPVLRSP 691

  Fly   903 IASKMGFSISFLERLLE-RSPYRKDLQRFPESSGYNPLVLTKLLYNYRALPSIMSIYSRLFYDDE 966
            :..|.|...|.|||||. .|.|:|.    |:  ||:|..:||||.|||:.|:|:.|.::|:|:.|
Human   692 LTQKHGLGYSLLERLLTYNSLYKKG----PD--GYDPQFITKLLRNYRSHPTILDIPNQLYYEGE 750

  Fly   967 LIPVLSEKDSRESRLLSKLRCVFESEKDIP-QAHGTFFYGIIGENRQNNDSPSWFNPQEVREVFL 1030
            | ...::...||.         |.....:| |.....|:|::|::.:..:|||:|||:|.
Human   751 L-QACADVVDRER---------FCRWAGLPRQGFPIIFHGVMGKDEREGNSPSFFNPEEA----- 800

  Fly  1031 MTIALY------------RANVTADQIGIITPYQKQVKMLRSMFI-------GTDVVMP-KIGSV 1075
            .|:..|            :|.::...:|:|:||:|||:.:|....       |.|.:.. |:|||
Human   801 ATVTSYLKLLLAPSSKKGKARLSPRSVGVISPYRKQVEKIRYCITKLDRELRGLDDIKDLKVGSV 865

  Fly  1076 EEFQGQERDIILISTVRSSEEILRMDARFSLGFVRCSKRLNVAVSRARAMMIIFGNPHLLAVDEC 1140
            ||||||||.:|||||||||:..:::|..|:|||::..||.||||:||:|::||.|||.||..|..
Human   866 EEFQGQERSVILISTVRSSQSFVQLDLDFNLGFLKNPKRFNVAVTRAKALLIIVGNPLLLGHDPD 930

  Fly  1141 WRQLILFCVKNNAYFGCDLP 1160
            |:..:.||.:|..|.||..|
Human   931 WKVFLEFCKENGGYTGCPFP 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
armi	NP_001014556.1	AAA_11	698..902	CDD:289831	75/210 (36%)
		AAA_19	720..768	CDD:289986	27/47 (57%)
		DNA2	<840..1155	CDD:224037	133/342 (39%)
		UvrD_C_2	909..1132	CDD:304668	93/244 (38%)
MOV10	NP_001123551.1	DEXXQc_Helz-like	498..733	CDD:350796	97/264 (37%)
		DEAG box	645..648		2/2 (100%)
		SF1_C_Upf1	734..939	CDD:350195	80/219 (37%)
		Interaction with AGO2 and APOBEC3G. /evidence=ECO:0000269\|PubMed:22791714	921..965		13/30 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	966..1003
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	140	1.000	Domainoid score	I4762
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4684
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148890at33208
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	1	1.000	-	-		otm42013
orthoMCL	1	0.900	-	-		OOG6_101029
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9180
SonicParanoid	1	1.000	-	-		X1732
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.700