DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment armi and Setx

DIOPT Version :9

Sequence 1:	NP_001014556.1	Gene:	armi / 38427	FlyBaseID:	FBgn0041164	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	XP_006233948.1	Gene:	Setx / 362096	RGDID:	1565575	Length:	2702	Species:	Rattus norvegicus

Alignment Length:	1406	Identity:	284/1406 - (20%)
Similarity:	473/1406 - (33%)	Gaps:	505/1406 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KFFTNPDRNREDILESLDRENSFLDQKLMEE--------------KMDQQLKANPNEINGVLSNK 57
            |..|:.|...:.::.|...:....|.|..:.              ..|.....||.....:..:.
  Rat  1330 KLLTSQDLQFQRLMRSRSHQKRDFDYKNTDSVRAVSRVVQGSDVLAADSDEPDNPGGSEPLAISS 1394

  Fly    58 IAELTHG-LSEMDVSKESS-------------CTARKGVITSLDGDRGVIDKDVLFETKVAEDII 108
            ..:|..| ||:.:|::.:|             |.:|  |::      |.:..|||..: .:||
  Rat  1395 EKQLAKGTLSKAEVAEAASGPWGTGITCLVNQCESR--VLS------GGVPTDVLMGS-ASED-- 1448

  Fly   109 LDLHVGCVVEYLTFTTGEAMRVVKVKSILEHSWEDTSQKEIEKAVDNLKNEKPTFFNTETRSVLG 173
               .||...  ||...||   |..|::....|..||...      |||
  Rat  1449 ---PVGGGA--LTVQVGE---VAAVRAAEPESSSDTDDD------DNL----------------- 1482

  Fly   174 LISQRLASSIDVETEYGQLTVELDNIEMNFIPTNGDRVRLECNIQLDDGFVDKQGEILEVTK--- 235
            .::|.....:|       |..:|:|.:. .|..:.|      .:|.:|.....|.|.|.:.|
  Rat  1483 FLTQHDPQDMD-------LCSQLENSKA-IIVAHKD------TVQREDSLSRPQLESLSIIKCKY 1533

  Fly   236 --LFPTRIQEGEKC------------IVERVYVHMVVLGPETYILKTDLPTGTDLHLGDIV--LA 284
              ...|...:||.|            :..:.       |....:.::..||.|.:......  .|
  Rat  1534 KDCVETTKNQGEYCPKHSEAKAADDDVFRKP-------GLPLSVARSSRPTTTKIFSSSSASRTA 1591

  Fly   285 DLIECQYSKFTRRAIKITPLEKNFGA---TKLTQQSSMGSSGS-GKAVTVTGVNRFITAELWQKE 345
            :|.:...|...:.|:|    .|:.||   .|:|..||:||... .:..::..:..|.|.....|:
  Rat  1592 NLSKSLESTTLQSALK----NKSSGAQSNLKMTPSSSLGSQKPVAEVKSLCNIFHFQTPSSSSKQ 1652

  Fly   346 SVSLKLTNNLNRTLRLESITVCNDSESQLSVVSPLESKEISSGSEITVTFEIHTQFLGEAIE-KY 409
              |.|.|.:.||..         .:.|.:.::.|.:|              |...|:.|.:: ||
  Rat  1653 --SYKFTFSENRPA---------SAASSVDILLPSQS--------------IFDTFIKEVLKWKY 1692

  Fly   410 --VLNFDLLKVRRVFTVIVCKTKEEVAEAEKRMI---------------------AAEALMAPGR 451
              .||||           .|.....:.::..|.:                     |.|.:.....
  Rat  1693 QMFLNFD-----------KCGAPTSLCQSISRPVPVRFQDCAEYFNVFLPLIILNAFETVAQEWL 1746

  Fly   452 NSQERSRFYANQVWCNKVDVIPGQQ-------IVTKRRFVALRLGCFEVPKELRQICLTSERRQE 509
            ||..:..||  |:...|   .|...       |..:...:|.:|.    |||...:.|..|:
  Rat  1747 NSPNKENFY--QLHLRK---FPADYKKYWEFLIYLEESELAKQLH----PKENDLVFLVPEK--- 1799

  Fly   510 MIKAIEQHYSFLTEPLSIKT-------YMHRFRLLLHLEEIECFVNFRNYDRDRAHFLRDGE--- 564
              |.:::|        |::.       |:|:||                    |...:|.|:
  Rat  1800 --KYMDRH--------SVQDRSHYYCGYVHKFR--------------------RTSVMRSGKTEC 1834

  Fly   565 FLTLQIENLAERRPSLVIGDTLRVINPWSDPDSQTTKSYEGIIHKVLFDRILLKFHSSFQEKYNG 629
            .|.:|.:   :..|:.|                           |.|...|::....:.|.|...
  Rat  1835 SLCIQTQ---DNMPASV---------------------------KELTKCIVISSLVTTQRKLKA 1869

  Fly   630 EDYRLEFYFSRYSFRKQHHAISKIVGVMGEDFLFPSKVTKRENPQLDVYMKDDDMYLYDSKLEWY 694
                    .|..|.|.|  ....::.....||.....:| ..:.::..|:||
  Rat  1870 --------MSLLSGRNQ--LARAVLNPNPMDFCTKDLLT-TTSERIIAYLKD------------- 1910

  Fly   695 NQSLNSIQKRAVFNILRGEAENIPYV-----LFGPPGSGKTMTLIETLLQLV------------- 741
               .|..||:|: .......::.|.|     :.||||:||:.|::..|.:|:
  Rat  1911 ---FNEDQKKAI-ETAYAMVKHSPSVAKICLIHGPPGTGKSKTIVGLLYRLLTESQRKGHSDENF 1971

  Fly   742 -RNLPGARILVGTPSNSSADLVTKRLI--------DSKALLQ--GD--FIRL------------- 780
             ..:...|:||..|||::.|.:.|::|        |.|..|.  ||  .:||
  Rat  1972 NAKIKQNRVLVCAPSNAAVDELMKKIILEFKEKCKDKKNPLGNCGDINLVRLGPEKSINTEVLKF 2036

  Fly   781 -----VSYNQVEKDLIPPEIMSYCATSDV-----------------G------------AVGSCE 811
                 ||: :::||| |..|.......::                 |            .:.|.|
  Rat  2037 SLDSQVSH-RMKKDL-PSHIQEMLRRKEILDAQLDELSRQRALCRGGREMQRQELDEHIVIVSKE 2099

  Fly   812 DKMMVTE----SGLKLRCQAKFIGTHRITISTCTTLGNFL-------QLGFPAGHFTHVLFDEAG 865
            .:.:.::    .|...|.|...|....:...|.:|.|..|       |.|.|   |:.|:.||||
  Rat  2100 RQELASKIKEVQGRPQRAQNTIILESHVICCTLSTSGGLLLESAFRGQGGVP---FSCVIVDEAG 2161

  Fly   866 QCTEPETMVPIVMLTKKRSQVVLSGDPRQLQSIVTSRIASKMGFSISFLER---LLERSPYRKDL 927
            |..|.||:.|::   .:.:::||.|||:||...|.|..|.:.|:..|.:.|   |||.:..:..:
  Rat  2162 QSCEVETLSPLI---HRCNKLVLVGDPKQLPPTVISMKAQEYGYDQSMMARFCKLLEENVEQNMI 2223

  Fly   928 QRFPESSGYNPLVLTKLLYNYRALPSIMSIYSRLFYDDELIPVLSEKDSRESRLLSKLRC----- 987
            .|.|         :.:|...||..|.|....|...|:         |:.:.:||...:||
  Rat  2224 GRLP---------VLQLTIQYRMHPDICLFPSNYVYN---------KNLKTNRLTETIRCSSEWP 2270

  Fly   988 -----VFESEKDIPQAHGTFFYGIIGENRQNNDSPSWFNPQEVREV--FLMTIALYRANVTADQI 1045
                 ||:                :|:..:..|:.|:.|.||::.|  .:..|...|.:::...|
  Rat  2271 FQPYLVFD----------------VGDGSEQRDNDSYINVQEIKLVMEIIKLIKEKRKDISFRNI 2319

  Fly  1046 GIITPYQKQVKM--------------LRSMFIG-------------------------------- 1064
            ||||.|:.|..|              |:.:.:|
  Rat  2320 GIITHYKAQKTMIQKDLEKEFDKKGLLQPIMMGESRQQDSEASKQQQKSSECMHASDELDSSTVT 2384

  Fly  1065 -----------TDVVMPKIGSVEEFQGQERDIILISTVRSSEEILRMDARFSLGFVRCSKRLNVA 1118
                       |.....::.:|:.|||:::|.|:::.||:|.      .:.|:||:...:||||.
  Rat  2385 QSGISSLENGATHTGPAEVDTVDAFQGRQKDCIIVTCVRASA------VQGSIGFLASLQRLNVT 2443

  Fly  1119 VSRARAMMIIFGNPHLLAVDECWRQLILFCVKNNAYF-GCD 1158
            ::||:..:.|.|:...|..::.|.:||....|..|.. .||
  Rat  2444 ITRAKYSLFILGHLRTLMENQHWYELIQDAQKRGAIIKTCD 2484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
armi	NP_001014556.1	AAA_11	698..902	CDD:289831	71/292 (24%)
		AAA_19	720..768	CDD:289986	19/74 (26%)
		DNA2	<840..1155	CDD:224037	95/393 (24%)
		UvrD_C_2	909..1132	CDD:304668	61/294 (21%)
Setx	XP_006233948.1	SEN1_N	37..>356	CDD:289496
		AAA_11	1910..2195	CDD:289831	72/309 (23%)
		AAA_19	1934..>1997	CDD:289986	17/62 (27%)
		AAA_12	2202..2456	CDD:289832	60/293 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148890at33208
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920