Protein Alignment armi and Dna2

DIOPT Version :10

• Sequence 1: NP_647816.2
• Gene: armi / 38427
• FlyBaseID: FBgn0041164
• Length: 1188
• Species: Drosophila melanogaster
• Sequence 2: NP_796346.2
• Gene: Dna2 / 327762
• MGIID: 2443732
• Length: 1062
• Species: Mus musculus
• Alignment Length: 1177
• Identity: 256/1177 - (21%)
• Similarity: 446/1177 - (37%)
• Gaps: 351/1177 - (29%)

  Fly   152 AVDNLKNEKPTFFNTETRSVLGLISQRLASSIDVETEYGQLTVELDNIEMNFIPTN-GDRVRLE- 214
            ||:..:||:            |...:||..:...:.|:..|.: |.| ..:.:|.. ||.|.||
Mouse    52 AVETSQNER------------GAEEKRLHVTASQDREHEVLCI-LRN-GWSSVPVEPGDIVHLEG 102

  Fly   215 -CNIQ---LDDGFVDKQGEILEVTKLFP------TRIQEGEKCIVERVYVHMVVLG--PETYILK 267
             |..:   :||.|    |..:    |:|      |.:....:|: .|..:.....|  |.|
Mouse   103 DCTSEPWIIDDDF----GYFI----LYPDMMISGTSVASSIRCL-RRAVLSETFRGSDPAT---- 154

  Fly   268 TDLPTGTDLH---------------LGDIVLADLIE------------------CQ-------YS 292
            ..:..||.||               |.::.|..|.|                  |:       :|
Mouse   155 RQMLIGTILHEVFQKAISESFAPERLQELALQTLREVRHLKEMYRLNLSQDEILCEVEEYLPSFS 219

  Fly   293 KFTRRAIKITPLEKNFGATKLTQ-QSSMGSSGSGKAVTVTGVNRFITAELWQKESV---SLKLTN 353
            |:....::..|      :::..| |.|:.|.||.::   :..|..:...|..:||:   ...|..
Mouse   220 KWAEDFMRKGP------SSEFPQMQLSLPSDGSNRS---SPCNIEVVKSLDIEESIWSPRFGLKG 275

  Fly   354 NLNRTLRLESITVCNDSESQLSVVSPL------ESKEISSGSEITVTFEIHTQFLGEAIEKYVLN 412
            .::.|:   .:.:..|.:.:..|: ||      ||..|...|:: |.:.:.:|...|..|...|.
Mouse   276 KIDVTV---GVKIHRDCKMKYKVM-PLELKTGKESNSIEHRSQV-VLYTLLSQERREDPEAGWLL 335

  Fly   413 F-----------------DLLKVRRVFTVIVCKTKEEVAEAEKRMIAAEALMAPGRNSQERSRFY 460
            :                 :|||:|......:.......|..|:..::|    .|....:|::..|
Mouse   336 YLKTGQMYPVPANHLDKRELLKLRNWLAASLLHRVSRAAPGEEARLSA----LPQIIEEEKTCKY 396

  Fly   461 ANQV-----WCNKVD------VIPGQQIVTKRRFVALRLGCFEVPKELRQI-----------CLT 503
            .:|:     :...|:      .|| :.:::|            :.:|.|.:           ||.
Mouse   397 CSQIGNCALYSRAVEEQGDDASIP-EAMLSK------------IQEETRHLQLAHLKYFSLWCLM 448

  Fly   504 SERRQEMIKAIEQHYSFLTEPLSIKTYMHRFRLLLHLEEI-ECFVNF-RNYDRDRAHFLRDGEFL 566
            .....:.....:.|.|....|.|            .|||. .|..|. |.....|   :.||::|
Mouse   449 LTLESQSKDNRKTHQSIWLTPAS------------ELEESGNCVGNLVRTEPVSR---VCDGQYL 498

  Fly   567 -TLQIENLAERRPSLVIGDTLRVINPWSDPDSQTTKSYEGIIHKV-------LFDRILLKFHSSF 623
             ..|.:|......:|:.||  |:|  .|..:.:.....:|.:.|:       |.||.|....::
Mouse   499 HNFQRKNGPMPATNLMAGD--RII--LSGEERKLFALSKGYVKKMNKAAVTCLLDRNLSTLPAT- 558

  Fly   624 QEKYNGEDYRLEFYFSRYSFRKQHHA-ISKIVGVMGE--DFLFPSK------VTKRENPQLDVYM 679
                  ..:||:        |::.|. ||..:|.:.:  :...|||      :..|| ||...|:
Mouse   559 ------TVFRLD--------REERHGDISTPLGNLSKLMESTDPSKRLRELIIDFRE-PQFIAYL 608

  Fly   680 KDDDMYLYDSKLEWYN--QSLNSIQKRAVFNILRGEAENIPYVLF-GPPGSGKTMTLIETLLQLV 741
              ..:..:|:|....|  :.||..|::|:..:|..:    .|.|. |.||:|||    .|:..||
Mouse   609 --SSVLPHDAKDTVANILKGLNKPQRQAMKRVLLSK----DYTLIVGMPGTGKT----TTICALV 663

  Fly   742 RNLP--GARILVGTPSNSSADLVTKRLIDSKALLQGDFIRLVSYNQVEKDLIPPEIMSYCATSDV 804
            |.|.  |..:|:.:.::|:.|.:..:|...|.    .|:||...::|..|:........|.:..:
Mouse   664 RILSACGFSVLLTSYTHSAVDNILLKLAKFKV----GFLRLGQSHKVHPDIQKFTEEEICRSRSI 724

  Fly   805 GAVGSCEDKMMVTESGLKLRCQAKFIGTHRITISTCTTLGNFLQLGFPAGHFTHVLFDEAGQCTE 869
            .::...|:                ...:|.|..:||..:.:.:   |....|...:.|||.|.::
Mouse   725 ASLAHLEE----------------LYNSHPIVATTCMGINHPI---FSRKTFDFCIVDEASQISQ 770

  Fly   870 PETMVPIVMLTKKRSQVVLSGDPRQLQSIVTSRIASKMGFSISFLERLLERSPYRKDLQRFPESS 934
            |..:.|:..    ..:.||.||.:||..:|.:|.|..:|.|.|..:| |||
Mouse   771 PVCLGPLFF----SRRFVLVGDHQQLPPLVVNREARALGMSESLFKR-LER-------------- 816

  Fly   935 GYNPLVLTKLLYNYRALPSIMSIYSRLFYDDEL--------IPVLSEKDSRESRLLSKLRCVFES 991
              |...:.:|...||....|||:.::|.|..:|        ..||:..:.:::||..:|   :..
Mouse   817 --NESAVVQLTVQYRMNRKIMSLSNKLTYAGKLECGSDRVANAVLALPNLKDARLSLQL---YAD 876

  Fly   992 EKDIPQAHGTFFYGIIGENRQNNDSPSWF------------------NPQEVREVFLMTIALYRA 1038
            ..|.|...|..          ..|:|..|                  |..|.|.:..:|....:|
Mouse   877 YSDSPWLAGVL----------EPDNPVCFLNTDKVPAPEQVENGGVSNVTEARLIVFLTSTFIKA 931

  Fly  1039 NVTADQIGIITPYQKQVKMLRSMFIGTDVVMPKIGSVEEFQGQERDIILISTVRSSEEILRMDAR 1103
            ..:...||:|.||::|::::..:...:.|.|.::.:|:::||:::.:||:|.|||:|:
Mouse   932 GCSPSDIGVIAPYRQQLRIISDLLARSSVGMVEVNTVDKYQGRDKSLILVSFVRSNED------- 989

  Fly  1104 FSLG-FVRCSKRLNVAVSRARAMMIIFGN--------------PHLLAVDECWRQLILFCVKNNA 1153
            .:|| .::..:|||||::||:..:|:.|:              .||.|     .||||
Mouse   990 GTLGELLKDWRRLNVALTRAKHKLILLGSVSSLKRFPPLGTLFDHLNA-----EQLIL------- 1042

  Fly  1154 YFGCDLP 1160
                |||
Mouse  1043 ----DLP 1045

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
armi	NP_647816.2	DEXXQc_Mov10L1	697..949	CDD:350836	61/254 (24%)
		DNA2	<829..1148	CDD:440729	90/359 (25%)
Dna2	NP_796346.2	Nuclease activity. /evidence=ECO:0000250	82..520		97/500 (19%)
		DNA2_N-like	127..366	CDD:411722	47/257 (18%)
		Helicase activity. /evidence=ECO:0000250	521..1062		149/631 (24%)
		P-loop containing Nucleoside Triphosphate Hydrolases	572..>675	CDD:476819	33/113 (29%)
		DEXXQc_DNA2	626..829	CDD:350799	61/254 (24%)
		AAA_12	806..1020	CDD:463780	61/250 (24%)