DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment armi and Zgrf1

DIOPT Version :9

Sequence 1:	NP_001014556.1	Gene:	armi / 38427	FlyBaseID:	FBgn0041164	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	XP_006233356.1	Gene:	Zgrf1 / 310880	RGDID:	1305834	Length:	2031	Species:	Rattus norvegicus

Alignment Length:	1429	Identity:	286/1429 - (20%)
Similarity:	502/1429 - (35%)	Gaps:	450/1429 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 DRNREDILESLDRENSFLDQKLMEEKMDQQLKANPNEINGVLSNKI---AELTHGL---SEMDVS 71
            |||.|.:|..:  .:|.:..:|:....|.......:|.|..:|:.:   ..:.|.:   ||.|:|
  Rat   714 DRNDEWVLSPI--SSSDISGQLLSTTQDHSEHHELDEFNTQVSSSLFYPVGIKHPIYRDSEEDIS 776

  Fly    72 KESSCTARKGVITSLDGDRGVID----KDVLFETKVAEDIILDLHVGCVVEYLTF--------TT 124
            :....    |.|.||..:...::    .:..:.|......:|:     |:..::|        |.
  Rat   777 ESKEL----GRIRSLSCNHFKVETTQRNEQSWATYKNSSELLE-----VINNISFLKSRPEHGTA 832

  Fly   125 GEAMRVVKVKSILEHSWEDTSQKEIE-KAVDNLKNEKPTFFNTETRSVLGLISQRLASSIDVETE 188
            .|.:.|||.|.:..|..:.:...::. ||               .||...::|..|   :|...|
  Rat   833 LENLAVVKEKHVFPHEVQHSRGPDVSPKA---------------RRSPATVVSHAL---LDCPHE 879

  Fly   189 Y--GQLTVELDNIEMNFIPTNGDRVR-----LEC-----NIQLDDGFVDK------------QGE 229
            :  .|..||....::....|:|..||     |.|     :|:.|....|.            |.:
  Rat   880 HRASQQPVEFQGHQVKGSATSGVMVRGHSLQLGCSQFPDSIEYDSFLTDPCVWTPELPSTCVQSD 944

  Fly   230 ILEV-------------TKLFPTRIQEGEKCIVERVYVHMVVLGPETYILKTDLPTGTDLHLGDI 281
            .|:|             |..|.||.::.|....|.                 .|.|.|...|.:|
  Rat   945 FLQVISPEKISAFSPAPTFSFNTRSEDSELEFSEE-----------------SLKTRTFPGLKNI 992

  Fly   282 VLADLIECQYSKFTRRA-IKITPLEKNFGATKLTQQSSM------GSSGSGKAVTVTGVNRFITA 339
            ...|....|...|...| :....|..:.|...|...|.|      ..|||.:            .
  Rat   993 GFQDNKNFQRFPFLSGASVPFVTLPPDDGPAVLDSCSFMIDDDTREPSGSSR------------L 1045

  Fly   340 ELWQKESVSLKL-----------------TNNLNRTLRLESITVCNDSESQ--LSVVSPLESKEI 385
            .|.::..:|..|                 ::..::.|:.::.:.||.:...  .|.|:...|.|.
  Rat  1046 NLCEESGLSFDLGLEDQDGIPRDVLLLPKSSTQSKWLKYQNPSHCNSAALNRIASEVTEDLSAEA 1110

  Fly   386 SSGSEITVTFE-------IHTQFLGEAIEKYVLNF---DLLKVRRVFTVIVCKTKEEVAEAEKRM 440
            .||...:.|.|       :|.|.:...:.:...:|   ||:..::..::.:.:|..
  Rat  1111 VSGLHFSHTSESESSVDPVHLQMIKGMLYQQQQDFTSQDLVSRQKALSLNLNQTSR--------- 1166

  Fly   441 IAAEALMAPGRNSQERSRFYANQVWCNKVDVIP-GQQIVT---KRRFVALRLGCFEVPKELRQIC 501
             ..|...|.|.::....|....|...|.....| ||:|::   .:|.|.:. ..|:.|...|||.
  Rat  1167 -TGELRTALGSSASSNCRVRDGQEINNSDLCFPNGQKILSAYLPQRQVHIP-AVFQSPAHYRQIF 1229

  Fly   502 LTSERRQEMIKAIEQHYSFLTEPLSIKTYMHRFRLLLHLEEIECFVNFRNYDRDRAHFLRDGE-- 564
            .:|                :.|.|:|..:....||...|.:::  ::|  |...:...::.|:
  Rat  1230 TSS----------------IIEHLNILLFGLAQRLYKALSKVD--ISF--YTSSKGEMMKSGKNN 1274

  Fly   565 -------------------------FLTLQ------------IENLA-------ERRPSLV---- 581
                                     |.|..            :|::.       |.:|:::
  Rat  1275 SPSCHHNQPAKLVMVKKEGPNKGRLFYTCDKPKGNQCKFFKWLEDVTPEQLSQNESQPNMIFNDI 1339

  Fly   582 --IGDTLRVINPWSDPDSQTTKSYEGIIHKVLFDRILLKFHSSFQEKYNGEDYRL-----EFYFS 639
              ||..||         ||....||..       ::||:....||:|.:|:..:|     |||..
  Rat  1340 KSIGSYLR---------SQKIAVYEEC-------QLLLRKGFDFQKKQHGKLKKLATVNPEFYSE 1388

  Fly   640 RYS------FRKQHHA---------ISKIVG------VMGEDFLFPSKVTKRENPQLDVYMKDD- 682
            ..|      .||:..:         |||.:.      :....|..||.|.:.|...|..|...:
  Rat  1389 TKSKLYLKLSRKESSSVYSKGDLWVISKTLDFELDTFIACSAFFGPSSVNEVELLPLKGYFPSNW 1453

  Fly   683 ----------------DMYLYDSKLEWYNQS---------------------------------- 697
                            ::.:..:..:::|.:
  Rat  1454 PTNITVHALLVCNVSTELTMLQNIQDYFNPATLPLMPYLLAMSQSATVSSKNVSKRKFIPPAITS 1518

  Fly   698 -------------------------LNSIQKRAVFNIL-----RGEAENI--PY-------VLFG 723
                                     ||:.|..|:..|.     ||..|:.  |:       |:.|
  Rat  1519 IKTKFELLHLGATLQLARELINVHRLNNDQASALMQIAQMMASRGSDEDALEPFSHSLPITVIHG 1583

  Fly   724 PPGSGKTMTLIETLLQLV------------RNLPGARILVGTPSNSSADLVTKRLIDSKALLQGD 776
            ..|:||:..|...:|.||            |..|. ::|:.:.:|.:.|.|   |:...:|....
  Rat  1584 VFGAGKSYLLAVVILFLVELFEKCDSEAVGRARPW-KLLISSSTNVAVDRV---LLGLLSLGFEK 1644

  Fly   777 FIRLVSYNQVEKDLIPPEIMSYCATSDVGAVGSCEDKMMVTES-------GLKLRCQAKFIGTHR 834
            |||:.|..::.|.::|   .|..|:||..:....|...::.|.       .::...:...:||:|
  Rat  1645 FIRVGSVRKIAKPVLP---YSLHASSDNESEQLKELHALMREELTPIERVYVRKSIEQHKLGTNR 1706

  Fly   835 ITISTCTTLG-NFLQLGFPAGH---FTHVLFDEAGQCTEPETMVPIVMLTKKRSQVVLSGDPRQL 895
            :.:.....:| ......||..:   |..|:.||..|.|||.:::||...  :..:::|.|||:||
  Rat  1707 VLLKQARVVGITCAACPFPCMNDLKFPVVVLDECSQMTEPASLLPIARF--ECEKLILVGDPKQL 1769

  Fly   896 -QSIVTSRIASKMGFSISFLERLLERSPYRKDLQRFPESSGYNPLVLTKLLYNYRALPSIMSIYS 959
             .:|..|..|...|...:..:||.              ..|:.|:   :|...||..|.|.:|.:
  Rat  1770 PPTIQGSDAAHGNGLEQTLFDRLC--------------LMGHKPI---QLRTQYRCHPVISAIAN 1817

  Fly   960 RLFYDDELIPVLSEKDSRESRLLSKLRCVFESEKDIPQAHGTFFYGIIGENRQNNDSPSWFNPQE 1024
            .|||:..|:..:||::  .|.:|..|..:             .||.:.|..:...:: |:.|..|
  Rat  1818 DLFYEGNLVNGISERE--RSPVLEWLPTL-------------CFYNVTGTEQVEREN-SFVNVAE 1866

  Fly  1025 VREVFLMTIALYRANVTADQIGIITPYQKQVKMLRSMFIGTDVVMP-----KIGSVEEFQGQERD 1084
            ......:..:|..:.:....||:||.|:.|:..:.|:....||..|     ::.:|:.|||.|::
  Rat  1867 AAFTLKLIRSLIASGLEGSMIGVITLYKSQMYKICSLLSAVDVDHPDVKAVEVSTVDAFQGAEKE 1931

  Fly  1085 IILISTVRSSEEILRMDARFSLGFVRCSKRLNVAVSRARAMMIIFGNPHLLAVDECWRQLILFC 1148
            ||::|.||:.:          :||:...||:|||::|.|..::|.|:...|..::.|.::|..|
  Rat  1932 IIILSCVRTRQ----------VGFIDSEKRMNVALTRGRRHLLIIGSLSCLRKNQLWGRVIQHC 1985

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
armi	NP_001014556.1	AAA_11	698..902	CDD:289831	61/241 (25%)
		AAA_19	720..768	CDD:289986	16/59 (27%)
		DNA2	<840..1155	CDD:224037	84/319 (26%)
		UvrD_C_2	909..1132	CDD:304668	57/227 (25%)
Zgrf1	XP_006233356.1	DUF2439	3..75	CDD:402138
		zf-GRF	1276..1320	CDD:399670	3/43 (7%)
		DEAD-like_helicase_N	1543..1807	CDD:421690	69/289 (24%)
		AAA_12	1784..1968	CDD:404073	56/226 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900