DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment armi and Ighmbp2

DIOPT Version :9

Sequence 1:	NP_001014556.1	Gene:	armi / 38427	FlyBaseID:	FBgn0041164	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	NP_113774.2	Gene:	Ighmbp2 / 29532	RGDID:	68325	Length:	988	Species:	Rattus norvegicus

Alignment Length:	736	Identity:	178/736 - (24%)
Similarity:	297/736 - (40%)	Gaps:	179/736 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   479 TKRRFVALRLGCFEVPKELRQICLTSERRQEMIKAIEQHYSFLTEPLSIKTYMHRFRLLLHLEEI 543
            |...|||.:|...|:           ||..|    :|:..|: .|..|:|....|...||.|:.
  Rat     5 TVESFVAQQLQLLEL-----------ERDAE----VEERRSW-QEHSSLKELQSRGVCLLKLQV- 52

  Fly   544 ECFVNFRNYDRDRAHFLRDGEFLTLQIENLAERRP------------SLVIGDTLRVINPWSDPD 596
                              .|:...|..:.|....|            |...||.:.:.:     .
  Rat    53 ------------------SGQRTGLYGQRLVTFEPRKFGPAVVLPSNSFTSGDIVGLYD-----T 94

  Fly   597 SQTTKSYEGIIHKVLFDRILLKFHSS--FQEKYNGED-YRLEFYFSRYSFR---------KQHHA 649
            :::::...|::.::....:::.|..|  ||...:.|: |||....:..:::         |::|:
  Rat    95 NESSQLATGVLTRITQKSVIVAFDESHDFQLNLDRENTYRLLKLANDVTYKRLKKALLTLKKYHS 159

  Fly   650 --ISKIVGVM--GEDFLFPSKVTKRENPQLDVYMKDDDMYLYDSKLEWYNQSLNSIQKRAV-FNI 709
              .|.::.|:  |..   ||..|  |.|                .|.:||.:|:..||.|| |.:
  Rat   160 GPASSLIDVLLGGST---PSPAT--EIP----------------PLTFYNTTLDPSQKEAVSFAL 203

  Fly   710 LRGEAENIPYVLFGPPGSGKTMTLIETLLQLVRNLPGARILVGTPSNSSADLVTKRLIDSKALLQ 774
            .:.|..    ::.||||:|||.|::|.:||.|:.  |.::|...|||.:.|.:.:||    ||.:
  Rat   204 AQKEVA----IIHGPPGTGKTTTVVEIILQAVKQ--GLKVLCCAPSNIAVDNLVERL----ALCK 258

  Fly   775 GDFIRL---------VSYNQVEKDLIPPEIMSYCA---------------TSDVGAVGSCEDKMM 815
            ...:||         |..:.::..|...:.....|               |.|.....:..:::.
  Rat   259 KQILRLGHPARLLESVQQHSLDAVLARSDNAQIVADIRRDIDQVFGKNKKTQDKREKSNFRNEIK 323

  Fly   816 VTESGLKLRCQAKFI---GTHRITISTCT--TLGNFLQLGFPAGHFTHVLFDEAGQCTEPETMVP 875
            :....||.|.:|..:   ....:.::|.|  :....|:| .|..:|..|:.||..|..|....:|
  Rat   324 LLRKELKEREEAAIVQSLSAADVVLATNTGASTDGPLKL-LPEDYFDVVVVDECAQALEASCWIP 387

  Fly   876 IVMLTKKRSQVVLSGDPRQLQSIVTSRIASKMGFSISFLERLLERSPYRKDLQRFPESSGYNPLV 940
            ::    |..:.:|:||.:||.....|..|:..|.|.|.:|||.|:               :...|
  Rat   388 LL----KAPKCILAGDHKQLPPTTVSHKAALAGLSRSLMERLAEK---------------HGAAV 433

  Fly   941 LTKLLYNYRALPSIMSIYSRLFYDDELIPVLSEKDSRESRLLSKLRCVFESEK-DIP-QAHGTFF 1003
            :..|...||...:|....|...|..:    |:...|....||..|..|.::|: .:| ....|..
  Rat   434 VRMLAVQYRMHQAITRWASEAMYHGQ----LTAHPSVAGHLLKDLPGVADTEETSVPLLLIDTAG 494

  Fly  1004 YGIIGENRQNNDSPSWFNPQEVREVFLMTIALYRANVTADQIGIITPYQKQVKMLRSMFIGTDVV 1068
            .|::  ..:..||.|..||.|||.|.|...||..|.|.|..|.:|.||..||.:||.........
  Rat   495 CGLL--ELEEEDSQSKGNPGEVRLVTLHIQALVDAGVQAGDIAVIAPYNLQVDLLRQSLSNKHPE 557

  Fly  1069 MPKIGSVEEFQGQERDIILISTVRSSEEILRMDARFSLGFVRCSKRLNVAVSRARAMMIIFGNPH 1133
            : :|.||:.|||:|::.::::.|||:.       :..:||:...:|:||||:|||..:.:..:.|
  Rat   558 L-EIKSVDGFQGREKEAVILTFVRSNR-------KGEVGFLAEDRRINVAVTRARRHVAVICDSH 614

  Fly  1134 LLAVDECWRQLILFCVKNNAY 1154
                          .|.|:|:
  Rat   615 --------------TVNNHAF 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
armi	NP_001014556.1	AAA_11	698..902	CDD:289831	58/233 (25%)
		AAA_19	720..768	CDD:289986	20/47 (43%)
		DNA2	<840..1155	CDD:224037	90/319 (28%)
		UvrD_C_2	909..1132	CDD:304668	66/224 (29%)
Ighmbp2	NP_113774.2	TIGR00376	19..640	CDD:273041	172/722 (24%)
		SS DNA-binding. /evidence=ECO:0000250	637..783
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	651..722
		R3H_Smubp-2_like	724..782	CDD:100070
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	765..820
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	835..872
		Nuclear localization signal. /evidence=ECO:0000255	857..861
		ZnF_AN1	890..930	CDD:197545
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	943..988
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810