DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment armi and Setx

DIOPT Version :9

Sequence 1:	NP_001014556.1	Gene:	armi / 38427	FlyBaseID:	FBgn0041164	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	XP_006498142.1	Gene:	Setx / 269254	MGIID:	2443480	Length:	2701	Species:	Mus musculus

Alignment Length:	1380	Identity:	286/1380 - (20%)
Similarity:	481/1380 - (34%)	Gaps:	467/1380 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RNREDILESLDRENSFLDQKLMEEKMDQQLKANPNEINGVLSNKIAELTHGLSEMDVSKESSCTA 78
            :|.:.:|.|.|.:...|.:....:|.|...| |.:.:      :::.:..|...::...:.....
Mouse  1325 KNNKKLLTSQDLQFQRLMRSRSHKKRDFDYK-NTDTV------RVSRIVQGSDVLEADSDEPDDH 1382

  Fly    79 RKGVITSLDGDRGVIDKDVLFETKVAEDIILDLHVG--CVV---EYLTFTTGEAMRVVKVKSILE 138
            |.....::..:: .:.|.:|.:|:|||........|  |:|   |....:.|....||.|.:
Mouse  1383 RVSEPLAISNEK-QLAKCMLSKTEVAEASSDPWVTGITCLVNQCESRVLSGGVPTDVVMVSA--- 1443

  Fly   139 HSWEDTSQKEIEKAVDNLKNEKPTFFNTETRSVLGLISQRLASSIDVETEYGQLTVELDNIEMNF 203
                      .|..||.      .....:...|..:.:...|||.|.:.:......:.|..:|:.
Mouse  1444 ----------SEDPVDG------GAVTVQVGEVASVKAAEPASSSDTDDDDNLFLTQHDPQDMDL 1492

  Fly   204 IPTNGDRVRLECN----IQLDDGFVDKQGEILEVTK-----LFPTRIQEGEKC------------ 247
            .....::..:..:    :|.:|.....|.|.|.:||     ...|...:||.|
Mouse  1493 CSQLENKTIIVAHKKDTVQREDSLSRPQLESLSITKCKYKDCVETTKNQGEYCPRHSEAKAADDG 1557

  Fly   248 IVERVYVHMVVLGPETYILKTDLPTGTDLHLGDIV--LADLIE-CQYSKFTRRAIKITPLEKNFG 309
            :..:..:.:.|..|    |:   ||.|.:......  .|:|.: .:.:...:.|:|    .|:.|
Mouse  1558 LFRKPGLPLSVARP----LR---PTTTKIFSSSSASRTANLSKSLESTTLQQSALK----NKSSG 1611

  Fly   310 A---TKLTQQSSMGSSGS-GKAVTVTGVNRFITAELWQKESVSLKLTNNLNRTLRLESITVCNDS 370
            |   .|:|..|||||... .:..::..:..|.|.....|:  |.|||.:.||.         ..:
Mouse  1612 AQPNLKVTPPSSMGSQKPVAEVKSLCNIFHFQTPSSSSKQ--SCKLTFSENRP---------TSA 1665

  Fly   371 ESQLSVVSPLESKEISSGSEITVTFEIHTQFLGEAIE-KY--VLNFDL--------------LKV 418
            .|.::::.|.:|              |...|:.|.:: ||  .||||.              :.|
Mouse  1666 ASPVNILLPSQS--------------IFDTFIKEVLKWKYQMFLNFDKCGAPTSLCQSISRPVPV 1716

  Fly   419 R--------RVF-TVIVCKTKEEVAEAEKRMIAAEALMAPGRNSQERSRFYANQVWCNKVDVIPG 474
            |        .|| .:|:....|.||:        |.|.:|.:.:     ||..|:
Mouse  1717 RFQDCAEYFNVFLPLIILNAFETVAQ--------EWLSSPNKEN-----FYQLQL---------- 1758

  Fly   475 QQIVTKRRFVA---------LRLGCFEV-----PKELRQICLTSER----RQEMIKAIEQHYSFL 521
                  |:|.|         :.|...|:     |||...:.|..|:    |..|...  .||
Mouse  1759 ------RKFPADYKKYWEFLIYLNESELAKQLHPKENDLVFLAPEKSYMDRHGMQDC--SHY--- 1812

  Fly   522 TEPLSIKTYMHRFR--LLLHLEEIECFVNFRNYDRDRAHFLRDGEFLTLQIENLAERRPSLVIGD 584
                 ...|:|:||  .::...:.||.:..:..|.           |...::||..   .:||..
Mouse  1813 -----YCGYVHKFRRTSVMRSGKAECSLCIQTQDT-----------LPASVKNLTR---CIVISS 1858

  Fly   585 TLRVINPWSDPDSQTTKSYEGIIHKVLFDRILLKFHSSFQEKYNGEDYRLEFYFSRYSFRKQHHA 649
            .:            ||                       |.|...        .|..|.|.|
Mouse  1859 LV------------TT-----------------------QRKLKA--------MSLLSSRNQ--- 1877

  Fly   650 ISKIVGVMGEDFLFPSKVTKRENPQLDVYMKDDDMYLYDSKLEWYNQSLNSIQKRAVFNILRGEA 714
                   :....|.|       || :|...| |.:.....::..|.:..|..||:|: .......
Mouse  1878 -------LARAVLNP-------NP-MDFCTK-DLLTTTSERIVAYLKDFNEDQKKAI-ETAYAMV 1925

  Fly   715 ENIPYV-----LFGPPGSGKTMTLIETLLQLV--------------RNLPGARILVGTPSNSSAD 760
            ::.|.|     :.||||:||:.|::..|.:|:              ..:...|:||..|||::.|
Mouse  1926 KHSPSVAKICLIHGPPGTGKSKTIVGLLYRLLTENQRKGHSDENFNAKIKQNRVLVCAPSNAAVD 1990

  Fly   761 LVTKRLI--------DSKALLQ--GDFIRLV------SYN--------------QVEKDLIPPEI 795
            .:.|::|        |.|..|.  || |.||      |.|              :::||| |..|
Mouse  1991 ELMKKIILEFKEKCKDKKNPLGNCGD-INLVRLGPEKSINTEVLKFSLDSQVNHRMKKDL-PSHI 2053

  Fly   796 MSYCATSDV-----------------G------------AVGSCEDKMMVTE----SGLKLRCQA 827
            .......::                 |            |:.|.|.:.:.::    .|...|.|.
Mouse  2054 QEMLRRKEILDAQLDELSRQRALCRGGREMQRQELDEHIAIVSKERQELASKIKEVQGRPQRAQN 2118

  Fly   828 KFIGTHRITISTCTTLGNFL-------QLGFPAGHFTHVLFDEAGQCTEPETMVPIVMLTKKRSQ 885
            ..|....:...|.:|.|..|       |.|.|   |:.|:.|||||..|.||:.|::   .:.::
Mouse  2119 TIILESHVICCTLSTSGGLLLESAFRGQGGVP---FSCVIVDEAGQSCEVETLSPLI---HRCNK 2177

  Fly   886 VVLSGDPRQLQSIVTSRIASKMGFSISFLER---LLERSPYRKDLQRFPESSGYNPLVLTKLLYN 947
            ::|.|||:||...|.|..|.:.|:..|.:.|   |||.:..:..:.|.|         :.:|...
Mouse  2178 LILVGDPKQLPPTVISMKAQEYGYDQSMMARFCKLLEENVEQNMIGRLP---------VLQLTIQ 2233

  Fly   948 YRALPSIMSIYSRLFYDDELIPVLSEKDSRESRLLSKLRC----------VFESEKDIPQAHGTF 1002
            ||..|.|....|...|:         |:.:.:||...:||          ||:
Mouse  2234 YRMHPDICLFPSNYVYN---------KNLKTNRLTESIRCSSEWPFQPYLVFD------------ 2277

  Fly  1003 FYGIIGENRQNNDSPSWFNPQEVREV--FLMTIALYRANVTADQIGIITPYQKQVKMLR------ 1059
                :|:..:..|:.|:.|.||::.|  .:..|...|.:::...|||||.|:.|..|::
Mouse  2278 ----VGDGSERRDNDSYINVQEIKLVMEIIKLIKEKRKDISFRNIGIITHYKAQKTMIQKDLEKE 2338

  Fly  1060 -----------------------------SMF------IGTDVVM----------------PKIG 1073
                                         |.|      :|:..|.                .::.
Mouse  2339 FDKKGLLQPIMMGESRQQDSEASKQQQKSSEFMHASDELGSSTVTQSGISSLENGATHTGPAEVD 2403

  Fly  1074 SVEEFQGQERDIILISTVRSSEEILRMDARFSLGFVRCSKRLNVAVSRARAMMIIFGNPHLLAVD 1138
            :|:.|||:::|.|:::.||:|.      .:.|:||:...:||||.::||:..:.|.|:...|..:
Mouse  2404 TVDAFQGRQKDCIIVTCVRASA------VQGSIGFLASLQRLNVTITRAKYSLFILGHLRTLMEN 2462

  Fly  1139 ECWRQLILFCVKNNA 1153
            :.|.:||....|..|
Mouse  2463 QHWYELIQDAQKRGA 2477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
armi	NP_001014556.1	AAA_11	698..902	CDD:289831	72/292 (25%)
		AAA_19	720..768	CDD:289986	19/74 (26%)
		DNA2	<840..1155	CDD:224037	95/393 (24%)
		UvrD_C_2	909..1132	CDD:304668	62/294 (21%)
Setx	XP_006498142.1	SEN1_N	37..>334	CDD:372274
		DEXXQc_SETX	1910..2235	CDD:350800	83/342 (24%)
		AAA_12	2201..2455	CDD:372468	61/293 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810