DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment armi and SETX

DIOPT Version :9

Sequence 1:	NP_001014556.1	Gene:	armi / 38427	FlyBaseID:	FBgn0041164	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	NP_001338457.1	Gene:	SETX / 23064	HGNCID:	445	Length:	2706	Species:	Homo sapiens

Alignment Length:	1336	Identity:	287/1336 - (21%)
Similarity:	472/1336 - (35%)	Gaps:	428/1336 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RNREDILESLDRENSFLDQKLMEEKMDQQLKANPNEINGVLSNKIAELTHGLSEMDVSKESSCTA 78
            ||.:.:|.|            .|.:|.:|::....:....||:  .|.|      ||.:..|.||
Human  1337 RNNKKLLTS------------QELQMQRQIRPKSQKNRRRLSD--CEST------DVKRAGSHTA 1381

  Fly    79 RKGVITSLDGDRGVIDKDVLFETKVAEDIILDLHVGCV--------VEYLTFTTGEAMRVVKVKS 135
            :...|...:.||.  |.:....|:|..:......:.|:        .::.:..|.:|..:.:..|
Human  1382 QNSDIFVPESDRS--DYNCTGGTEVLANSNRKQLIKCMPSEPETIKAKHGSPATDDACPLNQCDS 1444

  Fly   136 ILEHSWEDTSQKEIEKAVDNLKNEKPTFFNTETRSVLGLISQRLASSIDVETEYGQLT------- 193
            ::.:....|::..:..:.|.|....||..:.|   :..|......||.|.|.:...||
Human  1445 VVLNGTVPTNEVIVSTSEDPLGGGDPTARHIE---MAALKEGEPDSSSDAEEDNLFLTQNDPEDM 1506

  Fly   194 -----VELDNIEMNFIPTNGDRVRLE----CNIQLD--DGFVDKQGEILEVTKLFPTRIQEGEKC 247
                 :|.||.::..:....|.|.:|    ...||:  .|...|..:.||.||      .:||.|
Human  1507 DLCSQMENDNYKLIELIHGKDTVEVEEDSVSRPQLESLSGTKCKYKDCLETTK------NQGEYC 1565

  Fly   248 IVERVYVHMVVLGPETYILKTDLPTGTDLHLGDIVLADLIECQYSKFTRRAIKITPLEKNFGATK 312
            ...    ..|....|....|..||...                 ||      .:.|..|.|.:..
Human  1566 PKH----SEVKAADEDVFRKPGLPPPA-----------------SK------PLRPTTKIFSSKS 1603

  Fly   313 LTQQSSMGSS---GSGKAVTVTGVNRFITAELWQKESVSL-------KLTNNLNRTLRLESITVC 367
            .::.:.:..|   .|..:.::...::.|.:.|...:.|.|       ::.|:.| .|..:|   .
Human  1604 TSRIAGLSKSLETSSALSPSLKNKSKGIQSILKVPQPVPLIAQKPVGEMKNSCN-VLHPQS---P 1664

  Fly   368 NDSESQLSVVSPLESKEISSGSEITVTF---EIHTQFLGEAIE-KY--VLNF------------- 413
            |:|..|...|...|||...|.|.:.:..   .:...|:.|.:: ||  .|||
Human  1665 NNSNRQGCKVPFGESKYFPSSSPVNILLSSQSVSDTFVKEVLKWKYEMFLNFGQCGPPASLCQSI 1729

  Fly   414 ------------DLLKVRRVFTVIVCKTKEEVAEAEKRMIAAEALMAPGRNSQERSRFYANQVWC 466
                        |...|  .|.::|..|.|.||:        |.|     ||..|..||..||
Human  1730 SRPVPVRFHNYGDYFNV--FFPLMVLNTFETVAQ--------EWL-----NSPNRENFYQLQV-- 1777

  Fly   467 NKVDVIPGQQIVTKRRFVALRLGCFE--------------VPKELRQICLTSERRQEM------- 510
                          |:|.|..:..:|              .|||...:.|..||..|.
Human  1778 --------------RKFPADYIKYWEFAVYLEECELAKQLYPKENDLVFLAPERINEEKKDTERN 1828

  Fly   511 -IKAIEQHYSFLTEPLSIKTYMHRFRLLLHLEEIECFVNFRNYDRDRAHFLRDGE---FLTLQIE 571
             |:.:.:::|         .|:|:||                    |...:|:|:   :|::|.:
Human  1829 DIQDLHEYHS---------GYVHKFR--------------------RTSVMRNGKTECYLSIQTQ 1864

  Fly   572 -----NLAERRPSLVIGDTLRVINPWSDPDSQTTKSYEGIIHKVLFDRILLKFHSSFQEKYNGED 631
                 ||.|....:||...:            ||:
Human  1865 ENFPANLNELVNCIVISSLV------------TTQ------------------------------ 1887

  Fly   632 YRLEFYFSRYSFRKQHHAISKIVGVMGEDFLFPSKVTKRENPQLDVYMKDDDMYLYDSKLEWYNQ 696
                        ||     .|.:.::|........|.   ||....:...|.:.....::..|.:
Human  1888 ------------RK-----LKAMSLLGSRNQLARAVL---NPNPMDFCTKDLLTTTSERIIAYLR 1932

  Fly   697 SLNSIQKRAVFNILRGEAENIPYV-----LFGPPGSGKTMTLIETLLQLV--------------R 742
            ..|..||:|: .......::.|.|     :.||||:||:.|::..|.:|:              .
Human  1933 DFNEDQKKAI-ETAYAMVKHSPSVAKICLIHGPPGTGKSKTIVGLLYRLLTENQRKGHSDENSNA 1996

  Fly   743 NLPGARILVGTPSNSSADLVTKRLI--------DSKALLQ--GDFIRLVSYNQVEKDLIPPEIMS 797
            .:...|:||..|||::.|.:.|::|        |.|..|.  || |.||.... ||. |..|::.
Human  1997 KIKQNRVLVCAPSNAAVDELMKKIILEFKEKCKDKKNPLGNCGD-INLVRLGP-EKS-INSEVLK 2058

  Fly   798 YCATSDVG--------------------------------------------------AVGSCED 812
            :...|.|.                                                  :..|.|.
Human  2059 FSLDSQVNHRMKKELPSHVQAMHKRKEFLDYQLDELSRQRALCRGGREIQRQELDENISKVSKER 2123

  Fly   813 KMMVTE----SGLKLRCQAKFIGTHRITISTCTTLGNFL-------QLGFPAGHFTHVLFDEAGQ 866
            :.:.::    .|...:.|:..|....|...|.:|.|..|       |.|.|   |:.|:.|||||
Human  2124 QELASKIKEVQGRPQKTQSIIILESHIICCTLSTSGGLLLESAFRGQGGVP---FSCVIVDEAGQ 2185

  Fly   867 CTEPETMVPIVMLTKKRSQVVLSGDPRQLQSIVTSRIASKMGFSISFLE---RLLERSPYRKDLQ 928
            ..|.||:.|::   .:.::::|.|||:||...|.|..|.:.|:..|.:.   ||||.:.....:.
Human  2186 SCEIETLTPLI---HRCNKLILVGDPKQLPPTVISMKAQEYGYDQSMMARFCRLLEENVEHNMIS 2247

  Fly   929 RFPESSGYNPLVLTKLLYNYRALPSIMSIYSRLFYDDELIPVLSEKDSRESRLLSKLRCVFESEK 993
            |.|         :.:|...||..|.|....|...|:..|         :.:|....:||    ..
Human  2248 RLP---------ILQLTVQYRMHPDICLFPSNYVYNRNL---------KTNRQTEAIRC----SS 2290

  Fly   994 DIP-QAHGTFFYGIIGENRQNNDSPSWFNPQEVREV--FLMTIALYRANVTADQIGIITPYQKQV 1055
            |.| |.:..|   .:|:..:..|:.|:.|.||::.|  .:..|...|.:|:...|||||.|:.|.
Human  2291 DWPFQPYLVF---DVGDGSERRDNDSYINVQEIKLVMEIIKLIKDKRKDVSFRNIGIITHYKAQK 2352

  Fly  1056 KML-RSMFIGTDVVMP-KIGSVEEFQGQERDIILISTVRSSEEILRMDARFSLGFVRCSKRLNVA 1118
            .|: :.:....|...| ::.:|:.|||:::|.::::.||::      ..:.|:||:...:||||.
Human  2353 TMIQKDLDKEFDRKGPAEVDTVDAFQGRQKDCVIVTCVRAN------SIQGSIGFLASLQRLNVT 2411

  Fly  1119 VSRARAMMIIFGNPHLLAVDECWRQLI--LFCVKNN 1152
            ::||:..:.|.|  ||..:    .||:  .|||..|
Human  2412 ITRAKYSLFILG--HLRTL----MQLLPRSFCVHVN 2441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
armi	NP_001014556.1	AAA_11	698..902	CDD:289831	69/293 (24%)
		AAA_19	720..768	CDD:289986	19/74 (26%)
		DNA2	<840..1155	CDD:224037	95/330 (29%)
		UvrD_C_2	909..1132	CDD:304668	60/230 (26%)
SETX	NP_001338457.1	SEN1_N	37..>351	CDD:315409
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1158..1219
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1237..1258
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1351..1385		10/41 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1579..1604		8/47 (17%)
		AAA_11	1933..2218	CDD:315699	69/294 (23%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	2070..2087		0/16 (0%)
		AAA_12	2225..2424	CDD:315700	60/231 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2503..2525
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2585..2606
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2626..2706
		Necessary for nuclear localization	2690..2706
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148890at33208
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820