DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment armi and Ighmbp2

DIOPT Version :9

Sequence 1:	NP_001014556.1	Gene:	armi / 38427	FlyBaseID:	FBgn0041164	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	NP_033238.2	Gene:	Ighmbp2 / 20589	MGIID:	99954	Length:	993	Species:	Mus musculus

Alignment Length:	727	Identity:	179/727 - (24%)
Similarity:	296/727 - (40%)	Gaps:	161/727 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   479 TKRRFVALRLGCFEVPKELRQICLTSERRQEMIKAIEQHYSFLTEPLS-----IKTYMHRFRLLL 538
            |...|||.:|...|:.::..    ..|||.      .|.:|.|.|..|     :|..:...|..|
Mouse     5 TVESFVAQQLQLLELERDAE----VEERRS------WQEHSSLRELQSRGVCLLKLQVSSQRTGL 59

  Fly   539 HLEEIECFVNFRNYDRDRAHFLRDGEFLTLQIENLAERRPSLVIGDTLRVINPWSDPDSQTTKSY 603
            :.:.:   |.|.......|..|....|.:..|..|.         ||           ::.::..
Mouse    60 YGQRL---VTFEPRKFGPAVVLPSNSFTSGDIVGLY---------DT-----------NENSQLA 101

  Fly   604 EGIIHKVLFDRILLKFHSSFQEKYN---GEDYRLEFYFSRYSFR---------KQHHA--ISKIV 654
            .|::.::....:.:.|..|...:.|   ...|||....:..:::         |::|:  .|.::
Mouse   102 TGVLTRITQKSVTVAFDESHDLQLNLDRENTYRLLKLANDVTYKRLKKALMTLKKYHSGPASSLI 166

  Fly   655 GVMGEDFLFPSKVTKRENPQLDVYMKDDDMYLYDSKLEWYNQSLNSIQKRAV-FNILRGEAENIP 718
                 |.|..|..   .:|.:::           ..|.:||.:|:..||.|| |.:.:.|..
Mouse   167 -----DILLGSST---PSPAMEI-----------PPLSFYNTTLDLSQKEAVSFALAQKELA--- 209

  Fly   719 YVLFGPPGSGKTMTLIETLLQLVRNLPGARILVGTPSNSSADLVTKRLIDSKALLQGDFIRL--- 780
             ::.||||:|||.|::|.:||.|:.  |.::|...|||.:.|.:.:||    ||.:...:||
Mouse   210 -IIHGPPGTGKTTTVVEIILQAVKQ--GLKVLCCAPSNIAVDNLVERL----ALCKKRILRLGHP 267

  Fly   781 ------VSYNQVEKDLIPPEIMSYCA---------------TSDVGAVGSCEDKMMVTESGLKLR 824
                  |.::.::..|...:.....|               |.|....|:...::.:....||.|
Mouse   268 ARLLESVQHHSLDAVLARSDNAQIVADIRRDIDQVFGKNKKTQDKREKGNFRSEIKLLRKELKER 332

  Fly   825 CQAKFIGT---HRITISTCTTLGNF--LQLGFPAGHFTHVLFDEAGQCTEPETMVPIVMLTKKRS 884
            .:|..:.:   ..:.::|.|...:.  |:| .|..:|..|:.||..|..|....:|::    |..
Mouse   333 EEAAIVQSLTAADVVLATNTGASSDGPLKL-LPEDYFDVVVVDECAQALEASCWIPLL----KAP 392

  Fly   885 QVVLSGDPRQLQSIVTSRIASKMGFSISFLERLLERSPYRKDLQRFPESSGYNPLVLTKLLYNYR 949
            :.:|:||.|||.....|..|:..|.|.|.:|||.|:           ..:|    |:..|...||
Mouse   393 KCILAGDHRQLPPTTVSHRAALAGLSRSLMERLAEK-----------HGAG----VVRMLTVQYR 442

  Fly   950 ALPSIMSIYSRLFYDDELIPVLSEKDSRESRLLSKLRCVFESEKD-IP-QAHGTFFYGIIGENRQ 1012
            ...:||...|...|..:    |:...|....||..|..|.::|:. :| ....|...|::  ..:
Mouse   443 MHQAIMCWASEAMYHGQ----LTSHPSVAGHLLKDLPGVTDTEETRVPLLLIDTAGCGLL--ELE 501

  Fly  1013 NNDSPSWFNPQEVREVFLMTIALYRANVTADQIGIITPYQKQVKMLRSMFIGTDVVMPKIGSVEE 1077
            ..||.|..||.|||.|.|...||..|.|.|..|.:|.||..||.:||.........: :|.||:.
Mouse   502 EEDSQSKGNPGEVRLVTLHIQALVDAGVQAGDIAVIAPYNLQVDLLRQSLSNKHPEL-EIKSVDG 565

  Fly  1078 FQGQERDIILISTVRSSEEILRMDARFSLGFVRCSKRLNVAVSRARAMMIIFGNPHLLAVDECWR 1142
            |||:|::.:|::.|||:.       :..:||:...:|:||||:|||..:.:..:.|
Mouse   566 FQGREKEAVLLTFVRSNR-------KGEVGFLAEDRRINVAVTRARRHVAVICDSH--------- 614

  Fly  1143 QLILFCVKNNAY 1154
                 .|.|:|:
Mouse   615 -----TVNNHAF 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
armi	NP_001014556.1	AAA_11	698..902	CDD:289831	60/233 (26%)
		AAA_19	720..768	CDD:289986	20/47 (43%)
		DNA2	<840..1155	CDD:224037	94/319 (29%)
		UvrD_C_2	909..1132	CDD:304668	69/224 (31%)
Ighmbp2	NP_033238.2	TIGR00376	19..640	CDD:273041	173/713 (24%)
		AAA_19	197..255	CDD:289986	24/67 (36%)
		AAA_12	417..613	CDD:289832	69/224 (31%)
		SS DNA-binding. /evidence=ECO:0000250	637..783
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	650..723
		R3H_Smubp-2_like	724..782	CDD:100070
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	765..815
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	837..872
		Nuclear localization signal. /evidence=ECO:0000255	862..866
		ZnF_AN1	895..935	CDD:197545
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	953..993
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810