DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment armi and Upf1

DIOPT Version :9

Sequence 1:	NP_001014556.1	Gene:	armi / 38427	FlyBaseID:	FBgn0041164	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	NP_001116301.1	Gene:	Upf1 / 19704	MGIID:	107995	Length:	1124	Species:	Mus musculus

Alignment Length:	602	Identity:	161/602 - (26%)
Similarity:	256/602 - (42%)	Gaps:	129/602 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   603 YEGIIHKVLF-----DRILLKFHSS----FQEKYNGEDYRLEFYFSRYSFRKQHHAIS------- 651
            ::||.|.:..     |.|.::..||    .:..:|   ::::|.:...||.:...|:.
Mouse   380 WKGIGHVIKVPDNYGDEIAIELRSSVGAPVEVTHN---FQVDFVWKSTSFDRMQSALKTFAVDET 441

  Fly   652 --------KIVGVMGEDFLFPSKVTKRENPQLDVYMKDDDMYLYDSKLEWYNQSLNSIQKRAVFN 708
                    |::|...||.:...::.||...|          .|.|         ||..|..||..
Mouse   442 SVSGYIYHKLLGHEVEDVVIKCQLPKRFTAQ----------GLPD---------LNHSQVYAVKT 487

  Fly   709 ILRGEAENIPYVLFGPPGSGKTMTLIETLLQLVRNLPGARILVGTPSNSSADLVTKRL------- 766
            :|:....    ::.||||:|||:|....:..|.|...|. :||..|||.:.|.:|:::
Mouse   488 VLQRPLS----LIQGPPGTGKTVTSATIVYHLARQGNGP-VLVCAPSNIAVDQLTEKIHQTGLKV 547

  Fly   767 ----IDSKALLQGDFIRLVSYNQVEKDLIPPEIMSYCATSD-VGAVGSCEDKMMVTESGLKLRCQ 826
                ..|:..:......|..:||:......||:.......| .|.:.|.::|..   ..||...:
Mouse   548 VRLCAKSREAIDSPVSFLALHNQIRNMDSMPELQKLQQLKDETGELSSADEKRY---RALKRTAE 609

  Fly   827 AKFIGTHRITISTCTTLGNFLQLGFP---AGHFTHVLFDEAGQCTEPETMVPIVMLTKKRSQVVL 888
            .:.:....:...||...|:      |   ...|..:|.||:.|.||||.|||:|:..|   |::|
Mouse   610 RELLMNADVICCTCVGAGD------PRLAKMQFRSILIDESTQATEPECMVPVVLGAK---QLIL 665

  Fly   889 SGDPRQLQSIVTSRIASKMGFSISFLERLLERSPYRKDLQRFPESSGYNPLVLTKLLYNYRALPS 953
            .||..||..:|..:.|:|.|.|.|..|||:              ..|..|:   :|...||..|:
Mouse   666 VGDHCQLGPVVMCKKAAKAGLSQSLFERLV--------------VLGIRPI---RLQVQYRMHPA 713

  Fly   954 IMSIYSRLFYDDELIPVLSEKDSRESRLLSKLRCVFE---SEKDIPQAHGTFFYGIIGENRQNND 1015
            :.:..|.:||:..|...::..|        :::..|:   .:.|.|.    |||...|:....:.
Mouse   714 LSAFPSNIFYEGSLQNGVTAAD--------RVKKGFDFQWPQPDKPM----FFYVTQGQEEIASS 766

  Fly  1016 SPSWFNPQEVREVFLMTIALYRANVTADQIGIITPYQKQVKML--RSMFIGT-------DVVMPK 1071
            ..|:.|..|...|..:|..|.:|....|||||||||:.|...|  ...|.|:       :|   :
Mouse   767 GTSYLNRTEAANVEKITTKLLKAGAKPDQIGIITPYEGQRSYLVQYMQFSGSLHTKLYQEV---E 828

  Fly  1072 IGSVEEFQGQERDIILISTVRSSEEILRMDARFSLGFVRCSKRLNVAVSRARAMMIIFGNPHLLA 1136
            |.||:.|||:|:|.|::|.||::|       ...:||:...:|||||::|||..:||.|||..|:
Mouse   829 IASVDAFQGREKDFIILSCVRANE-------HQGIGFLNDPRRLNVALTRARYGVIIVGNPKALS 886

  Fly  1137 VDECWRQLILFCVKNNA 1153
            ....|..|:.:..:..|
Mouse   887 KQPLWNHLLSYYKEQKA 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
armi	NP_001014556.1	AAA_11	698..902	CDD:289831	61/218 (28%)
		AAA_19	720..768	CDD:289986	18/58 (31%)
		DNA2	<840..1155	CDD:224037	103/329 (31%)
		UvrD_C_2	909..1132	CDD:304668	70/234 (30%)
Upf1	NP_001116301.1	Sufficient for interaction with RENT2. /evidence=ECO:0000250	1..410		7/29 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..69
		DNA2	140..915	CDD:224037	161/602 (27%)
		DEXXQc_UPF1	476..709	CDD:350797	73/275 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1004..1053
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1066..1091
		[ST]-Q motif 1	1084..1085
		[ST]-Q motif 2	1102..1103
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1105..1124
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810