Protein Alignment armi and DNA2

DIOPT Version :10

• Sequence 1: NP_647816.2
• Gene: armi / 38427
• FlyBaseID: FBgn0041164
• Length: 1188
• Species: Drosophila melanogaster
• Sequence 2: XP_006717743.1
• Gene: DNA2 / 1763
• HGNCID: 2939
• Length: 1090
• Species: Homo sapiens
• Alignment Length: 1190
• Identity: 244/1190 - (20%)
• Similarity: 441/1190 - (37%)
• Gaps: 361/1190 - (30%)

  Fly    54 LSNKIAELTHGLSEMDVSKESSCT--ARKGVITSLDG----DRGVIDKD---------------- 96
            |.||         |:.:.:...|:  ...|.|..|:|    |..:||||
Human   104 LENK---------ELCILRNDWCSVPVEPGDIIHLEGDCTSDTWIIDKDFGYLILYPDMLISGTS 159

  Fly    97 -----------VLFET-KVAEDIILDLHVGCV-----------------VEYLTFTTGEAMRVVK 132
                       ||.|| :.::.....:.:|.|                 ::.|.|.|.:.:|.:|
Human   160 IASSIRCMRRAVLSETFRSSDPATRQMLIGTVLHEVFQKAINNSFAPEKLQELAFQTIQEIRHLK 224

  Fly   133 VKSILEHSWEDTSQKEIEKAVDNLKNEKPTFFNTETRSVLGLISQRLASSIDVETEYGQLTVELD 197
            ....|..| :|..::|:|..:.:.......|.:..|                 .|::.|:.:.|
Human   225 EMYRLNLS-QDEIKQEVEDYLPSFCKWAGDFMHKNT-----------------STDFPQMQLSL- 270

  Fly   198 NIEMNFIPTNGDRVRLECNIQLDDGFVDKQGEILEVTKLFPTRIQEGEKCIVERVYVHMVVLGPE 262
                   |::..:....|||              ||.|  |..|:|.             :..|.
Human   271 -------PSDNSKDNSTCNI--------------EVVK--PMDIEES-------------IWSPR 299

  Fly   263 TYIL-KTDLPTGTDLHLGDIVLADLIECQYSKFTRRAIKITPLEKNFGATKLTQQSSMGSSGSGK 326
            ..:. |.|:..|..:|.|       .:.:|        ||.|||...|
Human   300 FGLKGKIDVTVGVKIHRG-------YKTKY--------KIMPLELKTG----------------- 332

  Fly   327 AVTVTGVNRFITAELWQKESVSLKLTNNLNRTLRLESITVCNDSESQLSVVSPLESKEISSGSEI 391
                             |||.|:                   :..||: |:..|.|:|..:..|.
Human   333 -----------------KESNSI-------------------EHRSQV-VLYTLLSQERRADPEA 360

  Fly   392 TVTFEIHTQFLGEAIEKYVLNFDLLKVRRVFTVIVCKTKEEVAEAEKRMIAAEALMAPGRNSQER 456
            .:...:.|..:......::...:|||:|......:.....:.|..:|..:|:    .|....:|:
Human   361 GLLLYLKTGQMYPVPANHLDKRELLKLRNQMAFSLFHRISKSATRQKTQLAS----LPQIIEEEK 421

  Fly   457 SRFYANQVWCNKVDVIPGQQIVTKRRFVALRLGCFEVPKELRQICLTSERRQEMIKAIEQHYSFL 521
            :..|.:|:          .......|.|..::.|..||  :..:....|..|.:.:...:::|..
Human   422 TCKYCSQI----------GNCALYSRAVEQQMDCSSVP--IVMLPKIEEETQHLKQTHLEYFSLW 474

  Fly   522 TEPLSIKTYM------HRFRLLLHLEEIE----CFVNFRNYDRDRAHFLRDGEFL-TLQIENLAE 575
            ...|::::..      |:...|:...|:|    |..|.  ...:....:.||::| ..|.::.|.
Human   475 CLMLTLESQSKDNKKNHQNIWLMPASEMEKSGSCIGNL--IRMEHVKIVCDGQYLHNFQCKHGAI 537

  Fly   576 RRPSLVIGDTLRVINPWSDPDSQTTKSYEGIIHKV-------LFDRILLKFHSSF-----QEKYN 628
            ...:|:.||.:.|    |..:........|.:.::       |.||.|.....|.     ||:.|
Human   538 PVTNLMAGDRVIV----SGEERSLFALSRGYVKEINMTTVTCLLDRNLSVLPESTLFRLDQEEKN 598

  Fly   629 GEDYRLEFYFSRYSFRKQHHAISKIVGVMGEDFLFPSKVTKRENPQLDVYMKDDDMYLYDSK--L 691
            .:   ::......|...::..:||.:..:..||        || ||...|:  ..:..:|:|  :
Human   599 CD---IDTPLGNLSKLMENTFVSKKLRDLIIDF--------RE-PQFISYL--SSVLPHDAKDTV 649

  Fly   692 EWYNQSLNSIQKRAVFNILRGEAENIPYVLF-GPPGSGKTMTLIETLLQLVRNLPGARILVGTPS 755
            ....:.||..|::|:..:|..:    .|.|. |.||:|||.|:. ||::::... |..:|:.:.:
Human   650 ACILKGLNKPQRQAMKKVLLSK----DYTLIVGMPGTGKTTTIC-TLVRILYAC-GFSVLLTSYT 708

  Fly   756 NSSADLVTKRLIDSKALLQGDFIRLVSYNQVEKDLIPPEIMSYCATSDVGAVGSCEDKMMVTESG 820
            :|:.|.:..:|...|.    .|:||   .|::|  :.|.|..:           .|.::..::|.
Human   709 HSAVDNILLKLAKFKI----GFLRL---GQIQK--VHPAIQQF-----------TEQEICRSKSI 753

  Fly   821 LKLRCQAKFIGTHRITISTCTTLGNFLQLGFPAGHFTHVLFDEAGQCTEPETMVPIVMLTKKRSQ 885
            ..|....:...:..|..:||..:.:.:   |....|...:.|||.|.::|..:.|:..    ..:
Human   754 KSLALLEELYNSQLIVATTCMGINHPI---FSRKIFDFCIVDEASQISQPICLGPLFF----SRR 811

  Fly   886 VVLSGDPRQLQSIVTSRIASKMGFSISFLERLLERSPYRKDLQRFPESSGYNPLVLTKLLYNYRA 950
            .||.||.:||..:|.:|.|..:|.|.|..:||.:                 |...:.:|...||.
Human   812 FVLVGDHQQLPPLVLNREARALGMSESLFKRLEQ-----------------NKSAVVQLTVQYRM 859

  Fly   951 LPSIMSIYSRLFYDDEL-----------IPVLSEKDSRESRLLSKLRCVFESE-KDIPQAHGTFF 1003
            ...|||:.::|.|:.:|           |.:...||       .||...|.:: .|.|...|.|
Human   860 NSKIMSLSNKLTYEGKLECGSDKVANAVINLRHFKD-------VKLELEFYADYSDNPWLMGVF- 916

  Fly  1004 YGIIGENRQNNDSPSWFN------PQEVRE------------VFLMTIALYRANVTADQIGIITP 1050
                    :.|:...:.|      |::|.:            |||.:| ..:|..:...||||.|
Human   917 --------EPNNPVCFLNTDKVPAPEQVEKGGVSNVTEAKLIVFLTSI-FVKAGCSPSDIGIIAP 972

  Fly  1051 YQKQVKMLRSMFIGTDVVMPKIGSVEEFQGQERDIILISTVRSSE-----EILRMDARFSLGFVR 1110
            |::|:|::..: :...:.|.::.:|:::||:::.|:|:|.|||::     |:|: |.|
Human   973 YRQQLKIINDL-LARSIGMVEVNTVDKYQGRDKSIVLVSFVRSNKDGTVGELLK-DWR------- 1028

  Fly  1111 CSKRLNVAVSRARAMMIIFG 1130
               |||||::||:..:|:.|
Human  1029 ---RLNVAITRAKHKLILLG 1045

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
armi	NP_647816.2	DEXXQc_Mov10L1	697..949	CDD:350836	59/252 (23%)
		DNA2	<829..1148	CDD:440729	85/337 (25%)
DNA2	XP_006717743.1	DNA2_N-like	156..395	CDD:411722	60/362 (17%)
		TIGR00376	501..1062	CDD:273041	152/644 (24%)
		DEXXQc_DNA2	655..858	CDD:350799	59/252 (23%)