DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment armi and Mov10

DIOPT Version :9

Sequence 1:	NP_001014556.1	Gene:	armi / 38427	FlyBaseID:	FBgn0041164	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	NP_001156912.1	Gene:	Mov10 / 17454	MGIID:	97054	Length:	1077	Species:	Mus musculus

Alignment Length:	1128	Identity:	327/1128 - (28%)
Similarity:	490/1128 - (43%)	Gaps:	276/1128 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 GCVVEYLTFTTGEAMRVVKVKSILEHSWEDTSQKEIEKAVDNLKNEKP-TFFNTETRSVLGLISQ 177
            |..:..|.|.|...:|..|:     ..|.|....|..:.       || :..:.:.||:|..|..
Mouse   133 GMKIANLAFVTKTRVRFFKL-----DRWADVQLPEKRRI-------KPGSNISKQHRSLLARIFH 185

  Fly   178 RLAS------SIDVETE------YGQLTVELDNIEMNFIPTNGDRVRLECNIQLDDGFVDKQGEI 230
            ..|.      .:|||.:      .|||.:.||        .|...|   ..::|.:|    ..:.
Mouse   186 DRAEYLHGKHGVDVEVQGPHEARDGQLLIHLD--------LNRKEV---LTLRLRNG----GSKP 235

  Fly   231 LEVTKLFPTRIQEGEKCIVER-VYVH-----MVVLGP-ETYILKTDLPTGTDLHLGDIVLADLIE 288
            :.:|.|||.       |...: |:.|     ...||| |:|          :||:
Mouse   236 VTLTHLFPL-------CWTPQFVFYHGEQDLPCPLGPGESY----------ELHI---------- 273

  Fly   289 CQYSKFTRRAIKITPLEKNFGATKLTQQSSMGSSGSGKAVTVTGVNRFITAELWQKESVSLKLTN 353
              |.|        |.:...|.||.|.:....|.||:..|.|.. :.||:.|......:..||.|.
Mouse   274 --YCK--------TSIVGYFPATVLWELLGPGESGAEGAETFY-IARFLAAVAHSPLAAQLKPTT 327

  Fly   354 NLNRTLRLESITVCNDSESQLSVVSPLESKEISSGSEITVTFEIHTQFLGEAIEKYVLNFDLLKV 418
            ...|..||...:|..:.      :...|..:.:.|.|:.::..:.|.:....:
Mouse   328 PFKRPPRLTRNSVLTNR------IEEGERPDRAKGYELELSLALGTYYPPILL------------ 374

  Fly   419 RRVFTVIVCKTKEEVAEAEKRMIAAEALMAPGRNSQERSRFYANQVWCNKVDVIPGQQIVTKRRF 483
                                |.:....|..|
Mouse   375 --------------------RQLLPTLLQGP---------------------------------- 385

  Fly   484 VALRLGCFEVPKELRQICLTSERRQEMIKAIEQHYSFLTEPLSIKTYMHRFRLLLHLEEIECFVN 548
                 ..|..|||:.:           |||      .|...|..:.|..:.||||||||::...:
Mouse   386 -----SIFTAPKEVAE-----------IKA------QLETTLKSRNYEVKLRLLLHLEELQMEHD 428

  Fly   549 FRNYDRDRAHFLRD-----GEFLTLQIENLAERRPSLVIGDTL-RVINPWSDPDSQTTKSYEGII 607
            .|:||.|......|     ...|||::..:||.|||::.||.| .:::..:..|...|  |:|.:
Mouse   429 IRHYDLDSVPMTWDPVDQNPRLLTLEVPGVAESRPSVLRGDHLFALLSSETQQDDPVT--YKGFV 491

  Fly   608 HKVLFDRILLKFHSSFQEKY-NGEDYRLEFYFSRYSFRKQHHAISKIVGVMGEDFLFPS--KVTK 669
            |||..||:.|.|.:|...:: :|..:::.|.|:|...|.||.|:.    :.|...|:|.  .|..
Mouse   492 HKVELDRVKLSFSTSLLSRFVDGLTFKVNFTFNRQPLRVQHRALE----LTGRWVLWPMLFPVAS 552

  Fly   670 RENPQL--DVYMKDDDMYLYDSKLEWYNQSLNSIQKRAVFNILRGEAENIPYVLFGPPGSGKTMT 732
            |....|  ||..|     |||..||     .|..|.:|:.:|:||.....||::|||||:|||:|
Mouse   553 RGVSLLPSDVKFK-----LYDRSLE-----SNPEQLQAMKHIVRGTTRPAPYIIFGPPGTGKTVT 607

  Fly   733 LIETLLQLVRNLPGARILVGTPSNSSADLVTKRLIDSKALLQGDFIRLVSYNQVEKDL-IPPEIM 796
            |:|.:.|:|::||.|.||...||||.|||:.:||   :..|.....||::   ..:|: :.||.:
Mouse   608 LVEAIKQVVKHLPKAHILACAPSNSGADLLCQRL---RVHLPSSIYRLLA---PSRDIRMVPEDI 666

  Fly   797 SYCATSDVGAVGSCEDKMMVTESGLKLRCQAKFIGTHRITISTCTTLGNFLQLGFPAGHFTHVLF 861
            ..|...|             .:.|..:....|.:..:|:.|:|..|....:...||..||||:..
Mouse   667 KTCCNWD-------------AKKGEYVYPAKKHLQQYRVLITTLITASRLVSAQFPIDHFTHIFI 718

  Fly   862 DEAGQCTEPETMVPIVMLTKKR------SQVVLSGDPRQLQSIVTSRIASKMGFSISFLERLLE- 919
            ||||.|.|||::|.|..|...:      .|:||:||||||..::.|.:|.|.|...|.|||||.
Mouse   719 DEAGHCMEPESLVAIAGLMDVKETGNPGGQLVLAGDPRQLGPVLRSPLALKHGLGYSLLERLLAY 783

  Fly   920 RSPYRKDLQRFPESSGYNPLVLTKLLYNYRALPSIMSIYSRLFYDDELIPVLSEKDSRESRLLSK 984
            .|.|:|.      .:||:|..:||||.|||:.|:|:.|.::|:||.||.......|....
Mouse   784 NSLYKKG------PNGYDPQFITKLLRNYRSHPTILDIPNQLYYDGELQACADVVDRERF----- 837

  Fly   985 LRCVFESEKDIP-QAHGTFFYGIIGENRQNNDSPSWFNPQEVREVFLMTIALY------------ 1036
              |.:|.   :| |.....|:|::|::.:..:|||:|||:|.     .|:..|
Mouse   838 --CRWEG---LPQQGFPIIFHGVMGKDEREGNSPSFFNPEEA-----ATVTSYLKQLLAPSSKKG 892

  Fly  1037 RANVTADQIGIITPYQKQVKMLRSMFI-------GTDVVMP-KIGSVEEFQGQERDIILISTVRS 1093
            :|.::...:|:|:||:|||:.:|....       |.|.:.. |:|||||||||||.:||||||||
Mouse   893 KARLSPRNVGVISPYRKQVEKIRYCITKLDRELRGLDDIKDLKVGSVEEFQGQERSVILISTVRS 957

  Fly  1094 SEEILRMDARFSLGFVRCSKRLNVAVSRARAMMIIFGNPHLLAVDECWRQLILFCVKNNAYFGCD 1158
            |:..:::|..|:|||::..||.||||:||:|::|:.|||.||..|..|:..:.||.:|..|.||.
Mouse   958 SQSFVQLDLDFNLGFLKNPKRFNVAVTRAKALLIVVGNPLLLGHDPDWKTFLEFCKENGGYTGCP 1022

  Fly  1159 LP-QMVINQKDEVPVCLETFVPS 1180
            .| ::.:.|..::...|....||
Mouse  1023 FPAKLDLQQGQDLLQGLSKLSPS 1045

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
armi	NP_001014556.1	AAA_11	698..902	CDD:289831	75/210 (36%)
		AAA_19	720..768	CDD:289986	27/47 (57%)
		DNA2	<840..1155	CDD:224037	132/342 (39%)
		UvrD_C_2	909..1132	CDD:304668	92/244 (38%)
Mov10	NP_001156912.1	AAA_11	574..765	CDD:289831	75/209 (36%)
		P-loop_NTPase	574..>761	CDD:304359	75/205 (37%)
		AAA_12	772..996	CDD:289832	92/244 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	143	1.000	Domainoid score	I4634
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4684
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148890at33208
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	1	1.000	-	-		otm44066
orthoMCL	1	0.900	-	-		OOG6_101029
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9180
SonicParanoid	1	1.000	-	-		X1732
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.700